Isoform-specific roles of the histone variant macroH2A1 in memory and Alzheimer's disease

组蛋白变体 MacroH2A1 在记忆和阿尔茨海默病中的异构体特异性作用

• 批准号: 472567
• 负责人: Zovkic Iva
• 金额: $ 7.29万
• 依托单位: University of Toronto Mississauga (ON)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=472567&lang=en
• 关键词: Alzheimer'S Disease; Chromatin; Epigenetics; Gene Expression; Histone Variants; Macroh2a1; Memory; Mice

Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive memory decline. We recently identified histone variants as novel epigenetic regulators of memory that are promising therapeutic targets for memory deficits.

阿尔茨海默病(AD)是一种以进行性记忆衰退为特征的衰弱神经退行性疾病。我们最近发现组蛋白变体是一种新的记忆表观遗传调节剂，有望成为治疗记忆缺陷的靶点。