(1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center

(1/1) 通过北加州 APOLLO 网络最大化地理和科学影响力：申请临床中心

• 批准号: 10675980
• 负责人: Chi-yuan Hsu
• 金额: $ 12.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675980
• 关键词: African American; African American population; Alleles; Allografting; American; Apolipoproteins; Area; Arizona; Base Pairing; Bioethics; Biological; Biometry; Biopsy Specimen; Black American; Blood; California; Chronic Kidney Failure; Clinical; Collaborations; Country; Data; Data Analyses; Donor person; Elements; End stage renal failure; Enrollment; Epidemiology; Ethnic Origin; European; Evaluation; Failure; Genes; Genetic; Genetic Polymorphism; Genotype; Geographic Locations; Geography; Goals; Habits; Hawaii; Health; Hybrids; Interdisciplinary Study; Kidney; Kidney Diseases; Kidney Transplantation; Knowledge; Living Donors; Longitudinal Studies; Medical center; Network-based; Nevada; New Mexico; Oregon; Organ Procurements; Outcome; Pathology; Persons; Prospective Studies; Prospective cohort study; Protocols documentation; Race; Registries; Renal function; Research; Research Design; Research Infrastructure; Risk; Sampling; San Francisco; Secure; Site; Socioeconomic Status; Study models; Transplant Recipients; Transplantation; United Network for Organ Sharing; United States; Universities; Urine; Utah; Variant; Washington; Work; clinical application; clinical care; clinical center; comorbidity; cost effective; epidemiology study; experience; follow-up; high risk; improved; indexing; interest; living kidney donor; novel; organ allocation; racial difference; rate of change; response; risk variant; screening; transplant centers; transplant registry

PROJECT SUMMARY (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center We submit this application in response to RFA-DK-16-025. We propose a Northern California APOLLO Network based at University of California San Francisco (UCSF; the busiest kidney transplant center in the country), University of California Davis (UC Davis), California Pacific Medical Center (CPMC) and Stanford University. We have secured collaborations with the Association of Organ Procurement Organizations (AOPO), United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipients (SRTR). We have also established relationships with 16 additional transplant centers in the western United States (in Hawaii, Washington, Oregon, Nevada, Utah, Arizona, New Mexico, and Southern California) who expressed interest in collaborating and partnering with us. We believe that our Northern California APOLLO Network will contribute importantly to the overall goal of the Consortium to better define the relationship between APOL1 risk status and outcomes among kidney transplant recipients and donors. We will join other Clinical Centers and obtain biological samples, genetic and clinical information from all African American kidney donors and the recipients of those kidneys across the United States, at baseline and longitudinally, and transmit those data and samples to the Scientific and Data Research Center (SDRC). Some strengths of our application (”Elements Unique to This Site”) are: i) inclusion of several high-volume kidney transplant centers; ii) coverage of a wide, contiguous geographic region; iii) multi-disciplinary research team with extensive experience in prospective cohort studies of kidney disease and multi-center consortia; iv) cost-effective “hybrid” model study design—jointly analyzing data collected as part of a research protocol together with data collected as part of clinical care (or entered into a registry)—that will greatly increase the number of person-years of follow-up and enhance study power; v) strong existing kidney transplant research infrastructure within the network, including ongoing bio-banking at UCSF of protocol allograft biopsy samples (and concurrent blood and urine samples), which will provide valuable information regarding renal pathology associated with APOL1 high-risk status.

项目摘要 （1/1）通过北加州阿波罗网络最大化地理和科学范围： 临床中心申请 我们根据RFA-DK-16-025提交此申请。我们建议北加州阿波罗 位于加州大学旧金山分校的网络（UCSF；最繁忙的肾脏移植中心 国家 /地区，加利福尼亚大学戴维斯分校（加州大学戴维斯分校），加利福尼亚太平洋医疗中心（CPMC）和斯坦福大学 大学。我们已经与器官采购组织协会（AOPO）合作， 联合器官共享网络（UNOS）和移植接受者的科学注册表（SRTR）。我们 还在美国西部建立了与另外16个移植中心建立关系（in 夏威夷，华盛顿，俄勒冈州，内华达州，犹他州，亚利桑那州，新墨西哥州和南加州） 对与我们合作和合作的兴趣。我们相信我们的北加州阿波罗网络将 重要的是为财团的整体目标做出贡献，以更好地定义APOL1之间的关系 肾脏移植者和捐助者的风险状况和结果。我们将加入其他临床中心 并从所有非裔美国人肾脏供体获得生物样品，遗传和临床信息以及 在基线和纵向时，这些孩子的那些孩子的接收者，并传输这些数据 并将样品转到科学与数据研究中心（SDRC）。我们应用的一些优势 （“本网站独有的元素”）是：i）包括几个大容量肾脏移植中心； ii）覆盖范围 一个宽阔的连续地理区域； iii）具有丰富经验的多学科研究团队 肾脏疾病和多中心财团的前瞻性队列研究； iv）具有成本效益的“混合”模型研究 设计 - 作为研究协议的一部分收集的数据，以及收集的数据，作为一部分 临床护理（或进入注册表） - 将大大增加随访的人数和 增强研究能力； v）网络中强大的现有肾脏移植研究基础设施，包括 同种异体移植活检样本（以及并发的血液和尿液样本）的UCSF的持续生物银行， 它将提供有关与APOL1高风险状况相关的肾脏病理学的宝贵信息。