Neuromedical Core (Page 348)

抗逆转录病毒治疗的进展减少了死亡率和神经系统发病率，但并未消除 与艾滋病毒感染有关。这种流行病已经演变成一种慢性病，在这种疾病中有一种 维持病毒持久性的机制和宿主免疫策略之间的动态平衡， 结合抗逆转录病毒治疗，控制病毒活动。根除或治愈的前景是 许多年或几十年后。展望未来，HNRC认为有四个主要领域 研究需求是最大的。在更新期，神经医学核心(NMC)将因此而发展 并成熟其研究基础设施，以支持针对老龄化、急性和早期主题的研究 HIV感染与临床相关性。连接这三个主题的一个共同线索是遗传学--两者都是 而且像病毒一样传播。 新组建的NMC由两个合作单位组成，这些单位拥有共同的资源 (设备、用品)和日常互动的工作人员：临床研究支助股；以及 实验室、药理学和生物标记单位(LPBU)。这些单位将共同对所有 艾滋病毒受试者和艾滋病毒控制，包括参加发展核心试点研究的人。这个 神经医学核心(NMC)的总体目标是提供全面的临床和 实验室评估、科学咨询以及指导、培训和社区教育 神经艾滋病。在目前的供资期间，国家MC促进了70个研究项目，其中包括观察性项目 队列研究、临床病理调查、影像研究、临床试验和国际研究 由加州大学圣地亚哥分校和许多其他机构的合作调查人员执行。 通过在项目开发的所有级别协助广泛不同学科的调查人员，从 研究执行、分析、解释和传播的假设概念化， NMC鼓励应用多种科学观点，并促进跨学科 合作与协调。通过各种灵活的机制，包括面对面的会议 和视频电话会议，我们将与神经成像、神经行为、 神经病毒学、神经生物学、发育和国际核心以促进HNRC的 跨学科目标。

Advances in antiretroviral therapy have reduced but not eliminated mortality and neurologic morbidity related to HIV infection. The epidemic has been transformed into a chronic disease in which there is a dynamic equilibrium between mechanisms maintaining viral persistence and host immune strategies that, in combination with antiretroviral therapy, hold viral activity in check. Prospects for eradication or cure are many years or decades away. Looking toward the future, the HNRC perceives four general areas in which research needs are greatest. In the renewal period, the Neuromedical Core (NMC) will therefore develop and mature its research infrastructure to support studies addressing the themes of aging, acute and early HIV infection and clinical relevance. A common thread linking these three themes is genetics-both host and viral. The newly-organized NMC is made up of two cooperative units comprising common resources (equipment, supplies) and staff that interact on a daily basis: a Clinical Research Support Unit (CRSU); and a Laboratory, Pharmacology & Biomarker Unit (LPBU). Together these units will perform evaluations on all HIV+ subjects and HIV- controls, including those enrolled in pilot studies of the Developmental Core. The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and laboratory evaluations, scientific consultation, and mentorship, training, and community education in NeuroAIDS. In the current funding period the NMC facilitated 70 research projects including observational cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research performed by collaborating investigators at UCSD and many other institutions. By assisting investigators in widely diverging disciplines at all levels of project development, from conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary collaboration and coordination. Through a variety of flexible mechanisms including face-to-face meetings and video teleconferences we will collaborate closely with the Neuroimaging, Neurobehavioral, Neurovirology, Neurobiology, Developmental and International Cores to further the HNRC's transdisciplinary aims.