Neuromuscular Fatigue: Age and Sex Differences

神经肌肉疲劳：年龄和性别差异

• 批准号: 8232477
• 负责人: SANDRA K HUNTER
• 金额: $ 41.09万
• 依托单位: MARQUETTE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8232477
• 关键词: Address; Adopted; Age; Aging; Alleles; Alzheimer' s Disease; American; Apolipoprotein E; Apolipoproteins; Body part; Clinical; Cognitive; Computers; Dentistry; Elderly; Equilibrium; Exercise; Exhibits; Expenditure; Fatigue; Future; Gait; Genes; Genetic; Genetic Risk; Genetic Variation; Genotype; Healthcare; Impaired cognition; Independent Living; Injury; Intervention; Intervention Studies; Life; Light; Limb structure; Longevity; Motor; Muscle; Musculoskeletal Equilibrium; Musculoskeletal Pain; Myalgia; Myopathy; Operative Surgical Procedures; Pain; Performance; Population; Predisposing Factor; Process; Rehabilitation therapy; Rheumatism; Risk; Risk Factors; Sex Characteristics; Stress; Time; Training; Upper Extremity; Woman; Work; age difference; age related; aging population; base; cognitive function; cognitive training; cost; ergonomics; innovation; men; motor impairment; musculoskeletal injury; neuromuscular; older men; older women; patient population; sex; stress management; stressor; young adult

DESCRIPTION (provided by applicant): Aging is associated with marked declines in motor performance and cognitive function, and an increase in musculoskeletal disorder and pain, especially in women. The number of Americans > 65 years in the workforce will more than double during the next 30 years so that older adults will comprise >25% of the workforce by 2050. Neuromuscular fatigue (exercise-induced loss of strength) and muscle pain that develops during low-intensity sustained postural contractions can be substantial and will increase risk of pain and injury during work-related tasks. To understand underlying factors that exacerbate fatigue with age, this proposal examines cognitive and genetic factors that contribute to greater neuromuscular fatigue and pain during static postural motor tasks of the upper limb especially in older women. We established that neuromuscular fatigability and loss of steadiness during low-intensity sustained upper limb contractions are greater for women than men when performing a challenging and stressful cognitive task. The impact of aging in older women is not known. This proposal therefore investigates the impact of age and sex on the impairment of motor performance and pain during a sustained postural fatiguing task when different levels of cognitive stress/demand are imposed. Importantly, Apolipoprotein-E e4 (APOE e4) allele inheritance conveys greater risk with increasing age of cognitive decline, and recently was associated with age-related reductions in strength. While neuromuscular fatigue exacerbates age-related decrements in strength in older adults and is likely more sensitive to APOE e4 inheritance, there are no studies addressing genetic inheritance and fatigue. This proposal also identifies whether APOE e4 contributes to differences in the magnitude of neuromuscular fatigue among older adults. Aim 1 will compare neuromuscular fatigue and pain during low-intensity postural fatiguing contractions of the upper limb in healthy young and older men and women in the presence and absence of a cognitive stressor. We hypothesize that older adults, especially women, will have greater changes in fatigue and pain when cognitive demand is increased compared with young adults. Aim 2 will determine whether the APOE e4 allele genotype is associated with age-related changes in neuromuscular fatigue and pain during low-intensity static fatiguing contractions among older men and women. We hypothesize that older adults who are APOE e4 allele carriers will exhibit the greatest fatigue and pain. This proposal adopts an innovative approach by identifying cognitive and genetic factors that predispose older adults to decrements in motor performance, increased fatigue and pain during sustained postural contractions. Identifying risk factors in older adults for motor decline will provide clinicians with a rationale to promote preventative interventions such as practice, or cognitive and physical training for sub-clinical populations before large motor function deficits occur, thus increasing productive and effective time in the work-force and more independent, healthy living in old age. PUBLIC HEALTH RELEVANCE: This proposal examines cognitive demand and genetic factors that can contribute to greater age-related neuromuscular fatigue and pain during static sustained postural fatiguing contractions of the upper limb. Sustained postural contractions are essential for daily and ergonomic tasks and increased neuromuscular fatigue place older women at greater risk of musculoskeletal injury and pain in an aging workforce. We target older adults who are genetically at risk of accelerated motor and cognitive decline (Apolipoprotein-E e4 allele positive) in order to identify healthy but subclinical older adults who are vulnerable to neuromuscular fatigue and pain when cognitive demand is imposed. The results will significantly impact treatment approaches to musculoskeletal disorders and pain and rehabilitation in an aging workforce.

