National Biocontainment Laboratories (NBLs) Operations Support

国家生物防护实验室 (NBL) 运营支持

• 批准号: 8496688
• 负责人: JAMES W. LEDUC
• 金额: $ 1350万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-31 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496688
• 关键词: Applied Research; Basic Science; Bioterrorism; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Communities; Containment; Diagnosis; Diagnostic tests; Emergency Situation; Emerging Communicable Diseases; Environmental Health; Epidemic; Health; Image; Immunology; In Vitro; Influenza A Virus, H1N1 Subtype; Instruction; Laboratories; Maintenance; Mission; Modeling; Pathology; Prevention; Preventive; Program Evaluation; Recovery; Regulation; Research; Scientist; Secure; Security; Services; Strategic Planning; Texas; Training; Vaccines; Weather; Work; assay development; biosecurity; cost; design; effective therapy; improved; operation; pathogen; pre-clinical; prevent; product development; programs; response

The mission ofthe Galveston National Laboratory (GNL) is to conduct basic and applied research designed to improve the prevention, diagnosis and treatment of naturally emerging and purposefully disseminated infectious diseases. The GNL provides BSL4, BSL3 and BSL2 laboratories designed to allow the safe conduct of this work. Our strategic plan is to develop a portfolio of basic research and transiational product development activities that will fully occupy the GNL containment spaces, including implementation of strategies for cost recovery for each of our Integrated Service Support Divisions; however, we realize that the exceptional costs of security, utilities and maintenance required for the safe and secure operations will confinue to demand supplemental support. The GNL was dedicated on November 11, 2008. As of June, 2010, the entire GNL has been inspected by the CDC and USDA Select Agent Programs and approved for full operations. GNL BSL2 and ABSL3 laboratories are active and moving toward full occupancy; the in vitro BSL3 and BSL3E labs are operational with non-Select Agents, and we will soon begin Select Agent use. We anticipate beginning operations in the BSL4 laboratories in August 2010, initially conducting research on pathogens requiring lower containment and handling BSL4 pathogens by the end of 2010. Plans for routine, emergency and preventive laboratory maintenance are operational, as are weather emergency plans and plans for external evaluation of programs. The GNL is organized around 6 Cores and 7 service divisions (Administration, Facilities Maintenance and Operations, Biosecurity, Environmental Health and Biosafety Regulations and Requirements, Regulatory Compliance, and Integrated Support Services Cores; Aerobiology, Preclinical, Assay Development, Pathology, Insectary, Imaging and Immunology service divisions). Staff training is undenway, facilitated by the National Biocontainment Training Center. Two active community advisory groups help to maintain a robust and positive dialogue with local community leaders. The GNL assisted the Texas Department of State Health in response to the 2009 H1N1 epidemic and is building upon that model to formalize state and national emergency response activities.

加尔维斯顿国家实验室（GNL）的使命是进行基础和应用研究，旨在 改善自然出现和有目的地传播的疾病的预防、诊断和治疗 传染病。 GNL 提供 BSL4、BSL3 和 BSL2 实验室，旨在允许安全 这项工作的开展。我们的战略计划是开发一系列基础研究和过渡产品 将完全占据 GNL 收容空间的开发活动，包括实施 我们每个综合服务支持部门的成本回收策略；然而，我们意识到 安全可靠的运营所需的安保、公用事业和维护的额外费用将 继续要求补充支持。 GNL 于 2008 年 11 月 11 日落成。截至 6 月， 2010年，整个GNL已通过CDC和USDA精选代理计划的检查并获得批准 全面运营。 GNL BSL2 和 ABSL3 实验室正在积极运作，并正朝着全面入住的方向发展；体外的 BSL3 和 BSL3E 实验室可与非 Select Agent 一起使用，我们很快就会开始使用 Select Agent。我们 预计 BSL4 实验室将于 2010 年 8 月开始运行，最初进行以下研究 到 2010 年底，需要较低遏制和处理 BSL4 病原体的病原体。常规计划， 应急和预防性实验室维护已投入运行，天气应急计划和 计划的外部评估。 GNL 由 6 个核心和 7 个服务部门组成 （管理、设施维护和运营、生物安全、环境健康和生物安全 法规和要求、监管合规性和综合支持服务核心； 空气生物学、临床前、检测开发、病理学、昆虫学、成像和免疫学服务 部门）。在国家生物防护培训中心的推动下，员工培训正在进行中。两个活跃 社区咨询小组帮助与当地社区领导人保持强有力和积极的对话。 GNL 协助德克萨斯州卫生部应对 2009 年 H1N1 流感疫情，并正在 在此模式的基础上，将州和国家应急活动正式化。