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Animal Histopathology Core Facility

动物组织病理学核心设施

基本信息

批准号：
8594144
负责人：
ARLIN B ROGERS
金额：
$ 20.8万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8594144
关键词：
Administrator Animal Experimentation Animal Model Animals Automation Biological Assay Biology Biomedical Research Cancer Biology Cancer Center Cancer Center Support Grant Cancer Etiology Combined Modality Therapy Communities Consultations Core Facility Discipline Disease Documentation Equipment Evaluation Faculty Fee-for-Service Plans Frozen Sections Funding Future Genetically Engineered Mouse Goals Grant Harvest Hematoxylin and Eosin Staining Method Hepatocarcinogenesis Histologic Histology Histopathology Immunohistochemistry In Situ In Situ Hybridization Laboratories Leadership Lesion Link Location Maintenance Modeling Molecular Molecular Analysis Mus Outcome Paraffin Pathogenesis Pathologic Pathologist Pathology Performance Phase Phenotype Preparation Price Procedures Productivity Protocols documentation Research Research Design Research Personnel Services Specimen Staining method Stains Testing Time Tissue Banks Tissue Embedding Tissue Stains Tissues Toxic effect Treatment Efficacy UNC Lineberger Comprehensive Cancer Center Work base cancer therapy cost cost effective discount experience human disease member molecular pathology mouse model novel preclinical study programs success tool

项目摘要

Animal Histopathology Core Faciiity The UNC Lineberger Comprehensive Cancer Center has a major strategic commitment to mouse models of human disease. Multiple faculty use these models in their research funded to probe cancer etiology and biology, and increasingly to test therapeutic efficacy of novel compounds and multimodality therapies. An important endpoints of animal studies are pathologic evaluation and in situ molecular analysis; these help to determine therapeutic efficacy, potential toxicity, and disease pathogenesis. The goal of the LCCC Animal Histopathology Core (AHC) is to provide high quality, affordable histology and molecular pathology support to the UNC biomedical research community. The AHC adds value through a convenient campus location, customizable services, subsidized pricing, and access to board-certified veterinary pathologists. Major services include tissue embedding and sectioning (frozen and paraffin), routine and special stains, and consultation on animal study design, tissue collection and pathologic interpretation. In 2008 all of the basic histology equipment was upgraded to increase throughput and automation; in 2009 a third FTE histotechnologist and an automated immunostainer were added. Members receive priority access and a 50% or greater discount for most services. The Faculty Director is Arlin Rogers, an ACVP-certified pathologist with more than 15 years of experience using animal models in research. In addition to his independent studies on liver carcinogenesis, he has directed animal histopathology cores for the past seven years. Facility Director Janice Weaver is a highly skilled histotechnologist and laboratory administrator. Under current leadership, annual productivity increased 61% since the last competing renewal. In 2009, the Core served 52 member users representing 7 research programs. For 2010, the Core requests $121,382 in CCSG funds, representing 27% of its operating costs; 88% of procedures were performed for cancer center members last year. Future plans include fee-for service immunohistochemistry and in situ hybridization, maintenance of rapid turnaround times and excellent quality of routine submissions, and support for UNC animal research initiatives including the Mouse Phase I Unit and the Collaborative Cross.

动物组织病理学核心设施北卡罗来纳大学莱恩伯格综合癌症中心对人类疾病的小鼠模型有着重大的战略承诺。许多教师在他们资助的研究中使用这些模型来探索癌症病因学和生物学，并越来越多地测试新化合物和多种疗法的治疗效果。动物研究的一个重要终点是病理评估和原位分子分析；这些有助于确定治疗效果、潜在毒性和疾病发病机制。LCCC动物组织病理学核心(AHC)的目标是为北卡罗来纳大学的生物医学研究社区提供高质量、负担得起的组织学和分子病理学支持。AHC通过便利的校园位置、可定制的服务、补贴定价和获得委员会认证的兽医病理学家的机会来增加价值。主修服务包括组织包埋和切片(冰冻和石蜡切片)、常规和特殊染色，以及动物研究设计、组织收集和病理解释的咨询。2008年，所有基本的组织学设备都进行了升级，以提高产量和自动化程度；2009年，又增加了第三名FTE组织技术员和一台自动免疫标记仪。会员可以优先使用，大多数服务可享受50%或更高的折扣。学院主任是Arlin Rogers，他是一位获得ACVP认证的病理学家，有15年以上使用动物模型进行研究的经验。除了他对肝癌发生的独立研究外，他在过去的七年里还指导了动物组织病理学的核心。设施主任贾尼斯·韦弗是一位技术高超的组织技术学家和实验室管理员。在现任领导人的领导下，自上次竞争更新以来，年生产率提高了61%。2009年，Core为代表7个研究项目的52名成员用户提供了服务。2010年，Core申请CCSG资金121,382美元，占其运营成本的27%；去年88%的手术是为癌症中心成员进行的。未来的计划包括收费的免疫组织化学和原位杂交服务，保持快速周转时间和高质量的常规提交，以及支持北卡罗来纳大学的动物研究倡议，包括小鼠第一阶段单位和合作交叉。