Automated Interactive Text Messaging to Assess Adolescent Depression

自动交互式短信评估青少年抑郁症

• 批准号: 8057441
• 负责人: GRAHAM J. EMSLIE
• 金额: $ 14.69万
• 依托单位: CENTER FOR PSYCHOLOGICAL CONSULTATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8057441
• 关键词: 17 year old; Adolescent; Adopted; Adult; Aftercare; Age; Antidepressive Agents; Attention; Automation; Behavior; Behavioral; Cellular Phone; Child; Childhood; Clinical; Clinical Trials; Communication; Computers; Data; Databases; Depressed mood; Development; Diagnosis; Disease; Environment; Feedback; Feeling suicidal; Fluoxetine; Frequencies; Future; Health; Individual; Interactive Communication; Internet; Intervention; Life; Major Depressive Disorder; Measures; Mental Depression; Mental Health; Methods; Monitor; Office Visits; Outcome Measure; Outpatients; Participant; Patient Care; Patient Outcomes Assessments; Performance; Phase; Population; Psychometrics; Public Health; Recruitment Activity; Research; Risk; Schedule; Schools; Sequential Treatment; Series; Services; Severities; Signs and Symptoms; Social Network; Societies; Substance abuse problem; Suicide; System; Technology; Texas; Text; Time; Treatment outcome; United States; Universities; Validity and Reliability; Voice; Wireless Technology; Work; base; children' s depression rating scale; design; disorder later incidence prevention; experience; forgetting; improved; inventory of depressive symptomatology; medical schools; member; new technology; patient population; public health relevance; response; suicidal risk; tool

DESCRIPTION (provided by applicant): New interactive communication technologies continue to expand in modern society. Children and adolescents are frequently among the earliest adopters of new technologies. Communication via Short Message Service (SMS) "text messaging" is one example. This application proposes to develop computer-automated methods for interactively assessing clinical states in children and adolescents using dynamically branching SMS "text" messaging. Assessment of depression will be used as a template for the proposed research. Study aims are to (1) evaluate the technical feasibility of a computer-automated interactive SMS messaging system, (2) assess acceptance of the technology among depressed children and adolescents, and (3) collect reliability and validity data on a version of the Quick Inventory of Depressive Symptomatology specifically designed for use by adolescents and delivered by SMS (QIDS-A-SMS). Long-term objectives for the development of an interactive SMS technology are to provide clinically valid, widely available, internationally accessible, easily used, and user- acceptable tools for obtaining patient reported outcomes across a wide range of conditions in pediatric patient populations. If successful, the research proposed by this application will support use of the QIDS-A-SMS as a valid treatment outcome measure in pediatric antidepressant clinical trials. Twenty-five outpatients, 8-17 years old, diagnosed with major depression will be recruited from the NIH-sponsored "Pediatric MDD: Sequential Treatment with Fluoxetine and Relapse Prevention CBT" (MH039188; Dr. Graham Emslie, PI). During office visits at baseline and at the end of 6 weeks of treatment with fluoxetine, study participants will use cell phones to complete interactive QIDS-A-SMS assessments via "text replies" to a series of dynamically branching, computer-automated SMS messages. User feedback regarding the assessment experience will be collected. Independent evaluators at the University of Texas - Southwestern Medical School will also assess depression severity using the Child Depression Rating Scale-Revised (CDRS-R) for comparison with the QIDS-A-SMS data. Technical measures of system performance such at time to complete the assessments and error frequencies, user acceptance feedback, and psychometric reliability and validity of the QIDS-A-SMS will be analyzed. PUBLIC HEALTH RELEVANCE: Modern technologies, such as "text messaging" via cellular telephone, are attractive to adolescents and may provide new opportunities to provide behavioral and mental health interventions. The technology may also be helpful for assessing the impact of such interventions in pediatric populations. Major depression is a disabling condition that often begins between the ages of 15-19 years, disrupting development, impairing functioning, and increasing risk for substance abuse, suicide, and adulthood depression. Recent concerns about an increased risk of suicide in adolescents being treated with antidepressants have focused public attention on the need for closer monitoring of adolescent signs and symptoms of depression.

描述（由申请人提供）：新的互动通信技术在现代社会中继续扩展。儿童和青少年经常是新技术的最早采用者之一。通过简短消息服务（SMS）“文本消息”进行通信是一个示例。该应用程序建议开发使用动态分支SMS“文本”消息传递的计算机自动化方法，以交互式评估儿童和青少年的临床状态。抑郁症的评估将用作拟议研究的模板。研究的目的是（1）评估计算机自动互动式短信系统的技术可行性，（2）评估抑郁症的儿童和青少年对技术的接受，以及（3）在抑郁症状的快速清单上收集可靠性和有效性数据，这些抑郁症状的快速清单专门设计供青少年使用，并由SMS（Qids-smssssssssssssss）提供。开发交互式SMS技术的长期目标是提供临床上有效的，可广泛的国际访问，易于使用的，易于使用和可接受的工具，可在儿科患者人群中获得各种疾病的患者报告的结果。如果成功，则该应用程序提出的研究将支持使用QIDS-A-SMS作为小儿抗抑郁药临床试验中的有效治疗结果度量。二十五名门诊患者，8-17岁，被诊断为重度抑郁症，将从NIH赞助的“小儿MDD：用氟西汀进行顺序治疗和预防复发CBT”（MH039188； Graham Emslie博士，PI）。在基线的办公访问和氟西汀治疗6周结束时，研究参与者将使用手机通过“文本回复”来完成一系列动态分支，计算机自动化的SMS消息，以完成交互式Qids-A-SMS评估。将收集有关评估经验的用户反馈。德克萨斯大学 - 西南医学院的独立评估者还将使用儿童抑郁评级量表重新定义（CDRS-R）评估抑郁症的严重程度，以与QIDS-A-SMS数据进行比较。系统性能的技术度量将在完成评估和错误频率，用户接受反馈以及心理测量可靠性和QIDS-A-SMS的有效性。 公共卫生相关性：现代技术，例如通过蜂窝电话的“文本消息”，对青少年具有吸引力，并可能提供新的机会来提供行为和心理健康干预措施。该技术也可能有助于评估此类干预措施对小儿种群的影响。重度抑郁症是一种残疾疾病，通常从15-19岁之间开始，破坏了发展，功能障碍以及增加药物滥用，自杀和成年抑郁症的风险。最近，人们担心用抗抑郁药治疗的青少年自杀风险增加，这集中了公众的关注，需要密切监测青少年症状和抑郁症状。