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The Role of the Direct and Indirect Striatal Pathways in Movement and Learning

The Role of the Direct and Indirect Striatal Pathways in Movement and Learning
直接和间接纹状体通路在运动和学习中的作用
批准号：
8121333
负责人：
Alexxai V Kravitz
金额：
$4.84万
依托单位：
J. DAVID GLADSTONE INSTITUTES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-04-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/8121333
关键词：
AbbreviationsAddressBasal GangliaBasal Ganglia DiseasesBrainChronicComplexCorpus striatum structureDataDiseaseDisinhibitionDrug AddictionFiberFunctional disorderGlobus PallidusHuntington DiseaseIndividualLearningLesionLinkLocomotionMaintenanceModelingMotor outputMovementMusNeuronsOutcomeOutputParkinson DiseasePathway interactionsPopulationRelative (related person)ResearchResearch PersonnelRewardsRoleStimulusStructureStructure of subthalamic nucleusSubstantia nigra structureSynapsesSystemTechniquesThalamic structureawakeclassical conditioningin vivoinsightmotor controlneuronal cell bodynovelnovel strategiesopen field behaviorrelating to nervous systemresearch studyresponsesynaptic inhibitiontool

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英文摘要
DESCRIPTION (provided by applicant): Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia. PUBLIC HEALTH RELEVANCE: Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia.
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