L1 逆转录转座子和神经多样性-猫眼课题宝

L1 逆转录转座子和神经多样性

批准号：

8259842

负责人：

FRED H GAGE

金额：

$37.5万

依托单位：

SALK INSTITUTE FOR BIOLOGICAL STUDIES

依托单位国家：

美国

项目类别：

财政年份：

2009

资助国家：

美国

项目状态：

已结题

起止时间：

2009-08-12 至 2013-10-30

来源：

https://reporter.nih.gov/project-details/8259842

关键词：

Africa Age Attenuated Behavior Biological Brain Cell Proliferation Cell physiology Climate Cognition Cognitive Complex Computer Simulation DNA Transposable Elements Data Reporting Elements Embryonic Development Environment Enzymes Epigenetic Process Event Evolution Family Fossils Future Generations Gene Expression Genes Genetic Genetic Transcription Genome Genomics Germ Germ Cells Goals Hominidae Human Human Genome Ice Indium Individual Inherited Introns Junk DNA L1 Elements Language Life Link Literature Location Mammals Maps Mitochondria Mobile Genetic Elements Modeling Modification Molecular Monozygotic twins Mus Nervous system structure Neurologic Neurons Organ Organism Outcome Study Pan Genus Parasites Partner in relationship Phenotype Phylogeny Plastics Population Process Public Health RNA-Directed DNA Polymerase Recording of previous events Regulator Genes Resources Retroelements Retrotransposition Retrotransposon Scientist Secure Selfish DNA Social Behavior Somatic Cell System Terminology Testing Testis Brain Tissues Transcript Variant abstracting base blastomere structure body system brain cell climate change cost environmental change epigenetic variation fitness insight mammalian genome meetings mouse model nervous system disorder next generation non-genetic precursor cell relating to nervous system social theories tool trait transmission process

项目摘要

项目成果

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中文摘要

翻译

项目总结/摘要 LINE-1（L1）反转录转座子是基因组中的活性元件，能够在神经元前体细胞中动员，导致大脑中的嵌合体。在动员时，L1插入可以改变基因表达，导致神经元的遗传异质性群体。该提案的第一个目的是确定L1基因组位点在人脑中相比，从同一个人的体细胞组织，以映射和表征从头插入在大脑中。第二个目的是在小鼠模型中减弱L1反转录转位，从而研究L1在行为中的功能意义。

英文摘要

Project Summary/Abstract LINE-1 (L1) retrotransposons are active elements in the genome capable of mobilization in neuronal precursor cells, resulting in a mosaic in the brain. Upon mobilization, L1 insertions can alter gene expression, resulting in a genetic heterogenic population of neurons. The first aim of this proposal is to identify genomic loci of L1s in the human brain as compared to somatic tissues from the same individual in order to map and characterize de novo insertions in the brain. The second aim is to attenuate L1 retrotransposition in a mouse model and thereby investigate the functional significance of L1 in behavior.

期刊论文(4)

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科研奖励(0)

会议论文

L1 retrotransposition in neurons is modulated by MeCP2.

DOI： 10.1038/nature09544

发表时间： 2010-11-18

期刊：

Nature

影响因子： 64.8

作者：

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