Electrophysiological and psychophysical measures of auditory temporal processing

听觉时间处理的电生理学和心理物理学测量

• 批准号: 8316802
• 负责人: Sara K. Mamo
• 金额: $ 5.91万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-09 至 2015-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8316802
• 关键词: Acoustics; Address; Affect; Age; Age-associated memory impairment; Aging; Aging-Related Process; Auditory; Auditory Brainstem Responses; Auditory system; Brain Stem; Burn injury; Characteristics; Clinical; Clinical assessments; Code; Cognitive; Complement; Complex; Cueing for speech; Cues; Data Analyses; Detection; Ear; Elderly; Evaluation; Evoked Potentials; Evoked Potentials, Auditory, Brain Stem; Exhibits; Frequencies; Generations; Goals; Hearing; Investigation; Knowledge; Masks; Measures; Mentorship; Methods; Modeling; Noise; Pattern; Performance; Periodicity; Phase; Population; Process; Psychophysiology; Research; Research Design; Sensory; Signal Transduction; Simulate; Speech; Speech Perception; Speech Sound; Stimulus; Testing; Training Programs; Translating; age related; aging population; base; clinically relevant; cognitive change; computerized data processing; design; experience; improved; indexing; interest; relating to nervous system; research study; response; sound; speech processing; tool; young adult

DESCRIPTION (provided by applicant): The long-term aim of this project is to determine the relationship between temporal processing deficits apparent in the brainstem response to complex acoustic cues and speech perception difficulties in noisy backgrounds. The specific objective of the proposed research is to characterize the brainstem encoding of speech and other complex stimuli in young and older adults. The proposed experiments are designed to compare younger and older listeners with near-normal audiometric hearing in order to understand how reduced fidelity of temporal processing affects encoding of the temporal components of speech and, consequently, speech perception. Aim 1 will employ auditory brainstem response measures elicited by speech as an index of periodicity coding. This study will test the primary hypothesis that the degree of periodicity coding measured at the level of the brainstem is dependent on stimulus duration. Aim 2 will model temporal deficits exhibited in the aging auditory system by estimating a measure of 'internal noise' for the older adults. This study will rely on an evaluation of the brainstem response elicited by speech stimuli that has been corrupted using a temporal jitter model. Aim 3 will relate the electrophysiological measures to psychophysical and speech perception measures in young and older adults. Both the psychophysical task (detection of dichotic low-rate frequency modulation) and the speech task (modulation masking release) are designed to capture aspects of temporal processing. The training program involves strong mentorship in research design, especially in the domain of signal processing (stimulus generation, response analysis, etc.) and data analysis essential to the proposed research. Results will contribute to a more refined understanding of sub-cortical processing of speech sounds and the effects of temporal processing deficits on speech processing. The translational emphasis of this project is to optimize the use of complex-ABR measures for the assessment of clinical populations who experience difficulty perceiving speech despite audiometrically normal hearing. PUBLIC HEALTH RELEVANCE: Speech-evoked auditory brainstem responses have been used to investigate auditory processing in a variety of clinical populations. This project will advance our understanding of how these responses depend on the characteristics of the speech sound as well as on the integrity of temporal processing in the affected ear. Project results will have direct clinical relevance in terms of the use of speech-evoked auditory brainstem responses in the assessment of populations with speech perception difficulties.

描述（由申请人提供）：本项目的长期目标是确定脑干对复杂声学线索的反应中明显的时间处理缺陷与噪声背景中的言语感知困难之间的关系。拟议研究的具体目标是描述年轻人和老年人的脑干编码语音和其他复杂刺激。拟议的实验旨在比较年轻和年长的听众与接近正常的听力，以了解如何减少保真度的时间处理影响编码的时间组成部分的语音，因此，语音感知。目标1将采用听觉脑干反应措施引起的讲话作为一个指标的周期性编码。本研究将测试的主要假设，即程度的周期性编码测量的水平， 脑干依赖于刺激持续时间。目标2将通过估计老年人的“内部噪声”来模拟老化听觉系统中表现出的时间缺陷。这项研究将依赖于评价的脑干反应引起的言语刺激，已被损坏，使用时间抖动模型。目标3将涉及年轻人和老年人的电生理措施，心理物理和言语感知措施。这两个心理物理任务（检测双耳分音低速率频率调制）和语音任务（调制掩蔽释放）的目的是捕捉方面的时间处理。培训计划涉及研究设计方面的强有力的指导，特别是在信号处理领域（刺激生成，响应分析等）。数据分析是研究所必需的。研究结果将有助于更好地理解皮层下语音处理和语音处理的时间处理缺陷的影响。该项目的翻译重点是优化复杂ABR措施的使用，用于评估尽管听力正常但难以感知语音的临床人群。 公共卫生关系：言语诱发的听觉脑干反应已被用于研究各种临床人群的听觉处理。这个项目将促进我们的理解，这些反应如何取决于语音的特点，以及在受影响的耳朵的时间处理的完整性。项目结果将在使用言语诱发听觉脑干反应评估言语感知困难人群方面具有直接的临床相关性。