描述（由申请人提供）：衰老与运动表现和认知功能的显着下降以及肌肉骨骼疾病和疼痛的增加有关，尤其是在女性中。未来 30 年，美国 65 岁以上的劳动力人数将增加一倍以上，到 2050 年，老年人将占劳动力的 25% 以上。神经肌肉疲劳（运动引起的力量丧失）和低强度持续姿势收缩期间出现的肌肉疼痛可能会很严重，并且会增加工作相关任务期间疼痛和受伤的风险。为了了解随着年龄的增长而加剧疲劳的潜在因素，该提案检查了认知和遗传因素，这些因素在上肢静态姿势运动任务期间导致更大的神经肌肉疲劳和疼痛，尤其是老年女性。我们发现，在执行具有挑战性和压力的认知任务时，女性在低强度持续上肢收缩期间的神经肌肉疲劳和稳定性丧失比男性更大。衰老对老年女性的影响尚不清楚。因此，本提案研究了在施加不同水平的认知压力/需求时，年龄和性别对持续姿势疲劳任务期间运动表现和疼痛的影响。重要的是，载脂蛋白-E e4 (APOE e4) 等位基因遗传会随着年龄的增长带来更大的认知能力下降风险，并且最近与年龄相关的力量下降有关。虽然神经肌肉疲劳会加剧老年人与年龄相关的力量下降，并且可能对 APOE e4 遗传更敏感，但目前还没有研究解决基因遗传和疲劳的问题。该提案还确定了 APOE e4 是否会导致老年人神经肌肉疲劳程度的差异。目标 1 将比较健康年轻和老年男性和女性在存在和不存在认知压力源的情况下上肢低强度姿势疲劳收缩期间的神经肌肉疲劳和疼痛。我们假设，与年轻人相比，当认知需求增加时，老年人，尤其是女性，疲劳和疼痛的变化会更大。目标 2 将确定 APOE e4 等位基因基因型是否与老年男性和女性低强度静态疲劳收缩期间神经肌肉疲劳和疼痛的年龄相关变化相关。我们假设 APOE e4 等位基因携带者的老年人会表现出最大的疲劳和疼痛。该提案采用了一种创新方法，通过识别导致老年人运动能力下降、持续姿势收缩期间疲劳和疼痛增加的认知和遗传因素。识别老年人运动衰退的危险因素将为临床医生提供一个合理的理由，以促进预防性干预措施，例如在出现大的运动功能缺陷之前对亚临床人群进行实践或认知和身体训练，从而增加劳动力的生产力和有效时间，并在老年时提供更加独立、健康的生活。 公共健康相关性：该提案研究了认知需求和遗传因素，这些因素可能导致上肢静态持续姿势疲劳收缩期间出现更大的与年龄相关的神经肌肉疲劳和疼痛。持续的姿势收缩对于日常和符合人体工程学的任务至关重要，而神经肌肉疲劳的增加使老年女性在老龄化劳动力中面临更大的肌肉骨骼损伤和疼痛风险。我们以遗传上存在运动和认知加速衰退风险（载脂蛋白-E e4 等位基因阳性）的老年人为目标，以确定在认知需求强加时容易出现神经肌肉疲劳和疼痛的健康但亚临床老年人。研究结果将显着影响老龄化劳动力中肌肉骨骼疾病、疼痛和康复的治疗方法。

项目成果

Sex Differences in Arm Muscle Fatigability With Cognitive Demand in Older Adults.

老年人手臂肌肉疲劳度与认知需求的性别差异。

• DOI: 10.1007/s11999-015-4205-1
• 发表时间: 2015
• 期刊: Clinical orthopaedics and related research
• 影响因子: 4.2
• 作者: Pereira,HugoM;Spears,VincentC;Schlinder-Delap,Bonnie;Yoon,Tejin;Harkins,April;Nielson,KristyA;HoegerBement,Marie;Hunter,SandraK
• 通讯作者: Hunter,SandraK

Force Steadiness During a Cognitively Challenging Motor Task Is Predicted by Executive Function in Older Adults.

老年人执行功能可预测认知挑战性运动任务期间的力量稳定性。

• DOI: 10.3389/fphys.2018.01316
• 发表时间: 2018
• 期刊: Frontiers in physiology
• 影响因子: 4
• 作者: Pereira,HugoM;Schlinder-Delap,Bonnie;Nielson,KristyA;Hunter,SandraK
• 通讯作者: Hunter,SandraK

Oscillations in neural drive and age-related reductions in force steadiness with a cognitive challenge.

神经驱动力的振荡和与年龄相关的力量稳定性的降低以及认知挑战。

• DOI: 10.1152/japplphysiol.00821.2018
• 发表时间: 2019
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Pereira,HugoM;Schlinder-DeLap,Bonnie;Keenan,KevinG;Negro,Francesco;Farina,Dario;Hyngstrom,AllisonS;Nielson,KristyA;Hunter,SandraK
• 通讯作者: Hunter,SandraK