Functional neuroimaging of language processing in primary progressive aphasia

原发性进行性失语症语言处理的功能神经影像学

• 批准号: 8203671
• 负责人: Stephen M Wilson
• 金额: $ 11.56万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-07 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8203671
• 关键词: Functional; neuroimaging; language; processing; primary

DESCRIPTION (provided by applicant): Primary progressive aphasia (PPA) is a clinical syndrome in which degeneration of language regions in the dominant hemisphere is associated with progressive deficits in speech and/or language function. The overall goals of this project are to use functional magnetic resonance imaging (fMRI) to investigate neural changes underlying linguistic deficits in PPA, and to use this information to better discriminate patients with variants of PPA from each other and from normal aging. Recent studies have identified three clinical variants of PPA: progressive non-fluent aphasia (PNFA), semantic dementia (SD) and logopenic progressive aphasia (LPA). Each variant is associated with characteristic linguistic features, distinct patterns of brain atrophy, and different likelihoods of particular underlying pathogenic processes, making correct differential diagnosis highly relevant. We will recruit 48 patients with PPA (16 of each variant) and 24 normal controls over a three year period, and acquire fMRI data along with structural MRI, linguistic and cognitive measures. The fMRI paradigm consists of a syntactic processing task with seven conditions parametrically varying in syntactic complexity. The research will address two specific aims. The first is to identify the relationships between volume loss, changes in functional MRI activation, and linguistic deficits, in the different PPA variants. The second aim is to improve differential diagnosis of PPA variants using machine learning algorithms incorporating both structural and functional imaging measures. PUBLIC HEALTH RELEVANCE: PPA is a devastating disorder that prevents individuals from communicating and functioning in society. The knowledge gained in this study will increase our understanding of the neural basis of language processing and its breakdown in PPA, and will contribute to earlier, more accurate differential diagnosis of PPA variants, enabling emerging therapies to be targeted to likely underlying etiologies.

描述（由申请人提供）：主要进行性失语症（PPA）是一种临床综合征，其中主要半球语言区域的退化与语音和/或语言功能的渐进性缺陷有关。该项目的总体目标是使用功能性磁共振成像（fMRI）来研究PPA语言缺陷的神经变化，并使用此信息来更好地区分彼此和正常衰老的变体患者。最近的研究已经确定了PPA的三种临床变异：进行性非浮力失语（PNFA），语义痴呆（SD）和徽标进行性渐进失语（LPA）。每个变体都与特征语言特征，脑萎缩的不同模式以及特定潜在的致病过程的不同可能性有关，从而使正确的鉴别诊断高度相关。我们将在三年内招募48例PPA患者（每种变体中的16例）和24个正常对照，并获取fMRI数据以及结构MRI，语言和认知措施。 fMRI范式由句法处理任务组成，七个条件的参数构成句法复杂性有所不同。该研究将解决两个具体目标。首先是在不同的PPA变体中确定体积丢失，功能性MRI激活变化和语言缺陷之间的关系。第二个目的是使用结合结构和功能成像指标的机器学习算法来改善PPA变体的差异诊断。 公共卫生相关性：PPA是一种毁灭性疾病，可防止个人在社会中沟通和运作。这项研究中获得的知识将增加我们对语言处理的神经基础及其对PPA的细分的理解，并将有助于更早，更准确的PPA变体差异诊断，从而使新兴疗法成为可能潜在的病因。