15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India

第十五届共济失调毛细血管扩张和 ATM 国际研讨会将在印度举行

• 批准号: 8257390
• 负责人: Tej K Pandita
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257390
• 关键词: Achievement; Address; Area; Asians; Ataxia Telangiectasia; Australia; Awareness; Basic Science; Breast; Cell physiology; Cerebellar Ataxia; Chromatin Structure; Clinical; Clinical Treatment; Clinical Trials; Collaborations; Complex; Country; DNA; DNA Damage; DNA Repair; Development; Diagnosis; Disease; Drug Delivery Systems; Educational workshop; Ensure; Event; Fostering; Funding Applicant; Future; Genomic Instability; Goals; HIV; Habitats; Human; Immune; Immune system; Immunity; Immunologic Deficiency Syndromes; Immunology; Incidence; Influenza; Inherited; Injury; International; Ionizing radiation; Knowledge; Left; Letters; Location; Malignant Neoplasms; Medical; Molecular; Mutation; Nerve Degeneration; Nervous system structure; Pathology; Pathway interactions; Patients; Pharmaceutical Preparations; Phenotype; Population; Postdoctoral Fellow; Proteins; Radiation Tolerance; Radiation therapy; Reporting; Research; Research Personnel; Research Training; Role; Scientist; Signal Transduction; Signaling Protein; Site; Stem cells; Structure; Students; Suggestion; Time; Viral; Virus Diseases; Visit; Work; abstracting; ataxia telangiectasia mutated protein; base; cancer risk; cancer therapy; career; cost; cost effectiveness; interest; malignant neurologic neoplasms; meetings; nervous system disorder; neuropathology; new therapeutic target; peer; planetary Atmosphere; posters; relating to nervous system; response; role model; success; symposium; treatment trial; web site

DESCRIPTION (provided by applicant): Funds are requested for partial support towards the 15th International Workshop on Ataxia- Telangiectasia and ATM, (ATW2012) which wil be held at the India Habitat Center, Delhi, India (http://www.indiahabitat.org/) on February 07-11, 2012. "As outgoing Chair (Richard Gatti), I am fulfilling my last duty, that of reporting on a recent tri to India to evaluate the feasibility and advisability of holding the next A-T Workshop (ATW2012) in New Delhi, India, under the direction of Tej Pandita. The official target date is February 7-11, 2012. During my short visit to Delhi, we looked at several very acceptable sites with which each of you would be quite pleased (Appendix 1)". We expect to have approximately 60 speakers; half being selected by the Organizing Committee, while the other half will come from abstracts submitted in response to an AT/ATM-focused list of topics posted on the conference website. The remaining abstracts will be presented as posters, 150 of which can be accommodated. Ataxia-telangiectasia (A-T) is a complex autosomal recessive disorder that is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, ionizing radiation sensitivity, and a markedly increased incidence of cancer. In addition, ATM (ataxia-telangiectasia mutated) was recently shown to have a role in viral integration which may provide a new therapeutic target for controlling important viral infections, such as HIV and influenza. The objectives of the meeting to be held in India are to bring together basic and clinical researchers, especially younger investigators, working on various aspects of the clinical and cellular phenotypes of ATM/atm-deficient models, the role of ATM in neural differentiation and development, immunology and the ATM role in the DNA damage response. The local organizing committee constituted of eminent group of scientists with their office in Delhi will make all the necessary arrangements for the success of the proposed meeting (see letter of commitment: Appendix 2). By providing a comprehensive and stimulating atmosphere, the ATW2012 Workshop organizers will promote scientific interactions, discussions and cross-disciplinary research collaborations among scientists from different continents and increase awareness in the Asian continent about the ATM disease, treatment, possibilities for A-T patients and the cellular/molecular basis underlying ATM related pathologies. Specific areas of focus of the meeting will include the role of ATM in the nervous system, mechanisms of neurodegeneration, the role of DNA signaling proteins in neuropathology as well as breast and other human cancers, and the development of new drugs that could correct the effects of specific types of ATM mutations that cause A-T. This will be the first A-T Workshop that provides a forum to discuss the near term potential for applying the results from basic ATM studies to possible A-T clinical treatment trials and, in the future, other neurological diseases. PUBLIC HEALTH RELEVANCE: The goal of this international workshop is to bring together established and developing basic and clinical scientists from various countries together to participate in highly interactive scientific discourses through the presentation of their findings and dissemination of knowledge to generate awareness about the ATM related disorder in India, which represents a large population.

描述（由申请人提供）：申请资金用于部分支持第15届共济失调-毛细血管扩张和ATM国际研讨会（ATW 2012），该研讨会将于2012年2月7日至11日在印度德里的印度人居中心（http：//www.indiahabitat.org/）举行。“作为即将离任的主席（Richard Gatti），我正在履行我的最后一项职责，即报告最近前往印度的旅行，以评估在Tej Pandita的指导下在印度新德里举办下一届A-T研讨会（ATW 2012）的可行性和可行性。官方目标日期为2012年2月7日至11日。在我对德里的短暂访问中，我们考察了几个非常可以接受的地点，你们每个人都会很满意（附录1）。我们预计将有大约60名发言者;一半由组织委员会选出，另一半将来自根据会议网站上张贴的AT/ATM主题清单提交的摘要。其余的摘要将以海报形式呈现，可容纳150份。 共济失调-毛细血管扩张症（A-T）是一种复杂的常染色体隐性遗传疾病，其特征在于进行性小脑共济失调、毛细血管扩张、免疫缺陷、基因组不稳定、电离辐射敏感性和癌症发病率显著增加。此外，ATM（共济失调-毛细血管扩张突变）最近被证明在病毒整合中具有作用，这可能为控制重要的病毒感染（如HIV和流感）提供新的治疗靶点。 将在印度举行的会议的目标是汇集基础和临床研究人员，特别是年轻的研究人员，研究ATM/ATM缺陷模型的临床和细胞表型的各个方面，ATM在神经分化和发育中的作用，免疫学和ATM在DNA损伤反应中的作用。由著名科学家组成的当地组织委员会，其办公室设在德里，将为拟议会议的成功作出一切必要的安排（见承诺书：附录2）。通过提供一个全面和刺激的氛围，ATW 2012研讨会组织者将促进来自不同大陆的科学家之间的科学互动，讨论和跨学科研究合作，并提高亚洲大陆对ATM疾病，治疗，A-T患者的可能性以及ATM相关病理学的细胞/分子基础的认识。会议的具体重点领域将包括ATM在神经系统中的作用，神经变性的机制，DNA信号蛋白在神经病理学以及乳腺癌和其他人类癌症中的作用，以及开发可以纠正导致A-T的特定类型ATM突变的影响的新药。这将是第一次A-T研讨会，提供一个论坛，讨论将基础ATM研究结果应用于可能的A-T临床治疗试验以及未来其他神经系统疾病的近期潜力。 公共卫生相关性：这个国际研讨会的目标是汇集来自不同国家的基础和临床科学家，通过介绍他们的发现和传播知识，参与高度互动的科学讨论，以提高对印度ATM相关疾病的认识，这代表了一个庞大的人口。