Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias

描述（由申请人提供）：NIH支持会议和科学会议（A-0-01家长R13/U13）理解心脏兴奋-收缩和心律失常的系统方法Donald M Bers, PhD, Ye Chen-Izu, PhD, Nipavan Chiamvimonvat， MD, and Leighton T Izu, PhD，药理学，生物医学工程，医学/心脏病学系[摘要]心律失常和心力衰竭等心脏病是美国和发达国家成年人的头号杀手。为了开发更好和更有效的治疗方法来对抗心脏病，获得更准确和更深入的疾病机制是至关重要的。近几十年来，研究人员在分子、细胞和整个器官水平上对心脏的内部工作取得了重要的概念进展，并积累了大量的实验数据。现在重要的是加强将这些丰富的实验数据整合到定量模型中，这将允许使用数学工具和计算能力来揭示健康和疾病期间心脏中分子和细胞的动态相互作用。本次跨学科会议将紧密结合实验研究和数学建模迭代，实现对控制心脏功能和疾病的动态系统的定量深入了解。通过这次会议，我们打算汇集国际知名的实验和建模在心脏领域，以实现以下目标。(1)更深入地了解心脏电系统、Ca2+信号系统和肌肉收缩系统之间的详细动态相互作用，它们共同控制心跳的节奏和强度。(2)总结心脏E-C耦合领域的最新进展，讨论关键问题和争议，并确定进一步研究的最重要问题。(3)促进实验者和计算建模者之间的信息和思想交流，以发展跨学科合作。

DESCRIPTION (provided by applicant): NIH Support for Conferences and Scientific Meetings (A-0-01 Parent R13/U13) Systems Approach to Understanding Cardiac Excitation-Contraction and Arrhythmias Multiple Principal Investigators: Donald M Bers, PhD, Ye Chen-Izu, PhD, Nipavan Chiamvimonvat, MD, and Leighton T Izu, PhD Departments of Pharmacology, Biomedical Engineering, Medicine/Cardiology, University of California Davis ABSTRACT Heart diseases such as arrhythmias and heart failure are the No.1 killer of the adult population in US and developed countries. To develop better and more effective therapies to combat heart diseases, it is critically important to gain more accurate and deeper understanding of the disease mechanisms. In the recent several decades, researchers have made important conceptual advances and accumulated large amounts of experimental data on the inner workings of the heart at molecular, cellular and whole organ levels. It is important now to enhance the integration of this rich experimental data into quantitative models which will allow using mathematical tools and computational power to unravel the dynamic interactions of the molecules and cells in the heart during health and disease. The proposed interdisciplinary conference will closely combine experimental study and mathematical modeling iteratively to achieve quantitative in-depth understanding of the dynamic systems that control heart function and diseases. Through this conference, we intend to bring together internationally renowned experimentalists and modelers in the cardiac field to accomplishing the following goals. (1) Gain deeper understanding of the detailed dynamic interactions between the heart's electrical system, Ca2+ signaling system, and the muscle contractile system that work together to control the rhythm and the strength of heart beats. (2) Summarize the recent advancements in the cardiac E-C coupling field, Discuss the critical issue and controversies, and identify the most important questions for further research. (3) Facilitate exchange of the information and ideas among experimentalists and computational modelers in order to develop interdisciplinary collaborations.