Regional Biocontainment Laboratories Facility and Building System Upgrades Support

项目概要/摘要： 杜克地区生物防护实验室（RBL）是在美国国家研究院的资助下建造的 美国国立卫生研究院（NIH）支持必要的基础研究，以开发药物，诊断和疫苗， 新出现/再出现的感染和生物防御。最先进的生物防护设施， 支持实验室和小动物研究，完全委托并于2007年在杜克上开放运行 位于北卡罗来纳州达勒姆的大学医学院校园。杜克RBL设施支持赠款/合同资助的 研究人员，并提供生物防护实验室，创新的主机监测分析和小动物模型 在成本回收的基础上通过核心服务中心单位。十四年的使用和时间已经呈现 一些杜克RBL设施、系统和关键核心研究设备过时，或需要维修， 更新或现代化。我们已经确定了该设施现有物理设施的六个关键缺陷， 限制生物安全、安保或威胁其提供的服务和研究相关服务的基础设施 它支持的活动。我们将在三个具体目标中解决这些不足之处：1）现代化建筑空气 控制系统-更新陈旧的BSL 3/ABSL 3建筑控制系统、压力监测器和软件。 重新平衡、测试、验证和重新认证所有受影响的BSL 3/ABSL 3空间; 2）实现生物安全和安保现代化 系统-更换BSL 2/BSL 3/ABSL 3实验室中老化/损坏的生物安全柜。修复和升级 BSL 3化学污水处理系统的组成部分。更换损坏或陈旧的闭路 安全摄像头、布线以及与建筑物安全控制系统的集成;以及3）现代化研究 资源-更换BSL 3细胞中过时的高密闭细胞分选器和定制的Bioprotect罩 分类核心设施。升级Allentown生物防护小鼠笼架上的鼓风机控制模块 在ABSL 3。这些宗旨/目标将由高度整合的项目管理团队完成， 坚实的机构支持和值得信赖的承包商/供应商，它们是原始设计和施工的一部分 （二）对被保险人的人身安全和财产安全造成的损害; 过去14年。

Project Summary/Abstract: The Duke Regional Biocontainment Laboratory (RBL) was constructed with funding from the National Institutes of Health (NIH) to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. The state-of-the-art biocontainment facility, designed to support lab and small animal research, was fully commissioned and opened for operation in 2007 on the Duke University Medical School Campus in Durham, NC. The Duke RBL facility supports grant/contract-funded investigators and also provides biocontainment labs, innovative host monitoring assays and small animal models through Core Service Center Units on a cost recovery basis. Fourteen years of use and time have rendered some of the Duke RBL facilities, systems and critical core research equipment obsolete, or in need of repair, replacement or modernization. We have identified six critical deficiencies of the facility’s existing physical infrastructure that limit biosafety, security or threaten the provision of services it offers and research-related activities it supports. We will address these deficiencies in our three Specific Aims: 1) Modernize Building Air Control Systems – Upgrade obsolete BSL3/ABSL3 building controls systems, pressure monitors and software. Rebalance, test, validate and re-certify all impacted BSL3/ABSL3 space; 2) Modernize Biosafety and Security Systems - Replace aged/damaged biosafety cabinets in BSL2/BSL3/ABSL3 laboratories. Repair and upgrade components of the BSL3 chemical effluent treatment system. Replace damaged or obsolete closed circuit security cameras, cabling and integration with building security control systems; and 3) Modernize Research Resources – Replace the obsolete high-containment cell sorter and custom Bioprotect hood in the BSL3 Cell Sorting Core facility. Upgrade the blower control modules on the Allentown Biocontainment mouse cage racks in the ABSL3. These Aims/Goals will be accomplished by a highly integrated project management team with solid institutional support and trusted contractors/vendors that were part of the original design and construction of the facility and/or have been part of the continuous maintenance, repair and certification of the facility for the past 14 years.