2010 Gordon Research Conference on Plasminogen Activation and Ertracellular Prote

描述（由申请人提供）： 资金寻求部分支持的“戈登研究会议纤溶酶原激活和细胞外蛋白水解”（GRC），这是将于2010年2月14日至19日在文图拉，加州。资金也寻求部分支持相关的“戈登凯南研究生研究研讨会纤溶酶原激活和胞外蛋白水解”（GRS）将于2月12日至13日在同一地点举行。自1990年以来，GRC每两年连续举办一次，在国际上享有盛誉。它汇集了一群具有不同科学背景的高度积极性的参与者，他们以“非正式”的方式在与纤溶酶原激活系统和相关细胞外蛋白酶相关的研究前沿进行了深入而非正式的讨论。因此，该会议为来自广泛学科的世界领先研究人员提供了一个独特的机会，展示他们与纤溶酶原激活和细胞外蛋白水解相关的最新未发表的研究，并讨论将他们的研究转化为新疗法的创新方法。在这一领域的先前研究已经导致了组织纤溶酶原激活剂的开发，用于成功治疗广泛的血栓栓塞性疾病。将要讨论的研究领域包括纤溶酶原激活和细胞外蛋白水解溶栓，血管生物学，中枢神经系统功能和功能障碍，组织稳态和再生，造血，干细胞生物学，代谢和肥胖，肿瘤生物学和血管生成。与会者将通过邀请和在线提交的申请进行选择。他们将被选为代表不同领域的研究人员，并强调将妇女和代表性不足的少数民族作为讨论领导者，演讲者，海报展示者和与会者。相关的GRS是一个新颖的功能，将为年轻科学家提供一个独特的机会，分享GRC的经验。这个为期两天的研讨会将由研究生和博士后研究员在领先研究人员的支持下组织，并将允许纤溶酶原激活和细胞外蛋白水解领域的初级研究人员聚集在一起讨论他们目前的研究，同时与同行建立非正式网络，这可能会导致终身的合作和科学成就。公共卫生相关性：纤溶酶原激活和细胞外蛋白水解是与基础科学和临床研究交叉的快速发展的研究领域。这些领域的研究对于开发治疗与循环系统相关的各种疾病的新方法具有独特的重要性，包括心脏病发作，深静脉血栓形成和闭塞性中风。会议将汇集世界领先的研究人员，讨论他们在这一领域的最新研究，目的是将这些发现转化为新的和更好的人类疾病治疗方法。

DESCRIPTION (provided by applicant): Funds are sought for partial support of the "Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis" (GRC), which is to be held February 14-19, 2010 in Ventura, California. Funds are also sought for partial support of the associated "Gordon-Kenan Graduate Research Seminar on Plasminogen Activation and Extracellular Proteolysis" (GRS) to be held February 12-13 at the same location. The GRC has been held continuously every two years since 1990 and enjoys an outstanding international reputation. It brings together a group of highly motivated participants with diverse scientific backgrounds that engage in intensive, yet informal, discussions at the frontier of research related to the plasminogen activation system and associated extracellular proteases in an "off-the- record" fashion. The conference thus provides a unique opportunity for the leading researchers in the world from a broad span of disciplines to present their latest unpublished research related to plasminogen activation and extracellular proteolysis, and discuss innovative ways to translate their research into new therapies. Previous research in this area has led to the development of tissue plasminogen activator for the successful treatment of a wide range of thromboembolic disorders. Research areas to be discussed include plasminogen activation and extracellular proteolysis in thrombolysis, vascular biology, central nervous system function and dysfunction, tissue homeostasis and regeneration, hematopoiesis, stem cell biology, metabolism and obesity, tumor biology, and angiogenesis. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of researchers, and a strong emphasis will be made on the inclusion of women and underrepresented minorities as Discussion Leaders, Speakers, Poster Presenters, and Attendees. The associated GRS is a novel feature that will provide a unique opportunity for young scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement. PUBLIC HEALTH RELEVANCE: Plasminogen activation and extracellular proteolysis are rapidly advancing research areas that intersect with basic science and clinical research. Research in these areas is uniquely important for the development of new ways to treat a wide range of disorders related to the circulatory system, including heart attack, deep vein thrombosis, and occlusive stroke. The conference will bring together the leading researchers in the world to discuss their latest research in this area, with the goal of translating these discoveries into new and better treatment of human disease.