Patient Oriented Research in Kidney Disease

描述（由申请人提供）：徐志远，医学博士，理学硕士，现申请“患者导向研究中期研究者奖”（K24），以加强他的原创研究和指导工作。这项新研究利用了徐博士正在进行的资助项目，并代表了他之前工作的主题扩展。它还旨在为学员提供培训机会。潜在的主题是在几个方面推进对肾功能急性恶化的意义和性质的理解。具体目的是：目的1：确定总体和临床重要亚组中急性肾功能衰竭(ARF)/急性肾损伤（AKI）的人群发生率，并确定其背后的潜在驱动力。目的2：确定肾功能突然丧失作为直接从慢性肾脏疾病（CKD）到终末期肾脏疾病（ESRD）的途径的重要性。目的3：确定急性心力衰竭的急性肾功能恶化与肾小管损伤标志物水平升高的关联程度。许博士之前有很强的指导记录，并在加州大学旧金山分校丰富、支持和学院的制度环境中工作。K24奖的资助将允许许博士花更少的时间在行政和临床责任上，更多的时间在研究和指导上。

DESCRIPTION (provided by applicant): Chi-yuan Hsu, MD, MSc is applying for a Mid-career Investigator Award in Patient Oriented Research (K24) in order to augment his original research and mentorship efforts. The new research to be supported by this grant leverages Dr. Hsu's ongoing funded projects and represents thematic expansions of his prior work. It is also designed to provide training opportunities for mentees. The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts. The specific aims are: Aim 1: To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this. Aim 2: To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Aim 3: To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury. Dr. Hsu has a strong prior track record of mentorship and works within the rich, supportive and collegial institutional environment at UCSF. Funding from this K24 award will permit Dr. Hsu to spend less time on administrative and clinical responsibilities and more time on research and mentoring.