Effects of dietary soy compounds on stroke outcomes

膳食大豆化合物对中风结果的影响

基本信息

项目摘要

DESCRIPTION (provided by applicant): Stroke is a leading cause of lasting disability in humans and is the third leading cause of death among adults in the United States of America. Nearly 800,000 Americans are stricken by ischemic stroke each year. For this reason, the development of novel strategies for use in limiting the devastating outcomes of stroke is a key priority for the National Institutes of Health. Dietary changes represent potential, minimally invasive routes to reduce both the risk and negative outcomes of stroke. The aim of the current project is to examine the potential benefits and mechanism of action in the post-stroke brain of animals fed diets containing soy isoflavones and/or soy protein isolate. Understanding the mechanism(s) through which soy- based neuroprotection is achieved may aid in reducing life-altering outcomes for populations at risk of stroke since lifestyle changes - like adding more soy protein and/or soy isoflavones to one's diet - represent non-invasive strategies which can be adopted by those most at risk. PUBLIC HEALTH RELEVANCE: Occlusive stroke is a devastating event which often results in permanent loss of motor and cognitive function which can reduce quality of life measures in humans. The experiments in the current application will provide a better understanding of the benefits of diets containing soy isoflavones and/or soy protein isolate in the stroke-injured cerebral cortex. The results of these experiments will aid in developing strategies aimed at reducing the impact of strokes, and enhancing recovery from the lasting debilitations which often follow stroke in human patients.
描述(由申请人提供):中风是人类持久残疾的主要原因,也是美国成年人死亡的第三大原因。每年有近80万美国人患缺血性中风。出于这个原因,开发新的策略用于限制中风的破坏性结果是美国国立卫生研究院的一个关键优先事项。饮食改变是潜在的微创途径,可降低卒中的风险和不良结局。目前项目的目的是研究含有大豆异黄酮和/或大豆蛋白分离物的饲料对动物中风后大脑的潜在益处和作用机制。了解大豆神经保护作用的实现机制可能有助于减少中风风险人群的生活改变结果,因为生活方式的改变-如在饮食中添加更多的大豆蛋白和/或大豆异黄酮-代表了那些风险最大的人可以采用的非侵入性策略。 公共卫生关系:闭塞性卒中是一种破坏性事件,其通常导致运动和认知功能的永久性丧失,这可以降低人类的生活质量。本申请中的实验将提供对含有大豆异黄酮和/或大豆蛋白分离物的饮食在中风损伤的大脑皮层中的益处的更好理解。这些实验的结果将有助于开发旨在减少中风影响的策略,并促进从人类患者中风后经常出现的持久衰弱中恢复。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of Dietary Soy Protein Isolate Versus Isoflavones Alone on Poststroke Skilled Ladder Rung Walking and Cortical mRNA Expression Differ in Adult Male Rats.
膳食大豆分离蛋白与单独的异黄酮对成年雄性大鼠中风后熟练梯级行走和皮质 mRNA 表达的影响不同。
  • DOI:
    10.1089/jmf.2020.0218
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Grisley,ElizabethDawn;Huber,KaleneN;Knapp,AustenN;Butteiger,DustieN;Banz,WilliamJ;MacLean,JamesA;Wallace,DouglasG;Cheatwood,JosephL
  • 通讯作者:
    Cheatwood,JosephL
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Joseph L Cheatwood其他文献

Joseph L Cheatwood的其他文献

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