National Biocontainment Laboratories (NBLs) Operations Support

国家生物防护实验室 (NBL) 运营支持

• 批准号: 8269879
• 负责人: JAMES W. LEDUC
• 金额: $ 1410万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-31 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8269879
• 关键词: Applied Research; Basic Science; Bioterrorism; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Communities; Containment; Diagnosis; Diagnostic tests; Emergency Situation; Emerging Communicable Diseases; Environmental Health; Epidemic; Health; Image; Immunology; In Vitro; Influenza A Virus, H1N1 Subtype; Instruction; Laboratories; Maintenance; Mission; Modeling; Pathology; Prevention; Preventive; Program Evaluation; Recovery; Regulation; Research; Scientist; Secure; Security; Services; Strategic Planning; Texas; Training; Vaccines; Weather; Work; assay development; biosecurity; cost; design; effective therapy; improved; operation; pathogen; pre-clinical; prevent; product development; programs; response

The mission ofthe Galveston National Laboratory (GNL) is to conduct basic and applied research designed to improve the prevention, diagnosis and treatment of naturally emerging and purposefully disseminated infectious diseases. The GNL provides BSL4, BSL3 and BSL2 laboratories designed to allow the safe conduct of this work. Our strategic plan is to develop a portfolio of basic research and transiational product development activities that will fully occupy the GNL containment spaces, including implementation of strategies for cost recovery for each of our Integrated Service Support Divisions; however, we realize that the exceptional costs of security, utilities and maintenance required for the safe and secure operations will confinue to demand supplemental support. The GNL was dedicated on November 11, 2008. As of June, 2010, the entire GNL has been inspected by the CDC and USDA Select Agent Programs and approved for full operations. GNL BSL2 and ABSL3 laboratories are active and moving toward full occupancy; the in vitro BSL3 and BSL3E labs are operational with non-Select Agents, and we will soon begin Select Agent use. We anticipate beginning operations in the BSL4 laboratories in August 2010, initially conducting research on pathogens requiring lower containment and handling BSL4 pathogens by the end of 2010. Plans for routine, emergency and preventive laboratory maintenance are operational, as are weather emergency plans and plans for external evaluation of programs. The GNL is organized around 6 Cores and 7 service divisions (Administration, Facilities Maintenance and Operations, Biosecurity, Environmental Health and Biosafety Regulations and Requirements, Regulatory Compliance, and Integrated Support Services Cores; Aerobiology, Preclinical, Assay Development, Pathology, Insectary, Imaging and Immunology service divisions). Staff training is undenway, facilitated by the National Biocontainment Training Center. Two active community advisory groups help to maintain a robust and positive dialogue with local community leaders. The GNL assisted the Texas Department of State Health in response to the 2009 H1N1 epidemic and is building upon that model to formalize state and national emergency response activities.

加尔维斯顿国家实验室(GNL)的任务是进行基础和应用研究 改进自然出现和故意传播的疾病的预防、诊断和治疗 传染病。GNL提供BSL4、BSL3和BSL2实验室，旨在允许安全 这项工作的进行。我们的战略计划是开发一系列基础研究和过渡产品 将完全占据GNL安全壳空间的开发活动，包括实施 我们每个综合服务支持部门的成本回收战略；然而，我们意识到 安全和有保障的运作所需的安保、水电费和维护费的额外费用将 仅限于要求补充支持。GNL于2008年11月11日投入使用。截至6月， 2010年，整个GNL已经通过CDC和USDA选择代理计划的检查，并批准用于 全面运作。GNL BSL2和ABSL3实验室正在积极进行，并朝着满员的方向发展；体外 BSL3和BSL3E实验室可用于非选择代理，我们将很快开始使用选择代理。我们 预计于2010年8月在BSL4实验室开始运作，初步开展研究 需要较低遏制的病原体，并在2010年底之前处理BSL4病原体。例行公事， 应急和预防性实验室维护正在运行，天气应急计划和 项目的外部评估计划。GNL由6个核心和7个服务部门组成 (行政、设施维护和运营、生物安全、环境健康和生物安全 法规和要求、法规遵从性和综合支助服务核心； 空气生物学、临床前、化验发展、病理学、昆虫学、影像和免疫学服务 分部)。工作人员培训正在进行中，由国家生物遏制培训中心提供便利。两个活跃的 社区咨询小组帮助与当地社区领导人保持强有力和积极的对话。 GNL协助德克萨斯州卫生部应对2009年H1N1疫情，目前 在这一模式的基础上，将州和国家的应急活动正规化。