Regional Biocontainment Laboratories Facility and Building System Upgrades Support

项目摘要/摘要： 杜克地区生物遏制实验室(RBL)是由国家研究所提供资金建造的 卫生部(NIH)支持必要的基础研究，以开发药物、诊断和疫苗 新出现/再次出现的感染和生物防御。最先进的生物遏制设施，旨在 支持实验室和小动物研究，于2007年在杜克完全委托并开放运营 北卡罗来纳州达勒姆的大学医学院校区。杜克大学RBL基金支持赠款/合同资助 研究人员还提供生物遏制实验室、创新的宿主监测分析和小动物模型 在收回成本的基础上通过核心服务中心单位。十四年的使用和时间使 杜克大学RBL的一些设施、系统和关键核心研究设备陈旧或需要维修， 更替或现代化。我们已经确定了该设施现有体检的六个严重缺陷 限制生物安全、安保或威胁其提供的服务和与研究相关的服务的基础设施 它所支持的活动。我们将在我们的三个具体目标中解决这些不足：1)使建筑空气现代化 控制系统-升级过时的BSL3/ABSL3建筑控制系统、压力监测器和软件。 重新平衡、测试、验证和重新认证所有受影响的BSL3/ABSL3空间；2)使生物安全和安保现代化 系统-更换BSL2/BSL3/ABSL3实验室中老化/损坏的生物安全柜。维修和升级 BSL3化学废水处理系统的组件。更换损坏或陈旧的闭合电路 安全摄像头、布线以及与建筑物安全控制系统的集成；以及3)现代化研究 资源-更换BSL3细胞中过时的高含物细胞分类器和定制的BioProtect头罩 分拣核心设施。升级Allentown生物隔离鼠笼机架上的鼓风机控制模块 在ABSL3中。这些目标将由一个高度集成的项目管理团队来实现，该团队具有 坚实的机构支持和值得信赖的承包商/供应商是原始设计和施工的一部分 和/或已成为设施的持续维护、维修和认证的一部分 过去的14年里。

Project Summary/Abstract: The Duke Regional Biocontainment Laboratory (RBL) was constructed with funding from the National Institutes of Health (NIH) to support basic research necessary to develop drugs, diagnostics, and vaccines for emerging/reemerging infections and biodefense. The state-of-the-art biocontainment facility, designed to support lab and small animal research, was fully commissioned and opened for operation in 2007 on the Duke University Medical School Campus in Durham, NC. The Duke RBL facility supports grant/contract-funded investigators and also provides biocontainment labs, innovative host monitoring assays and small animal models through Core Service Center Units on a cost recovery basis. Fourteen years of use and time have rendered some of the Duke RBL facilities, systems and critical core research equipment obsolete, or in need of repair, replacement or modernization. We have identified six critical deficiencies of the facility’s existing physical infrastructure that limit biosafety, security or threaten the provision of services it offers and research-related activities it supports. We will address these deficiencies in our three Specific Aims: 1) Modernize Building Air Control Systems – Upgrade obsolete BSL3/ABSL3 building controls systems, pressure monitors and software. Rebalance, test, validate and re-certify all impacted BSL3/ABSL3 space; 2) Modernize Biosafety and Security Systems - Replace aged/damaged biosafety cabinets in BSL2/BSL3/ABSL3 laboratories. Repair and upgrade components of the BSL3 chemical effluent treatment system. Replace damaged or obsolete closed circuit security cameras, cabling and integration with building security control systems; and 3) Modernize Research Resources – Replace the obsolete high-containment cell sorter and custom Bioprotect hood in the BSL3 Cell Sorting Core facility. Upgrade the blower control modules on the Allentown Biocontainment mouse cage racks in the ABSL3. These Aims/Goals will be accomplished by a highly integrated project management team with solid institutional support and trusted contractors/vendors that were part of the original design and construction of the facility and/or have been part of the continuous maintenance, repair and certification of the facility for the past 14 years.