The VALIDATE study

验证研究

• 批准号: 8335795
• 负责人: Luigi Ferrucci
• 金额: $ 10.68万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8335795
• 关键词: Age; Aging; Atherosclerosis; Blood Vessels; Calcium; Clinical; Coronary; Coronary Arteriosclerosis; Coronary artery; Coronary heart disease; Data; Development; Disease; Event; Female; Functional disorder; Gender; Goals; Incidence; Individual; Institution; Intervention; Measures; Medical; National Institute on Aging; Observational Study; Participant; Pathologic; Prevalence; Recruitment Activity; Risk Factors; Schedule; Severities; Structure; Testing; adverse outcome; disease diagnosis; male; normal aging; premature; programs; trend; volunteer

This is a longitudinal, observational study, which does not include any intervention. There are three study groups. The first group consists of BLSA participants without known coronary disease; the second consists of individuals with a coronary artery calcium score less than the 25th percentile for their age and gender; the third group consists of individuals with premature coronary artery disease (diagnosis made at age <60 in females and <50 in males) or with a coronary calcium score which is greater than the 50th percentile for their age and gender. Participants in the second and third group listed above are recruited from the Johns Hopkins Medical Institutions. Recruitment into these groups has been on or ahead of schedule, and we are ready to begin the longitudinal component of the study. Recruitment into the first group is performed at the National Institute on Aging. The past year saw a marked improvement in our ability to recruit these volunteers, and we hope to continue this trend. To reach our goal, we have set a target of approximately 10 BLSA participants per month.

这是一项纵向观察性研究，不包括任何干预措施。有三个学习小组。第一组由没有已知冠状动脉疾病的BLSA参与者组成；第二组由冠状动脉钙评分低于其年龄和性别的第25百分位数的个体组成；第三组包括患有过早冠状动脉疾病的个体（女性小于60岁，男性小于50岁）或冠状动脉钙评分高于其年龄和性别的第50百分位数。