(1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center

项目总结 (1/1)通过北加州阿波罗网络最大限度地扩大地理和科学覆盖范围： 申请临床中心 我们是根据RFA-DK-16-025的要求提交这份申请的。我们建议北加州的阿波罗 总部设在加州大学旧金山分校(UCSF；全球最繁忙的肾脏移植中心 国家)、加州大学戴维斯分校(UC Davis)、加州太平洋医学中心(CPMC)和斯坦福大学 大学。我们与器官采购组织协会(AOPO)建立了合作关系， 器官共享联合网络(UNOS)和移植受者科学登记处(SRTR)。我们 还与美国西部的另外16个移植中心建立了关系(在 夏威夷、华盛顿、俄勒冈州、内华达州、犹他州、亚利桑那州、新墨西哥州和南加州)，他们表达了 有兴趣与我们合作和合作。我们相信我们的北加州阿波罗网络将 对财团更好地界定APOL1之间的关系的总体目标作出重要贡献 肾移植受者和捐赠者的风险状况和结局。我们将加入其他临床中心 并从所有非裔美国人肾脏捐赠者和 在美国各地接受这些肾脏的人，在基线和纵向上，并传输这些数据 和样本送往科学和数据研究中心(SDRC)。我们的应用程序的一些优点 (“本网站独有的要素”)包括：一)包括几个大容量的肾移植中心；二)覆盖范围 广泛、毗连的地理区域；iii)具有丰富经验的多学科研究团队 肾脏疾病和多中心联合体的前瞻性队列研究；iv)具有成本效益的“混合”模型研究 设计-联合分析作为研究方案一部分收集的数据和作为研究方案一部分收集的数据 临床护理(或登记)--这将大大增加人-年的跟踪和 加强研究能力；v)加强网络内现有的肾脏移植研究基础设施，包括 加州大学旧金山分校正在进行的同种异体移植活检样本(以及同时进行的血液和尿液样本)的生物库， 这将提供与APOL1高危状态相关的肾脏病理的有价值的信息。

PROJECT SUMMARY (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center We submit this application in response to RFA-DK-16-025. We propose a Northern California APOLLO Network based at University of California San Francisco (UCSF; the busiest kidney transplant center in the country), University of California Davis (UC Davis), California Pacific Medical Center (CPMC) and Stanford University. We have secured collaborations with the Association of Organ Procurement Organizations (AOPO), United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipients (SRTR). We have also established relationships with 16 additional transplant centers in the western United States (in Hawaii, Washington, Oregon, Nevada, Utah, Arizona, New Mexico, and Southern California) who expressed interest in collaborating and partnering with us. We believe that our Northern California APOLLO Network will contribute importantly to the overall goal of the Consortium to better define the relationship between APOL1 risk status and outcomes among kidney transplant recipients and donors. We will join other Clinical Centers and obtain biological samples, genetic and clinical information from all African American kidney donors and the recipients of those kidneys across the United States, at baseline and longitudinally, and transmit those data and samples to the Scientific and Data Research Center (SDRC). Some strengths of our application (”Elements Unique to This Site”) are: i) inclusion of several high-volume kidney transplant centers; ii) coverage of a wide, contiguous geographic region; iii) multi-disciplinary research team with extensive experience in prospective cohort studies of kidney disease and multi-center consortia; iv) cost-effective “hybrid” model study design—jointly analyzing data collected as part of a research protocol together with data collected as part of clinical care (or entered into a registry)—that will greatly increase the number of person-years of follow-up and enhance study power; v) strong existing kidney transplant research infrastructure within the network, including ongoing bio-banking at UCSF of protocol allograft biopsy samples (and concurrent blood and urine samples), which will provide valuable information regarding renal pathology associated with APOL1 high-risk status.