National Biocontainment Laboratories (NBLs) Operations Support

国家生物防护实验室 (NBL) 运营支持

• 批准号: 8125477
• 负责人: JAMES W. LEDUC
• 金额: $ 1157.7万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-31 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125477
• 关键词: National; Biocontainment; Laboratories; NBLs; Operations

DESCRIPTION (provided by applicant): The mission of the Galveston National Laboratory (GNL) is to conduct basic and applied research designed to improve the prevention, diagnosis and treatment of naturally emerging and purposefully disseminated infectious diseases. The GNL provides BSL4, BSL3 and BSL2 laboratories designed to allow the safe conduct of this work. Our strategic plan is to develop a portfolio of basic research and translational product development activities that will fully occupy the GNL containment spaces, including implementation of strategies for cost recovery for each of our Integrated Service Support Divisions; however, we realize that the exceptional costs of security, utilities and maintenance required for the safe and secure operations will continue to demand supplemental support. The GNL was dedicated on November 11, 2008. As of June, 2010, the entire GNL has been inspected by the CDC and USDA Select Agent Programs and approved for full operations. GNL BSL2 and ABSL3 laboratories are active and moving toward full occupancy; the in vitro BSL3 and BSL3E labs are operational with non-Select Agents, and we will soon begin Select Agent use. We anticipate beginning operations in the BSL4 laboratories in August 2010, initially conducting research on pathogens requiring lower containment and handling BSL4 pathogens by the end of 2010. Plans for routine, emergency and preventive laboratory maintenance are operational, as are weather emergency plans and plans for external evaluation of programs. The GNL is organized around 6 Cores and 7 service divisions (Administration, Facilities Maintenance and Operations, Biosecurity, Environmental Health and Biosafety Regulations and Requirements, Regulatory Compliance, and Integrated Support Services Cores; Aerobiology, Preclinical, Assay Development, Pathology, Insectary, Imaging and Immunology service divisions). Staff training is underway, facilitated by the National Biocontainment Training Center. Two active community advisory groups help to maintain a robust and positive dialogue with local community leaders. The GNL assisted the Texas Department of State Health in response to the 2009 H1N1 epidemic and is building upon that model to formalize state and national emergency response activities.

描述（由申请人提供）： 加尔维斯顿国家实验室（GNL）的使命是开展基础和应用研究，旨在改善自然出现和有目的传播的传染病的预防、诊断和治疗。GNL提供了BSL 4、BSL 3和BSL 2实验室，旨在确保这项工作的安全进行。我们的战略计划是开发一系列基础研究和转化产品开发活动，这些活动将完全占据GNL的封闭空间，包括为我们的每个综合服务支持部门实施成本回收战略;但是，我们认识到，安全和安全运营所需的安保、公用事业和维护的特殊成本将继续需要补充支持。GNL于2008年11月11日投入使用。截至2010年6月，整个GNL已通过CDC和USDA选择代理程序的检查，并批准全面运营。GNL BSL 2和ABSL 3实验室正在积极开展工作，并正朝着满员的方向发展;体外BSL 3和BSL 3E实验室正在使用非选择性药物，我们将很快开始使用选择性药物。我们预计BSL 4实验室将于2010年8月开始运作，最初对需要较低防护的病原体进行研究，并在2010年底前处理BSL 4病原体。常规、紧急和预防性实验室维护计划以及天气应急计划和方案外部评估计划都已投入运行。GNL由6个核心和7个服务部门组成（行政、设施维护和运营、生物安保、环境卫生和生物安全法规和要求、法规合规性和综合支持服务核心;航空生物学、临床前、检测开发、病理学、昆虫学、成像和免疫学服务部门）。在国家生物防护培训中心的协助下，正在进行工作人员培训。两个活跃的社区咨询小组帮助与当地社区领导人保持积极的对话。GNL协助得克萨斯州卫生部应对2009年H1N1流感疫情，并正在该模式的基础上，正式确定州和国家的应急活动。