2011 Gradient Sensing and Directed Cell Migration Gordon Research Conference

2011 梯度传感和定向细胞迁移戈登研究会议

• 批准号: 8128064
• 负责人: TOBIAS MEYER
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128064
• 关键词: Address; Allergic Disease; Animal Model; Area; Arthritis; Asthma; Basic Science; Biological Models; Biomedical Engineering; Cardiovascular Diseases; Cell Polarity; Cells; Chemotaxis; Collaborations; Complex; Cytoskeleton; Development; Dictyostelium; Discipline; Disease; Environment; Goals; Growth Cones; Health; Human; Immigration; Immune; Immunologic Deficiency Syndromes; Inflammation; Inflammatory; Intention; Leukocyte Trafficking; Link; Malignant Neoplasms; Modeling; Neoplasm Metastasis; Nerve Degeneration; Neurons; Pathogenesis; Pathway interactions; Public Health; Research; Research Personnel; Rheumatism; Scholarship; Scientist; Signal Transduction; Switzerland; System; Underrepresented Minority; Woman; Wound Healing; abstracting; axonal guidance; cell motility; human disease; improved; meetings; neuron development; novel; novel strategies; novel therapeutics; polarized cell; posters; programs; symposium; therapeutic development; trafficking

DESCRIPTION (provided by applicant): The 2011 Gordon Research Conference (GRC) on Gradient Sensing and Directed Cell Migration will be held from June 5-10, 2011 at Les Diablerets Conference Center in Les Diablerets, Switzerland. This conference will follow three successful Gordon Conferences in the field of chemotaxis research, which have been held every two years since 2005. The conference addresses the basic research question of how cells polarize and migrate directionally in diverse systems by discussing development, neuronal path finding, leukocyte trafficking, wound healing, tissue repair, and cancer. The conference is also relevant to the development of therapeutics aimed at disorders where cell migration is central to disease pathogenesis including: cardiovascular diseases, rheumatic and allergic diseases, asthma, and cancer. The program highlights the commonality of mechanisms that regulate directed cell migration in the context of diverse systems and the implications of these common pathways to the development of disease. The conference will emphasize new concepts about the basic mechanisms that regulate gradient sensing and directed cell migration, and will explore links between cell migration during development, wound healing, immune cell trafficking, and cancer. Nine discussion sessions are planned: (1) Directed Cell Migration in Cancer, (2) Neuronal Polarity and Growth Cone Guidance (3) Directed Cell Migration in Animal Model Systems, (4) Collective Migration in Development and Wound Healing, (5) Inflammation and Leukocyte Trafficking, (6) Cell Signaling in Chemotaxis, (7) Cell Polarity and the Cytoskeleton in Directed Cell Migration, (8) Quantitative Modeling of Directed Cell Migration. The combination of speakers and topics has been selected with the specific intention of stimulating new ideas and collaborations in the field of chemotaxis research. The session speakers, selected from a variety of fields, will emphasize novel, unpublished results directly related to gradient sensing and directed cell migration. Young investigators will be encouraged to present and discuss their findings in a supportive environment through the invitation of up to 20 additional speakers, selected from submitted abstracts, and by participation in the posters sessions. Scholarships will be offered to encourage the attendance of young scientists, women and underrepresented minorities. Throughout the conference, interactions between senior and young investigators will be promoted in both formal and informal settings. Support of this program will assure that the meeting will be successful and will provide much needed sponsorship for outstanding young scientists who wish to attend. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Gradient Sensing and Directed Cell Migration addresses the fundamental mechanisms that regulate directed cell migration and axonal path finding. This area of research has substantial importance to the development of new therapeutics to treat a diverse array of human diseases including cancer, cardiovascular disease, arthritis, asthma and neuronal degeneration. This conference will bring together experts who study directed cell migration mechanisms in simple and complex systems in order to stimulate new ideas and advance our abilities to improve public health.

描述（由申请人提供）：2011年戈登研究会议（GRC）梯度传感和定向细胞迁移将于2011年6月5日至10日在Les Diablerets会议中心举行，瑞士。本次会议将遵循三个成功的戈登会议在趋化性研究领域，自2005年以来每两年举行一次。会议通过讨论发育、神经元路径发现、白细胞运输、伤口愈合、组织修复和癌症，解决了细胞如何在不同系统中定向迁移的基本研究问题。该会议还与针对细胞迁移是疾病发病机制核心的疾病的治疗方法的发展有关，包括心血管疾病，风湿性和过敏性疾病，哮喘和癌症。该计划强调了在不同系统的背景下调节定向细胞迁移的机制的共同性以及这些共同途径对疾病发展的影响。会议将强调有关调节梯度感应和定向细胞迁移的基本机制的新概念，并将探讨发育过程中细胞迁移、伤口愈合、免疫细胞贩运和癌症之间的联系。计划举行九次讨论会：（1）癌症中的定向细胞迁移，（2）神经元极性和生长锥引导，（3）动物模型系统中的定向细胞迁移，（4）发育和伤口愈合中的集体迁移，（5）炎症和白细胞运输，（6）趋化性中的细胞信号传导，（7）定向细胞迁移中的细胞极性和细胞骨架，（8）定向细胞迁移的定量建模。选择演讲者和主题的组合是为了激发趋化性研究领域的新想法和合作。从各个领域选出的会议发言人将强调与梯度传感和定向细胞迁移直接相关的新颖的未发表的结果。将通过邀请从提交的摘要中选出的最多20名发言者和参加海报会议，鼓励年轻的研究人员在一个支持性的环境中介绍和讨论他们的研究结果。将提供奖学金，以鼓励年轻科学家、妇女和代表性不足的少数民族参加。在整个会议期间，将在正式和非正式场合促进高级和年轻调查人员之间的互动。对该计划的支持将确保会议取得成功，并将为希望参加会议的杰出青年科学家提供急需的赞助。 公共卫生相关性：戈登梯度感应和定向细胞迁移研究会议解决了调节定向细胞迁移和轴突路径发现的基本机制。这一研究领域对于开发新疗法以治疗多种人类疾病具有重要意义，包括癌症、心血管疾病、关节炎、哮喘和神经元变性。本次会议将汇集研究简单和复杂系统中定向细胞迁移机制的专家，以激发新的想法并提高我们改善公共卫生的能力。