15th International Workshop on Ataxia-Telangiectasia and ATM to be held in India

描述（由申请人提供）：申请资金用于第15届共济失调-毛细血管扩张和ATM国际研讨会（ATW2012）的部分支持，该研讨会将于2012年2月7日至11日在印度德里的印度栖息地中心举行（http://www.indiahabitat.org/）。“作为即将离任的主席（Richard Gatti），我正在履行我的最后职责，即在Tej Pandita的指导下，就最近前往印度评估在印度新德里举行下一届a - t研讨会（ATW2012）的可行性和明智性进行报告。官方的目标日期是2012年2月7日至11日。在我对德里的短暂访问期间，我们看了几个非常可以接受的地方，你们每个人都会很满意（附录1）。”我们预计会有大约60位演讲者；一半由组委会选出，另一半将来自对会议网站上发布的以自动取款机为重点的主题列表所提交的摘要。其余的摘要将以海报形式展示，可容纳150份。共济失调-毛细血管扩张症（a-t）是一种复杂的常染色体隐性遗传病，其特征是进行性小脑共济失调、毛细血管扩张、免疫缺陷、基因组不稳定、电离辐射敏感性和癌症发病率显著增加。此外，ATM（共济失调-毛细血管扩张突变）最近被证明在病毒整合中起作用，这可能为控制重要的病毒感染（如HIV和流感）提供新的治疗靶点。在印度举行的会议的目标是汇集基础和临床研究人员，特别是年轻的研究人员，他们致力于ATM/ ATM缺陷模型的临床和细胞表型的各个方面，ATM在神经分化和发育中的作用，免疫学和ATM在DNA损伤反应中的作用。由著名科学家组成的当地组织委员会在德里设有办事处，将为拟议会议的成功作出所有必要的安排（见承诺书：附录2）。通过提供一个全面和刺激的氛围，ATW2012研讨会组织者将促进来自不同大陆的科学家之间的科学互动、讨论和跨学科研究合作，并提高亚洲大陆对ATM疾病、治疗、a - t患者的可能性以及ATM相关病理的细胞/分子基础的认识。会议的具体重点领域将包括ATM在神经系统中的作用，神经退行性变的机制，DNA信号蛋白在神经病理学以及乳腺癌和其他人类癌症中的作用，以及可以纠正导致A-T的特定类型ATM突变影响的新药的开发。这将是第一个人工智能研讨会，它提供了一个论坛，讨论将ATM基础研究结果应用于可能的人工智能临床治疗试验的近期潜力，并在未来应用于其他神经系统疾病。

DESCRIPTION (provided by applicant): Funds are requested for partial support towards the 15th International Workshop on Ataxia- Telangiectasia and ATM, (ATW2012) which wil be held at the India Habitat Center, Delhi, India (http://www.indiahabitat.org/) on February 07-11, 2012. "As outgoing Chair (Richard Gatti), I am fulfilling my last duty, that of reporting on a recent tri to India to evaluate the feasibility and advisability of holding the next A-T Workshop (ATW2012) in New Delhi, India, under the direction of Tej Pandita. The official target date is February 7-11, 2012. During my short visit to Delhi, we looked at several very acceptable sites with which each of you would be quite pleased (Appendix 1)". We expect to have approximately 60 speakers; half being selected by the Organizing Committee, while the other half will come from abstracts submitted in response to an AT/ATM-focused list of topics posted on the conference website. The remaining abstracts will be presented as posters, 150 of which can be accommodated. Ataxia-telangiectasia (A-T) is a complex autosomal recessive disorder that is characterized by a progressive cerebellar ataxia, telangiectasia, immunodeficiency, genomic instability, ionizing radiation sensitivity, and a markedly increased incidence of cancer. In addition, ATM (ataxia-telangiectasia mutated) was recently shown to have a role in viral integration which may provide a new therapeutic target for controlling important viral infections, such as HIV and influenza. The objectives of the meeting to be held in India are to bring together basic and clinical researchers, especially younger investigators, working on various aspects of the clinical and cellular phenotypes of ATM/atm-deficient models, the role of ATM in neural differentiation and development, immunology and the ATM role in the DNA damage response. The local organizing committee constituted of eminent group of scientists with their office in Delhi will make all the necessary arrangements for the success of the proposed meeting (see letter of commitment: Appendix 2). By providing a comprehensive and stimulating atmosphere, the ATW2012 Workshop organizers will promote scientific interactions, discussions and cross-disciplinary research collaborations among scientists from different continents and increase awareness in the Asian continent about the ATM disease, treatment, possibilities for A-T patients and the cellular/molecular basis underlying ATM related pathologies. Specific areas of focus of the meeting will include the role of ATM in the nervous system, mechanisms of neurodegeneration, the role of DNA signaling proteins in neuropathology as well as breast and other human cancers, and the development of new drugs that could correct the effects of specific types of ATM mutations that cause A-T. This will be the first A-T Workshop that provides a forum to discuss the near term potential for applying the results from basic ATM studies to possible A-T clinical treatment trials and, in the future, other neurological diseases.