NIA IRP Comparative Medicine Section

NIA IRP 比较医学部分

• 批准号: 9550723
• 负责人: Luigi Ferrucci
• 金额: $ 726.68万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9550723
• 关键词: Accreditation; Advisory Committees; Age; Aging; Animal Care and Use Committees; Animal Experimentation; Animal Welfare; Animals; Area; Behavior; Behavioral Research; Biology of Aging; Biomedical Research; Breeding; Caring; Contractor; Contracts; Educational process of instructing; Ensure; Facility Accesses; Genotype; Guidelines; Health; Housing; International; Investigation; Laboratory Animals; Measures; Medicine; Mission; Mus; Outcome; Performance; Phenotype; Privatization; Procedures; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Services; Site Visit; Suggestion; Techniques; Testing; Training; United States National Institutes of Health; Update; Work; animal care; biosecurity; comparative; improved; meetings; member; novel; programs; sample collection

The Comparative Medicine Section (CMS) of the NIA is responsible for the well-being of research animals employed in the investigation of pertinent questions about the biology of aging. CMS responsibilities include, but are not limited to, the provision of housing and care that meets species-specific and age-specific needs and requirements. The CMS also aims to support NIA scientific research by providing training to investigators in the humane handling of these animals and the performance of experimental techniques. Furthermore, the CMS ensures that all animal research is conducted in compliance with NIA, NIH, and federal regulations and guidelines. The CMS works to establish firm, consistent resource management while maintaining a collaborative relationship with investigators. Technical assistance in the form of breeding management, sample collection, and experimental manipulations is available upon request. The CMS also provides mouse behavior phenotyping services to NIA investigators and holds a contract used by investigators to genotype their animals. Approximately 2700 samples/month are sent to the contractor. For investigators wishing to access the NIA vivarium, facility training must be completed prior to initial entry. CMS provided training includes facility access requirements, biosecurity measures, proper animal handling, relevant regulations, and other related issues. Updates in regulations or facility procedures are provided by the Animal Program Director (APD) at bimonthly Advisory Committee to the Animal Program (ACAP) meetings. The animal program, vivarium, and animal laboratory areas are inspected and evaluated twice a year by the NIA Animal Care and Use Committee (ACUC). These semi-annual reviews are conducted in accordance with federal regulations. In addition to these internal reviews, the animal program is assessed every three years by AAALAC (formerly the Association for the Assessment and Accreditation of Laboratory Animal Care, International), a private organization that promotes the humane treatment of animals in science. In June 2016 the NIA animal program was site visited by AAALAC. The outcome of the site visit was full continuing accreditation with no suggestions for improvement. CMS staff members assist with NIA IRP research projects and may conduct novel research with a focus on improving the health and welfare of animals in their care. CMS initiated projects aim to answer current questions in facility management and in the special needs and care of aging animals.

NIA的比较医学科（CMS）负责研究衰老生物学相关问题的研究动物的福祉。 CMS的责任包括但不限于提供住房和照顾，以满足特定物种和特定年龄的需求和要求。 CMS还旨在通过向研究人员提供人道处理这些动物和实验技术性能的培训来支持NIA的科学研究。 此外，CMS确保所有动物研究的进行符合NIA、NIH和联邦法规和指南。 CMS致力于建立公司，一致的资源管理，同时保持与调查人员的合作关系。 如有要求，可提供育种管理、样品收集和实验操作等形式的技术援助。 CMS还为NIA研究人员提供小鼠行为表型分析服务，并与研究人员签订合同，对动物进行基因分型。 每月向承包商发送约2700个样品。 对于希望进入NIA动物园的研究者，必须在首次进入之前完成设施培训。 CMS提供的培训包括设施准入要求、生物安全措施、适当的动物处理、相关法规和其他相关问题。 动物项目总监（APD）在每两个月一次的动物项目咨询委员会（ACAP）会议上提供法规或机构程序的更新。 NIA动物护理和使用委员会（ACUC）每年对动物项目、动物饲养场和动物实验室区域进行两次检查和评估。 这些半年度审查按照联邦法规进行。 除了这些内部审查外，动物项目每三年由AAALAC（前身为国际实验室动物评估和认可协会）进行评估，AAALAC是一个促进科学中人道对待动物的私人组织。 2016年6月，AAALAC对NIA动物项目进行了实地考察。实地访问的结果是完全继续认证，没有提出改进建议。 CMS的工作人员协助NIA IRP研究项目，并可能进行新的研究，重点是改善他们照顾的动物的健康和福利。 CMS发起的项目旨在回答设施管理和老龄动物特殊需求和护理方面的当前问题。