2012 Gordon Research Conference and Gordon-Kenan Research Seminar on Plasminogen

描述（由申请人提供）： 资金寻求部分支持的“戈登研究会议纤溶酶原激活和胞外蛋白水解”（GRC），并为相关的“戈登凯南研究生研究研讨会纤溶酶原激活和胞外蛋白水解”（GRS）的部分支持。这些是在同一地点依次举行的配对会议，2012年2月11日和12日为GRS，2月12日至17日为GRC。自1990年以来，GRC每两年连续举办一次，在国际上享有盛誉。它汇集了一群具有不同科学背景的高度积极性的参与者，他们以“非正式”的方式在与纤溶酶原激活系统和相关细胞外蛋白酶相关的研究前沿进行了深入而非正式的讨论。因此，会议为来自广泛学科的世界领先研究人员提供了一个独特的机会，展示他们与纤溶酶原激活和细胞外蛋白水解相关的最新未发表的研究，并讨论将他们的研究转化为新疗法的创新方法。在这一领域的先前研究已经导致了组织纤溶酶原激活剂的开发，用于成功治疗广泛的血栓栓塞性疾病，并发现纤溶酶原激活系统细胞外蛋白水解在许多生理和病理过程中的重要作用。将要讨论的研究领域包括血管生物学中的纤溶酶原激活和细胞外蛋白水解、中枢神经系统功能和功能障碍、阿尔茨海默病、组织稳态和再生、造血、干细胞生物学、代谢和肥胖、肿瘤生物学、心血管功能和血管生成。与会者将通过邀请和在线提交的申请进行选择。他们将被选为代表不同领域的研究人员，并强调将妇女和代表性不足的少数民族作为讨论领导者，演讲者，海报展示者和与会者。相关的GRS是一个新颖的功能，将为年轻科学家提供一个独特的机会，分享GRC的经验。这个为期两天的研讨会将由研究生和博士后研究员在领先研究人员的支持下组织，并将允许纤溶酶原激活和细胞外蛋白水解领域的初级研究人员聚集在一起讨论他们目前的研究，同时与同行建立非正式网络，这可能会导致终身的合作和科学成就。

DESCRIPTION (provided by applicant): Funds are sought for partial support of the "Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis" (GRC), and for partial support of the associated "Gordon-Kenan Graduate Research Seminar on Plasminogen Activation and Extracellular Proteolysis" (GRS). These are paired conferences held sequentially at the same location, February 11, 12, 2012 for the GRS, and February 12-17 for the GRC. The GRC has been held continuously every two years since 1990 and enjoys an outstanding international reputation. It brings together a group of highly motivated participants with diverse scientific backgrounds that engage in intensive, yet informal, discussions at the frontier of research related to the plasminogen activation system and associated extracellular proteases in an "off-the-record" fashion. The conference thus provides a unique opportunity for the leading researchers in the world from a broad range of disciplines to present their latest unpublished research related to plasminogen activation and extracellular proteolysis, and to discuss innovative ways to translate their research into new therapies. Previous research in this area has led to the development of tissue plasminogen activator for the successful treatment of a wide range of thromboembolic disorders, and the discovery of important roles for the plasminogen activation system extracellular proteolysis in a number of physiologic and pathologic processes. Research areas to be discussed include plasminogen activation and extracellular proteolysis in vascular biology, central nervous system function and dysfunction, Alzheimer's disease, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, cardiovascular function, and angiogenesis. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of researchers, and a strong emphasis will be made on the inclusion of women and underrepresented minorities as Discussion Leaders, Speakers, Poster Presenters, and Attendees. The associated GRS is a novel feature that will provide a unique opportunity for young scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.