Effects of dietary soy compounds on stroke outcomes

描述(申请人提供)：中风是导致人类永久性残疾的主要原因，也是美利坚合众国成年人死亡的第三大原因。每年有近80万美国人遭受缺血性中风的打击。出于这个原因，开发用于限制中风破坏性后果的新策略是美国国立卫生研究院的关键优先事项。改变饮食是降低中风风险和不良后果的潜在、微创途径。本项目的目的是研究饲喂含有大豆异黄酮和/或大豆分离蛋白的饲料的动物在中风后大脑中的潜在益处和作用机制。了解大豆神经保护的实现机制(S)可能有助于减少中风风险人群改变生活的结果，因为生活方式的改变--比如在饮食中增加更多大豆蛋白和/或大豆异黄酮--代表了非侵入性策略，最有风险的人可以采用这些策略。 公共卫生相关性：闭塞性中风是一种破坏性事件，通常会导致运动和认知功能的永久性丧失，从而降低人类的生活质量指标。目前应用中的实验将更好地了解含有大豆异黄酮类和/或大豆分离蛋白的饮食对中风损伤大脑皮层的好处。这些实验的结果将有助于制定旨在减少中风影响的策略，并促进人类患者中风后经常出现的持久虚弱的恢复。

DESCRIPTION (provided by applicant): Stroke is a leading cause of lasting disability in humans and is the third leading cause of death among adults in the United States of America. Nearly 800,000 Americans are stricken by ischemic stroke each year. For this reason, the development of novel strategies for use in limiting the devastating outcomes of stroke is a key priority for the National Institutes of Health. Dietary changes represent potential, minimally invasive routes to reduce both the risk and negative outcomes of stroke. The aim of the current project is to examine the potential benefits and mechanism of action in the post-stroke brain of animals fed diets containing soy isoflavones and/or soy protein isolate. Understanding the mechanism(s) through which soy- based neuroprotection is achieved may aid in reducing life-altering outcomes for populations at risk of stroke since lifestyle changes - like adding more soy protein and/or soy isoflavones to one's diet - represent non-invasive strategies which can be adopted by those most at risk. PUBLIC HEALTH RELEVANCE: Occlusive stroke is a devastating event which often results in permanent loss of motor and cognitive function which can reduce quality of life measures in humans. The experiments in the current application will provide a better understanding of the benefits of diets containing soy isoflavones and/or soy protein isolate in the stroke-injured cerebral cortex. The results of these experiments will aid in developing strategies aimed at reducing the impact of strokes, and enhancing recovery from the lasting debilitations which often follow stroke in human patients.