Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias

了解心脏兴奋收缩和心律失常的系统方法

• 批准号: 8319967
• 负责人: Donald M Bers
• 金额: $ 0.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319967
• 关键词: Adult; Animal Model; Applications Grants; Area; Arrhythmia; Biomedical Engineering; California; Cardiac; Cardiac Myocytes; Cardiology; Cells; Clinical; Complex; Computer Simulation; Consensus; Contractile System; Coupling; Data; Developed Countries; Disease; Doctor of Philosophy; Drug Formulations; Educational workshop; Electrophysiology (science); Faculty; Feedback; Goals; Health; Heart; Heart Diseases; Heart failure; Human; Knowledge; Medicine; Modeling; Molecular; Oral; Organ; Paper; Parents; Participant; Patients; Pharmacology; Population; Principal Investigator; Property; Research; Research Personnel; San Francisco; Series; Signal Transduction; Societies; Students; Study models; System; Testing; Time; Tissues; United States National Institutes of Health; Universities; Work; combat; computerized tools; effective therapy; experience; heart function; heart rhythm; interdisciplinary collaboration; mathematical model; meetings; muscular system; novel therapeutics; pre-doctoral; research study; success; symposium

DESCRIPTION (provided by applicant): NIH Support for Conferences and Scientific Meetings (A-0-01 Parent R13/U13) Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias Multiple Principal Investigators: Donald M Bers, PhD, Ye Chen-Izu, PhD, Nipavan Chiamvimonvat, MD, and Leighton T Izu, PhD Departments of Pharmacology, Biomedical Engineering, Medicine/Cardiology, University of California Davis ABSTRACT Heart diseases such as arrhythmias and heart failure are the No.1 killer of the adult population in US and developed countries. To develop better and more effective therapies to combat heart diseases, it is critically important to gain more accurate and deeper understanding of the disease mechanisms. In the recent several decades, researchers have made important conceptual advances and accumulated large amounts of experimental data on the inner workings of the heart at molecular, cellular and whole organ levels. It is important now to enhance the integration of this rich experimental data into quantitative models which will allow using mathematical tools and computational power to unravel the dynamic interactions of the molecules and cells in the heart during health and disease. The proposed interdisciplinary conference will closely combine experimental study and mathematical modeling iteratively to achieve quantitative in-depth understanding of the dynamic systems that control heart function and diseases. Through this conference, we intend to bring together internationally renowned experimentalists and modelers in the cardiac field to accomplishing the following goals. (1) Gain deeper understanding of the detailed dynamic interactions between the heart's electrical system, Ca2+ signaling system, and the muscle contractile system that work together to control the rhythm and the strength of heart beats. (2) Summarize the recent advancements in the cardiac E-C coupling field, Discuss the critical issue and controversies, and identify the most important questions for further research. (3) Facilitate exchange of the information and ideas among experimentalists and computational modelers in order to develop interdisciplinary collaborations.

NIH对会议和科学会议的支持(由申请人提供)：NIH对会议和科学会议的支持(A-0-01 Parent R13/U13)多名首席研究员：Donald M Bers，Phd，Ye Chen-Izu，Phd，Nipavan Chiamvimonvat MD和Leighton T Izu，药理学、生物医学工程、医学/心脏病学博士，加州大学戴维斯分校摘要心脏病，如心律失常和心力衰竭，是美国和发达国家成年人的头号杀手。为了开发更好、更有效的治疗方法来对抗心脏病，对疾病机制的更准确和更深入的了解至关重要。在最近几十年里，研究人员在分子、细胞和整个器官水平上取得了重要的概念进展，并积累了大量关于心脏内部工作的实验数据。现在重要的是加强将这些丰富的实验数据整合到定量模型中，这将允许使用数学工具和计算能力来揭示健康和疾病期间心脏中分子和细胞的动态相互作用。拟议的跨学科会议将以迭代的方式将实验研究和数学建模紧密结合，以实现对控制心脏功能和疾病的动态系统的定量深入了解。通过这次会议，我们打算将心脏领域的国际知名实验者和模型师聚集在一起，以实现以下目标。(1)深入了解心脏的电系统、钙信号系统和肌肉收缩系统之间的详细动态相互作用，这些系统共同控制心跳的节奏和强度。(2)综述了心脏E-C偶联研究的最新进展，讨论了关键问题和争议，并确定了进一步研究的最重要问题。(3)促进实验者和计算模型师之间的信息和想法的交流，以发展跨学科合作。