Systems Approach to Understanding Cardiac Arrhythmias Mechanisms
了解心律失常机制的系统方法
基本信息
- 批准号:9763307
- 负责人:
- 金额:$ 3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AreaArrhythmiaCardiacCause of DeathCell CommunicationClinicalCollaborationsCommunicationCommunitiesComplexComputer SimulationConsensusContractile SystemCouplingDataExperimental ModelsFeedbackFormulationGenerationsGoalsGrantHeartHeart DiseasesHispanicsHomeostasisInterdisciplinary StudyInternationalInvestigationIon ChannelJournalsKnowledgeLinkMathematicsMeasurementMechanicsMinorityModelingMolecularMyocardial dysfunctionNa(+)-K(+)-Exchanging ATPaseNatureNonlinear DynamicsOralOrganPaperParticipantPharmacotherapyPhysiciansPotassium ChannelPropertyPublicationsPublishingResearchResearch PersonnelRyanodine ReceptorsScientific EvaluationScientistSeriesSignal TransductionStudy modelsSystemTimeTissuesTreatment EfficacyWomanWorkdesigndynamic systemeffective therapyexperimental studyheart functioninsightinterdisciplinary collaborationknowledge integrationmathematical modelmechanotransductionnew therapeutic targetprogramssuccesssymposiumtoolweb site
项目摘要
ABSTRACT
Heart diseases are the No.1 cause of death in the US and developed world, but effective drug
therapies are still lacking. In order to develop better and more effective therapies to treat heart
diseases, it is critically important for physicians and scientists to gain accurate and in-depth
understanding of the cellular and molecular mechanisms of heart diseases. In recent decades,
researchers in the field have been accumulating more and more experimental data from
molecular, to cellular, and to tissue and organ levels. However, important conceptual advances
in the cardiac field require integration of the knowledge from multiple scales. Here we take the
necessary step forward to integrate experimental data into quantitative models that enable using
mathematical tools and computational power to understand the complex interactions of the cells
and molecules in the heart. The unique design of this conference series is to combine
experimental study and mathematical modeling to achieve in-depth understanding of the non-
linear dynamic systems that control cardiac function and heart diseases.
This conference is the 6th in our interdisciplinary symposium series entitled “System’s
Approach to Understand Cardiac Excitation-Contraction Coupling”. The previous 5 conferences
have received overwhelmingly positive evaluations from scientific community and resulted in
numerous high impact publications. This proposed conference will continue the uniquely
interdisciplinary format to combine experimental and modeling studies in the field of cardiac
arrhythmias. The topics will be focused on the cutting-edge research in cardiac excitation, Ca2+
signaling, contraction mechanics and mechanotransduction, with emphases on integrating the
the dynamic systems to gain a holistic and comprehensive understanding of heart diseases.
The goal of this conference will be focused on (1) summarizing current state of research in the
focus area, (2) identifying consensus and controversy that warrant more investigation, (3)
exchanging ideas, data, and information among the experimentalists and modelers to facilitate
interdisciplinary collaborations. The conference results will be summarized in the form of white
papers to be published in leading scientific journals that have broad impact in heart disease field.
摘要
心脏病是美国和发达国家的头号死因,但有效的药物
治疗仍然缺乏。为了开发更好更有效的治疗心脏病的方法,
对于医生和科学家来说,获得准确和深入的信息至关重要。
了解心脏病的细胞和分子机制。近几十年来,
该领域的研究人员已经积累了越来越多的实验数据,
分子、细胞、组织和器官水平。然而,重要的概念进展
在心脏领域需要从多个尺度的知识的集成。在这里,我们采取
将实验数据整合到定量模型中的必要步骤,
数学工具和计算能力来理解细胞的复杂相互作用
和心脏中的分子。本次会议系列的独特设计是将联合收割机
实验研究和数学建模,以实现深入了解非
控制心脏功能和心脏疾病的线性动态系统。
本次会议是我们的跨学科研讨会系列题为“系统的
理解心脏兴奋-收缩耦合的方法”。前5次会议
得到了科学界压倒性的积极评价,
许多影响力很大的出版物。本次会议将继续以独特的方式
联合收割机的跨学科形式,结合心脏领域的实验和建模研究
心律不齐主题将集中在心脏兴奋的前沿研究,Ca 2 +
信号,收缩机制和机械转导,重点是整合
动态系统,以获得对心脏病的整体和全面的了解。
本次会议的目标将集中在(1)总结研究现状,
重点领域,(2)确定需要更多调查的共识和争议,(3)
在实验者和建模者之间交换想法、数据和信息,
跨学科合作。会议成果将以白色形式汇总
在心脏病领域具有广泛影响力的领先科学期刊上发表的论文。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donald M Bers其他文献
The Difference of Calmodulin-Ryanodine Receptor Affinity Between N-terminal, Central and C-terminal RyR2-CPVT Knock-in Mice
N端、中央端和C端RyR2-CPVT敲入小鼠钙调蛋白-兰尼定受体亲和力的差异
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Hitoshi Uchinoumi;Xiaoqiong Dong;Ivanita Stefanon;Mena Said;Rogerio Faustino;Razvan L Cornea;Univ of Minnesota;Xander H.t. Wehrens; Takeshi Yamamoto;Masafumi Yano;Donald M Bers - 通讯作者:
Donald M Bers
Beyond beta blockers
超越β受体阻滞剂
- DOI:
10.1038/nm0405-379 - 发表时间:
2005-04-01 - 期刊:
- 影响因子:50.000
- 作者:
Donald M Bers - 通讯作者:
Donald M Bers
Donald M Bers的其他文献
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{{ truncateString('Donald M Bers', 18)}}的其他基金
Systems Approach to Understanding Cardiovascular Disease and Arrhythmias - Cell diversity in the cardiovascular system, cell-autonomous and cell-cell signaling
了解心血管疾病和心律失常的系统方法 - 心血管系统中的细胞多样性、细胞自主和细胞间信号传导
- 批准号:
10386681 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Modelling structural and functional heterogeneity in heart failure reveals arrhythmic impact
心力衰竭的结构和功能异质性建模揭示了心律失常的影响
- 批准号:
10199780 - 财政年份:2019
- 资助金额:
$ 3万 - 项目类别:
Modelling structural and functional heterogeneity in heart failure reveals arrhythmic impact
心力衰竭的结构和功能异质性建模揭示了心律失常的影响
- 批准号:
10449125 - 财政年份:2019
- 资助金额:
$ 3万 - 项目类别:
CaMKII activation and regulation in adult cardiac myocytes
成人心肌细胞中 CaMKII 的激活和调节
- 批准号:
10687251 - 财政年份:2018
- 资助金额:
$ 3万 - 项目类别:
High-Throughput Screens to Discover Novel Inhibitors of Leaky RyR2 for Heart Failure Therapy
高通量筛选发现用于心力衰竭治疗的漏性 RyR2 新型抑制剂
- 批准号:
10064096 - 财政年份:2018
- 资助金额:
$ 3万 - 项目类别:
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