Ovarian Cancer: Prevention of the Disease and Its Recurrence

描述(申请人提供)：卵巢癌是美国妇科恶性肿瘤最常见的死亡原因，2010年导致13,850人死亡。大多数女性在确诊时都患有晚期疾病。尽管进行了积极的治疗，但这些妇女的预后很差：5年存活率不到30%。这一糟糕的结果是由于缺乏有效的预防和早期发现战略：在早期阶段被诊断时，存活率为85%-90%。因此，预防和及早发现是战胜这种疾病的关键。然而，几乎没有预防方法，而且目前的筛查技术未能降低发病率或死亡率。因此，我们迫切需要确定更好的预防、检测和筛查方法。此外，由于这种疾病的毒性和通常是致命的，大多数患有卵巢癌的女性生活在对复发的恐惧中，这种情况发生在大约85%的病例中。目前的治疗方法希望渺茫，预防复发的研究也很有限。迫切需要新的方法来预防、检测和治疗复发。利用NCI在2002和2005年的资助，我们举办了关于卵巢癌的研讨会，汇聚了世界各地来自不同科学学科的预防卵巢癌及其复发的专家。这些会议取得的成功和产生的热情突出表明，有必要定期举行会议，重点讨论卵巢癌问题。不存在其他这种类型的会议。我们建议每两年举办一次研讨会，以促进来自不同学科的科学家、政策制定者和消费者权益倡导者之间的互动，以便在战胜这种疾病方面取得进展。研讨会系列的具体目的是扩大我们对卵巢癌潜在机制的了解和研究，重点是将这些知识应用于预防和早期发现疾病及其复发。NCI已将分子和生物机制、高通量技术、遗传学和靶向治疗作为2011财年的主要目标，卵巢癌是重点领域。最近的科学和技术进步，加上缺乏专门针对卵巢癌的定期科学会议，支持需要举行一系列专题讨论会，讨论研究卵巢癌的创新方法。 公共卫生相关性：卵巢癌是女性妇科癌症的头号杀手。在克服这种疾病方面进展甚微。没有以卵巢癌研究为重点的定期科学会议。一个小型的、重点明确的会议，以促进来自不同学科的卵巢癌专家之间的相互交谈，而这些专家通常不会或一直没有互动，这是在克服这一杀手方面取得进展的关键一步。

DESCRIPTION (provided by applicant): Ovarian cancer is the most common cause of death from gynecologic malignancy in the US, resulting in 13,850 deaths in 2010. Most women have advanced disease at diagnosis. Despite aggressive treatment, prognosis for these women is poor: 5-year survival is less than 30%. This poor outcome is due to the lack of effective prevention and early detection strategies: when diagnosed at an early stage, the survival rate is 85-90%. Thus, prevention and early detection are key to overcoming this disease. However, few preventive modalities exist and current screening techniques have failed to reduce morbidity or mortality. Thus, we urgently need to identify better prevention, detection and screening methods. Moreover, because of the virulent and usually fatal nature of the disease, most women with ovarian cancer live with fear of recurrence, which happens in ~85% of cases. Current treatments offer little hope, and research into preventing recurrence is limited. New methods to prevent, detect and treat recurrence are urgently needed. With NCI funding in 2002 & 2005, we hosted symposia on ovarian cancer, bringing together the world's experts on prevention of the disease and its recurrence from various scientific disciplines. The success and enthusiasm generated by those meetings underscore the need for periodic meetings focused on ovarian cancer. No other meetings of this type exist. We propose to organize biennial symposia to facilitate interactions among scientists from different disciplines, policy makers and consumer advocates so that progress can be made in overcoming this disease. The Specific Aim of the symposia series is to expand our understanding of and research in the underlying mechanisms in ovarian cancer, with a focus on applying that knowledge to prevention and early detection of the diseases and its recurrence. The NCI has made molecular and biologic mechanisms, high-throughput technologies, genetics, and targeted therapies key goals in FY2011, with ovarian cancer a focus area. Recent scientific and technological advances, together with the lack of periodic scientific meetings specifically on ovarian cancer, support the need for a series of symposia on innovative approaches to research in ovarian cancer. PUBLIC HEALTH RELEVANCE: Ovarian cancer is the leading killer among gynecologic cancers in women. Little progress has been made in overcoming this disease. There is no periodic scientific meeting focused on ovarian cancer research. A small, well-focused meeting to facilitate cross-talk among ovarian cancer experts from various disciplines who do not typically or consistently interact is a key step in making progress in overcoming this killer.