Electrophysiological and psychophysical measures of auditory temporal processing

听觉时间处理的电生理学和心理物理学测量

• 批准号: 8403418
• 负责人: Sara K. Mamo
• 金额: $ 6.09万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-09 至 2015-01-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403418
• 关键词: Acoustics; Address; Affect; Age; Age-associated memory impairment; Aging; Aging-Related Process; Auditory; Auditory Brainstem Responses; Auditory system; Brain Stem; Burn injury; Characteristics; Clinical; Clinical assessments; Code; Cognitive; Complement; Complex; Cueing for speech; Cues; Data Analyses; Detection; Ear; Elderly; Evaluation; Evoked Potentials; Evoked Potentials, Auditory, Brain Stem; Exhibits; Frequencies; Generations; Goals; Hearing; Investigation; Knowledge; Masks; Measures; Mentorship; Methods; Modeling; Noise; Pattern; Performance; Periodicity; Phase; Population; Process; Psychophysics; Research; Research Design; Sensory; Signal Transduction; Simulate; Speech; Speech Perception; Speech Sound; Stimulus; Testing; Training Programs; Translating; age related; aging population; base; clinically relevant; cognitive change; computerized data processing; design; experience; improved; indexing; interest; relating to nervous system; research study; response; sound; speech processing; tool; young adult

DESCRIPTION (provided by applicant): The long-term aim of this project is to determine the relationship between temporal processing deficits apparent in the brainstem response to complex acoustic cues and speech perception difficulties in noisy backgrounds. The specific objective of the proposed research is to characterize the brainstem encoding of speech and other complex stimuli in young and older adults. The proposed experiments are designed to compare younger and older listeners with near-normal audiometric hearing in order to understand how reduced fidelity of temporal processing affects encoding of the temporal components of speech and, consequently, speech perception. Aim 1 will employ auditory brainstem response measures elicited by speech as an index of periodicity coding. This study will test the primary hypothesis that the degree of periodicity coding measured at the level of the brainstem is dependent on stimulus duration. Aim 2 will model temporal deficits exhibited in the aging auditory system by estimating a measure of 'internal noise' for the older adults. This study will rely on an evaluation of the brainstem response elicited by speech stimuli that has been corrupted using a temporal jitter model. Aim 3 will relate the electrophysiological measures to psychophysical and speech perception measures in young and older adults. Both the psychophysical task (detection of dichotic low-rate frequency modulation) and the speech task (modulation masking release) are designed to capture aspects of temporal processing. The training program involves strong mentorship in research design, especially in the domain of signal processing (stimulus generation, response analysis, etc.) and data analysis essential to the proposed research. Results will contribute to a more refined understanding of sub-cortical processing of speech sounds and the effects of temporal processing deficits on speech processing. The translational emphasis of this project is to optimize the use of complex-ABR measures for the assessment of clinical populations who experience difficulty perceiving speech despite audiometrically normal hearing.

描述(由申请人提供)：本项目的长期目标是确定脑干对复杂声学提示的反应中明显的时间处理缺陷与嘈杂背景下的言语感知困难之间的关系。这项拟议的研究的具体目标是描述年轻人和老年人对语音和其他复杂刺激的脑干编码。这些实验旨在比较年轻和年长的听者和接近正常听力的人，以了解时间处理的保真度降低如何影响语音的时间成分编码，从而影响语音感知。目标1将使用语音诱发的听觉脑干反应作为周期性编码的指标。这项研究将检验主要假设，即在编码水平上测量的周期性编码程度 脑干取决于刺激持续时间。Aim 2将通过估计老年人的“内部噪音”来模拟老化的听觉系统中表现出的时间缺陷。这项研究将依赖于使用时间抖动模型对被破坏的语音刺激引起的脑干反应的评估。目标3将在年轻人和老年人中将电生理测量与心理物理和言语感知测量联系起来。心理物理任务(检测二分低速率频率调制)和语音任务(调制掩蔽释放)都被设计来捕捉时间处理的各个方面。培训计划包括在研究设计方面的强大指导，特别是在信号处理领域(刺激产生、反应分析等)。以及对拟议研究至关重要的数据分析。这些结果将有助于更好地理解语音的皮层下加工以及时间加工缺陷对语音加工的影响。该项目的翻译重点是优化复杂ABR测量的使用，以评估尽管听力测试正常但仍有语言感知困难的临床人群。