2012 Gordon Research Conference and Gordon-Kenan Research Seminar on Plasminogen

描述(由申请人提供)： 为“关于纤溶酶原激活和胞外蛋白分解的戈登研究会议”(GRC)和相关的“戈登-凯南关于纤溶酶原激活和胞外蛋白分解的研究生研究研讨会”(GRS)提供部分支持。这些是在同一地点连续举行的配对会议，2012年2月11日、12日为GRS，2月12日至17日为GRC。GRC自1990年以来每两年连续举办一次，在国际上享有盛誉。它聚集了一群具有不同科学背景的高度积极的参与者，他们在与纤溶酶原激活系统和相关的细胞外蛋白水解酶相关的研究前沿以“非正式”的方式进行密集但非正式的讨论。因此，这次会议为来自广泛学科的世界领先研究人员提供了一个独特的机会，展示他们关于纤溶酶原激活和细胞外蛋白分解的最新未发表研究，并讨论将他们的研究转化为新疗法的创新方法。组织纤溶酶原激活剂在这一领域的研究已经成功地治疗了广泛的血栓栓塞性疾病，并发现了纤溶酶原激活系统胞外蛋白分解在许多生理和病理过程中的重要作用。将讨论的研究领域包括血管生物学中的纤溶酶原激活和细胞外蛋白分解、中枢神经系统功能和功能障碍、阿尔茨海默病、组织动态平衡和再生、造血、干细胞生物学、新陈代谢和肥胖、肿瘤生物学、心血管功能和血管生成。与会者将通过邀请和在线提交的申请进行选择。他们将被选为代表不同研究人员的代表，并将大力强调将妇女和代表性不足的少数群体纳入讨论领导者、演讲者、海报主持人和与会者。相关的GRS是一项新颖的功能，将为年轻科学家提供一个分享GRC经验的独特机会。这个为期两天的研讨会将由研究生和博士后研究员在领先研究人员的支持下组织，并将允许纤溶酶原激活和细胞外蛋白分解领域的初级研究人员聚集在一起讨论他们目前的研究，同时与他们的同行建立非正式的网络，可能导致终身合作和科学成就。

DESCRIPTION (provided by applicant): Funds are sought for partial support of the "Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis" (GRC), and for partial support of the associated "Gordon-Kenan Graduate Research Seminar on Plasminogen Activation and Extracellular Proteolysis" (GRS). These are paired conferences held sequentially at the same location, February 11, 12, 2012 for the GRS, and February 12-17 for the GRC. The GRC has been held continuously every two years since 1990 and enjoys an outstanding international reputation. It brings together a group of highly motivated participants with diverse scientific backgrounds that engage in intensive, yet informal, discussions at the frontier of research related to the plasminogen activation system and associated extracellular proteases in an "off-the-record" fashion. The conference thus provides a unique opportunity for the leading researchers in the world from a broad range of disciplines to present their latest unpublished research related to plasminogen activation and extracellular proteolysis, and to discuss innovative ways to translate their research into new therapies. Previous research in this area has led to the development of tissue plasminogen activator for the successful treatment of a wide range of thromboembolic disorders, and the discovery of important roles for the plasminogen activation system extracellular proteolysis in a number of physiologic and pathologic processes. Research areas to be discussed include plasminogen activation and extracellular proteolysis in vascular biology, central nervous system function and dysfunction, Alzheimer's disease, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, cardiovascular function, and angiogenesis. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of researchers, and a strong emphasis will be made on the inclusion of women and underrepresented minorities as Discussion Leaders, Speakers, Poster Presenters, and Attendees. The associated GRS is a novel feature that will provide a unique opportunity for young scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.