(1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center

项目摘要 （1/1）通过北方加州阿波罗网络最大限度地扩大地理和科学覆盖范围： 临床中心申请 我们根据RFA-DK-16-025提交本申请。我们建议北方加州阿波罗 位于加州旧金山弗朗西斯科（UCSF;美国最繁忙的肾移植中心）的网络 国家）、加州戴维斯大学（UC Davis）、加州太平洋医学中心（CPMC）和斯坦福大学 大学我们与器官采购组织协会（AOPO）合作， 器官共享联合网络（UNOS）和移植接受者科学登记处（SRTR）。我们 还与美国西部的另外16个移植中心建立了关系（ 夏威夷、华盛顿、俄勒冈州、内华达州、犹他州、亚利桑那州、新墨西哥州和南加州）， 有兴趣与我们合作。我们相信，我们的北方加州阿波罗网络将 对联盟的总体目标做出重要贡献，以更好地定义APOL 1之间的关系， 肾移植受者和捐赠者的风险状况和结果。我们将加入其他临床中心 并从所有非裔美国人肾脏捐赠者和非裔美国人肾脏捐赠者那里获得生物样本、遗传和临床信息。 这些肾脏的接受者在美国各地，在基线和纵向，并传输这些数据， 科学和数据研究中心（SDRC）。我们的应用程序的一些优势 （“本网站的独特元素”）是：i）包括几个大容量肾移植中心; ii）覆盖范围 三）具有丰富经验的多学科研究团队， 肾脏疾病的前瞻性队列研究和多中心联合研究; iv）成本效益“混合”模型研究 设计-联合分析作为研究方案的一部分收集的数据以及作为 临床护理（或进入登记）-这将大大增加随访的人年数， 增强研究能力; v）网络内现有的强大的肾移植研究基础设施，包括 正在UCSF进行方案同种异体移植物活检样本（以及同期血液和尿液样本）的生物库， 其将提供关于与APOL 1高风险状态相关的肾脏病理学的有价值的信息。

PROJECT SUMMARY (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center We submit this application in response to RFA-DK-16-025. We propose a Northern California APOLLO Network based at University of California San Francisco (UCSF; the busiest kidney transplant center in the country), University of California Davis (UC Davis), California Pacific Medical Center (CPMC) and Stanford University. We have secured collaborations with the Association of Organ Procurement Organizations (AOPO), United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipients (SRTR). We have also established relationships with 16 additional transplant centers in the western United States (in Hawaii, Washington, Oregon, Nevada, Utah, Arizona, New Mexico, and Southern California) who expressed interest in collaborating and partnering with us. We believe that our Northern California APOLLO Network will contribute importantly to the overall goal of the Consortium to better define the relationship between APOL1 risk status and outcomes among kidney transplant recipients and donors. We will join other Clinical Centers and obtain biological samples, genetic and clinical information from all African American kidney donors and the recipients of those kidneys across the United States, at baseline and longitudinally, and transmit those data and samples to the Scientific and Data Research Center (SDRC). Some strengths of our application (”Elements Unique to This Site”) are: i) inclusion of several high-volume kidney transplant centers; ii) coverage of a wide, contiguous geographic region; iii) multi-disciplinary research team with extensive experience in prospective cohort studies of kidney disease and multi-center consortia; iv) cost-effective “hybrid” model study design—jointly analyzing data collected as part of a research protocol together with data collected as part of clinical care (or entered into a registry)—that will greatly increase the number of person-years of follow-up and enhance study power; v) strong existing kidney transplant research infrastructure within the network, including ongoing bio-banking at UCSF of protocol allograft biopsy samples (and concurrent blood and urine samples), which will provide valuable information regarding renal pathology associated with APOL1 high-risk status.