Effects of Dietary Sodium and Potassium Intake on Subclinical and Clinical Cardio

膳食钠和钾摄入量对亚临床和临床心脏的影响

• 批准号: 8240478
• 负责人: Cheryl Ann Marie Anderson
• 金额: $ 5.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8240478
• 关键词: Advisory Committees; African American; Age; Antihypertensive Agents; Biomedical Research; Blood Pressure; Body Weight; Cardiovascular Diseases; Clinical; Clinical Research; Cohort Studies; Data Analyses; Data Collection; Development; Diet; Dietary Potassium; Dietary Sodium; Disease Outcome; Doctor of Philosophy; Elderly; Environment; Epidemiologist; Epidemiology; Excretory function; Faculty; Female; Funding; Gender; Goals; Health; Health behavior; Hour; Hypertension; Institution; Intake; International; K-Series Research Career Programs; Kidney Diseases; Left Ventricular Mass; Measures; Medical; Medicine; Mentors; Minority; National Heart, Lung, and Blood Institute; Nutritional; Obesity; Observational Study; Overweight; Patients; Population Study; Positioning Attribute; Potassium; Proxy; Public Health Schools; Research; Research Personnel; Scientist; Sodium; Source; Subgroup; Testing; Training; Underserved Population; United States National Institutes of Health; Universities; Weight; blood pressure regulation; cardiovascular disorder prevention; career; career development; cohort; interest; male; nutrition; prevent; professor; prospective; research and development; skills; urinary

This is Dr. Cheryl Anderson's application for a NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01). Cheryl Anderson, PhD, MPH is a nutritional epidemiologist and has a faculty position as an Assistant Scientist in the department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health (Hopkins). Dr. Anderson's research interests center around nutrition as a means to prevent cardiovascular disease (CVD) in minority and underserved populations. Her long-term goal is to combine her interdisciplinary training in health behavior, epidemiology and nutritional sciences to conduct observational and clinical studies of CVD. In this application, Dr. Anderson outlines a career development and research plan that provides critical new scientific skills and extend her research capabilities, to enhance her development into an independent scientist. Lawrence Appel, MD, MPH will mentor Dr. Anderson in the proposed research. Dr. Appel is a recognized expert in CVD prevention through both pharmacologic and non-pharmacologic (diet) approaches. He is a professor of medicine, epidemiology and international health (nutrition) at the Johns Hopkins Medical Institutions. Dr. Anderson has also assembled an advisory committee of accomplished researchers to provide scientific and career development advice, as well as evaluate her progress. The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass and clinical CVD. Her research will be conducted within the context of the NIH-funded African American Study of Kidney Disease and Hypertension (AASK) study. She will use do secondary analyses of data from both the AASK trial and AASK cohort study. The ongoing AASK cohort study is a prospective, observational study that is an extension of the AASK trial which tested the effects of three anti-hypertensive therapies and two levels of blood pressure control on progression of kidney disease. Dr. Anderson will also conduct additional (de-novo) data collection, in a subcohort of AASK, to characterize the sources of dietary sodium and potassium in the cohort - a highly relevant clinical issue. Dr. Anderson is in a supportive institutional environment at Hopkins that maximizes her potential to establish an independent, competitive research agenga that will support a prolific academic career.

这是谢丽尔·安德森（Cheryl Anderson）博士申请NHLBI指导职业发展奖，以促进 生物医学研究的教师多样性（K01）。 Cheryl Anderson博士，MPH是一名营养流行病学家 并在约翰·霍普金斯（Johns Hopkins）的流行病学系担任助理科学家的职位 彭博公共卫生学院（霍普金斯）。安德森博士的研究兴趣中心 营养作为预防少数民族和服务不足人群中心血管疾病（CVD）的一种手段。她 长期目标是结合她在健康行为，流行病学和营养方面的跨学科培训 进行CVD的观察和临床研究的科学。在此应用程序中，安德森博士概述了 职业发展和研究计划，提供关键的新科学技能并扩展她的研究 能力，将她的发展加入独立科学家。劳伦斯·阿佩尔（Lawrence Appel），医学博士，MPH 指导安德森博士在拟议的研究中。 Appel博士通过 药理学和非药物（饮食）方法。他是流行病学医学教授 约翰·霍普金斯医疗机构的国际健康（营养）。安德森博士也 组建了一个成熟研究人员的咨询委员会，以提供科学和职业发展 建议，并评估她的进度。安德森博士研究计划的目标是研究 饮食钠和钾摄入量的主要和交互作用（通过24小时排泄测量） 在超声心动图左心室（LV）质量和临床CVD上。她的研究将在 NIH资助的非裔美国人肾脏疾病和高血压研究（AASK）研究的背景。她 将使用来自AASK试验和AASK队列研究的数据进行辅助分析。正在进行的AASK 队列研究是一项前瞻性，观察性研究，是AASK试验的扩展，该试验测试了 三种抗高血压疗法和两个水平控制对肾脏进展的影响 疾病。安德森博士还将在ASK的子范围内进行其他（De-Novo）的数据收集 表征了队列中膳食钠和钾的来源 - 这是一个高度相关的临床问题。博士 安德森（Anderson）处于霍普金斯（Hopkins）的支持性机构环境中 独立的竞争性研究Agenga，将支持多产的学术生涯。