Effects of Dietary Sodium and Potassium Intake on Subclinical and Clinical Cardio

描述(由申请人提供)： 这是谢丽尔·安德森博士申请NHLBI导师职业发展奖，以促进生物医学研究中的教师多样性(K01)。谢丽尔·安德森博士，公共卫生硕士，营养流行病学家，约翰霍普金斯大学彭博公共卫生学院流行病学系助理科学家。安德森博士的研究兴趣集中在营养方面，以此作为在少数族裔和服务不足的人群中预防心血管疾病(CVD)的一种手段。她的长期目标是将她在健康行为、流行病学和营养科学方面的跨学科培训结合起来，进行心血管疾病的观察和临床研究。在这份申请中，安德森博士概述了一项职业发展和研究计划，该计划提供了关键的新科学技能，并扩展了她的研究能力，以促进她成为一名独立科学家。劳伦斯·阿佩尔，医学博士，公共卫生硕士，将在拟议的研究中指导安德森博士。阿佩尔博士是通过药理学和非药理学(饮食)方法预防心血管疾病的公认专家。他是约翰·霍普金斯医疗机构的医学、流行病学和国际卫生(营养学)教授。安德森博士还组建了一个由有成就的研究人员组成的顾问委员会，提供科学和职业发展建议，并评估她的进展。安德森博士的研究计划的目标是检验饮食钠和钾摄入量(通过24小时尿排泄量测量)对超声心动图左心室(LV)质量和临床心血管疾病的主要和交互影响。她的研究将在NIH资助的非裔美国人肾脏疾病和高血压研究(AASK)的背景下进行。她将对AASK试验和AASK队列研究的数据进行二次分析。正在进行的AASK队列研究是一项前瞻性的观察性研究，是AASK试验的扩展，该试验测试了三种抗高血压疗法和两种水平的血压控制对肾脏疾病进展的影响。安德森博士还将在AASK的一个子队列中进行额外的(从头开始)数据收集，以确定队列中饮食中钠和钾的来源--这是一个高度相关的临床问题。安德森博士目前在霍普金斯大学处于支持性的机构环境中，她最大限度地发挥了潜力，建立了一个独立、有竞争力的研究机构，为多产的学术生涯提供支持。(摘要结束)

DESCRIPTION (provided by applicant): This is Dr. Cheryl Anderson's application for a NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01). Cheryl Anderson, PhD, MPH is a nutritional epidemiologist and has a faculty position as an Assistant Scientist in the department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health (Hopkins). Dr. Anderson's research interests center around nutrition as a means to prevent cardiovascular disease (CVD) in minority and underserved populations. Her long-term goal is to combine her interdisciplinary training in health behavior, epidemiology and nutritional sciences to conduct observational and clinical studies of CVD. In this application, Dr. Anderson outlines a career development and research plan that provides critical new scientific skills and extend her research capabilities, to enhance her development into an independent scientist. Lawrence Appel, MD, MPH will mentor Dr. Anderson in the proposed research. Dr. Appel is a recognized expert in CVD prevention through both pharmacologic and non-pharmacologic (diet) approaches. He is a professor of medicine, epidemiology and international health (nutrition) at the Johns Hopkins Medical Institutions. Dr. Anderson has also assembled an advisory committee of accomplished researchers to provide scientific and career development advice, as well as evaluate her progress. The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass and clinical CVD. Her research will be conducted within the context of the NIH-funded African American Study of Kidney Disease and Hypertension (AASK) study. She will use do secondary analyses of data from both the AASK trial and AASK cohort study. The ongoing AASK cohort study is a prospective, observational study that is an extension of the AASK trial which tested the effects of three anti-hypertensive therapies and two levels of blood pressure control on progression of kidney disease. Dr. Anderson will also conduct additional (de-novo) data collection, in a subcohort of AASK, to characterize the sources of dietary sodium and potassium in the cohort - a highly relevant clinical issue. Dr. Anderson is in a supportive institutional environment at Hopkins that maximizes her potential to establish an independent, competitive research agenga that will support a prolific academic career. (End of Abstract)