Animal Histopathology Core Facility

动物组织学核心机构 Lineberger综合癌症中心对人类疾病的小鼠模型有着重大的战略承诺。多个教师在他们的研究中使用这些模型，以探索癌症病因学和生物学，并越来越多地测试新化合物和多模式疗法的治疗效果。动物研究的一个重要终点是病理学评价和原位分子分析;这些有助于 确定治疗效果、潜在毒性和疾病发病机制。LCCC动物组织学核心（AHC）的目标是为生物医学研究社区提供高质量，负担得起的组织学和分子病理学支持。AHC通过方便的校园位置，可定制的服务，补贴价格以及获得董事会认证的兽医病理学家来增加价值。主要 服务包括组织包埋及切片（冰冻及石蜡切片），常规及特殊染色，以及动物研究设计，组织收集及病理学解释的谘询。2008年，所有基本的组织学设备都进行了升级，以提高产量和自动化程度; 2009年，增加了第三名全职组织技术专家和一名自动免疫染色仪。会员可优先使用大多数服务，并享有50%或更高的折扣。 学院院长是Arlin Rogers，他是ACVP认证的病理学家，在研究中使用动物模型有超过15年的经验。除了他对肝癌发生的独立研究外，他在过去的七年中还指导了动物组织病理学核心。设施主任珍妮丝韦弗是一个高度熟练的组织技术专家和实验室管理员。在目前的领导下，自上次竞争性更新以来，年生产率提高了61%。2009年，核心服务于代表7个研究项目的52个成员用户。2010年，核心要求121,382美元的CCSG资金，占其运营成本的27%; 88%的程序是去年为癌症中心成员执行的。未来的计划包括免疫组织化学和原位杂交服务收费，快速周转时间和日常提交的优良质量的维护，并支持包括小鼠I期单位和协作交叉的动物研究计划。

Animal Histopathology Core Faciiity The UNC Lineberger Comprehensive Cancer Center has a major strategic commitment to mouse models of human disease. Multiple faculty use these models in their research funded to probe cancer etiology and biology, and increasingly to test therapeutic efficacy of novel compounds and multimodality therapies. An important endpoints of animal studies are pathologic evaluation and in situ molecular analysis; these help to determine therapeutic efficacy, potential toxicity, and disease pathogenesis. The goal of the LCCC Animal Histopathology Core (AHC) is to provide high quality, affordable histology and molecular pathology support to the UNC biomedical research community. The AHC adds value through a convenient campus location, customizable services, subsidized pricing, and access to board-certified veterinary pathologists. Major services include tissue embedding and sectioning (frozen and paraffin), routine and special stains, and consultation on animal study design, tissue collection and pathologic interpretation. In 2008 all of the basic histology equipment was upgraded to increase throughput and automation; in 2009 a third FTE histotechnologist and an automated immunostainer were added. Members receive priority access and a 50% or greater discount for most services. The Faculty Director is Arlin Rogers, an ACVP-certified pathologist with more than 15 years of experience using animal models in research. In addition to his independent studies on liver carcinogenesis, he has directed animal histopathology cores for the past seven years. Facility Director Janice Weaver is a highly skilled histotechnologist and laboratory administrator. Under current leadership, annual productivity increased 61% since the last competing renewal. In 2009, the Core served 52 member users representing 7 research programs. For 2010, the Core requests $121,382 in CCSG funds, representing 27% of its operating costs; 88% of procedures were performed for cancer center members last year. Future plans include fee-for service immunohistochemistry and in situ hybridization, maintenance of rapid turnaround times and excellent quality of routine submissions, and support for UNC animal research initiatives including the Mouse Phase I Unit and the Collaborative Cross.