UAB Center for AIDS Research

阿拉巴马大学艾滋病研究中心

• 批准号: 8306299
• 负责人: Michael S. Saag
• 金额: $ 488.27万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306299
• 关键词: AIDS Treatment Research; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Area; Basic Science; Behavioral; Behavioral Research; Behavioral Sciences; Chronic; Clinical; Clinical Data; Clinical Investigator; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Computerized Medical Record; Contracts; Core Facility; Culture Techniques; Cytotoxic T-Lymphocytes; Databases; Detection; Development; Discipline; Effectiveness; Epidemic; Epidemiologic Studies; Evolution; Extramural Activities; Faculty; Flow Cytometry; Fostering; Funding; Genome; Grant; Growth; HIV; HIV Infections; HIV-1; Human; Infection; Institutes; Instruction; Interdisciplinary Study; International; Intervention; Laboratories; Leadership; Link; Location; Medical Informatics; Medicine; Mental disorders; Mentors; Methods; Minority; Mission; Molecular Virology; NIH Grants and Contracts; Nature; Operations Research; Outcome; Outcomes Research; Peer Review; Phase; Plasma; Play; Prevention; Prevention strategy; Preventive Intervention; Productivity; Program Development; Proteome; Publications; RNA; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Role; Science; Services; Sexual Health; Site; Specimen; Strategic Planning; Substance abuse problem; System; Therapeutic; Training; Translational Research; United States; United States National Institutes of Health; Universities; Viral; Viral Pathogenesis; behavioral/social science; effective therapy; global health; innovation; interest; member; multidisciplinary; neutralizing antibody; novel; programs; success; vaccine development; virology; virus culture

DESCRIPTION (provided by applicant): The mission of the UAB CFAR is to stimulate and support multidisciplinary basic, behavioral, clinical and translational AIDS research so as to hasten the development of effective treatments and prevention strategies for AIDS. For 20 years, the Center has played a vital role in supporting cutting edge research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasispecies diversity (Nature 1988), detection of HIV-1 RNA in plasma (Science 1993), viral dynamics in acute and chronic infection (NEJM 1991; Nature 1995), HIV-1 escape from cytotoxic T-cells (Nat Medicine 1997) and neutralizing antibodies (Nature 2003), first-in-human phase 1 clinical studies of 7 currently approved therapies (NEJM 1993; Nat Medicine 1998; JAMA 2006), the zoonotic origins of HIV-1 (Nature 1999; Nature 2006; Science 2006), and the identification of the transmitted HIV-1 envelope and complete genome/proteome responsible for HIV infection (PNAS 2008). A common thread connecting all of these discoveries is the proactive participation of the CFAR in facilitating basic, translational and clinical research through effective collaboration between basic and clinical investigators. The objectives of the CFAR reflect this continuing commitment to innovative, multidisciplinary AIDS research and include: 1. To provide a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. To enhance productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. To use robust strategic planning methods to identify new research opportunities and priorities, to align them with existing CFAR programs, and to foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs. This is accomplished through mentoring young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research and the global epidemic. The Center is comprised of 163 Center members from 35 Divisions and Departments within UAB funded by current AIDS-related grants and contracts totaling more than $87.2 million. Nine Core Facilities are proposed that provide vital support for the Center's principal thematic areas of viral pathogenesis, experimental therapeutics, global health, prevention and vaccine development. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in NIH extramural funding for AIDS-related research from $6.0 million in NIH funding in 1988 to over $26 million currently, in over 2500 research publications over the past six year grant period, in the recruitment of more than 21 HIV/AIDS investigators since 2QQ2, and in the garnering of strong Institutional support.

描述(由申请者提供)：UAB CFAR的使命是鼓励和支持多学科的基础、行为、临床和翻译艾滋病研究，以加速开发有效的艾滋病治疗和预防策略。20年来，该中心在支持其成员的尖端研究活动方面发挥了至关重要的作用，这些活动导致了范式转变的发现，包括：发现艾滋病毒-1准物种多样性(自然1988)，检测血浆中的艾滋病毒-1RNA(科学1993)，急性和慢性感染中的病毒动力学(NEJM 1991；自然1995)，艾滋病毒-1逃避细胞毒性T细胞(NAT医学1997)和中和抗体(自然2003)，对目前批准的7种治疗方法进行的人类第一阶段临床研究(NEJM 1993；NAT医学1998；JAMA 2006)，艾滋病毒-1的人畜起源(自然1999；2006年《自然》杂志；2006年《科学》杂志；以及识别传播的艾滋病毒-1包膜和导致艾滋病毒感染的完整基因组/蛋白质组(PNAS，2008年)。连接所有这些发现的一个共同主线是CFAR通过基础和临床研究人员之间的有效合作，积极参与促进基础、转化和临床研究。CFAR的目标反映了这种对创新、多学科艾滋病研究的持续承诺，并包括：1.为艾滋病毒/艾滋病研究活动提供一个中心机构重点，强调CFAR成员和更广泛的艾滋病毒/艾滋病研究界之间的有效沟通和合作。2.通过鼓励跨学科研究和向中心调查人员提供关键的共享资源设施以及行政和财政管理支持，提高正在进行的研究方案的生产率。3.使用强有力的战略规划方法来确定新的研究机会和优先事项，使其与现有的CFAR计划保持一致，并在教师兴趣和大学能力明显的情况下培养新的研究计划。4.鼓励初级和资深教员参加艾滋病毒/艾滋病研究方案。这是通过指导年轻的研究人员和同行审查的发展赠款计划来实现的。5.在反映艾滋病毒/艾滋病研究和全球流行病不断演变的领域促进教师招聘和方案发展。该中心由来自UAB内35个司和部门的163名中心成员组成，资金来自目前与艾滋病有关的赠款和合同，总额超过8720万美元。拟议的九个核心设施为该中心的主要主题领域--病毒发病机制、实验疗法、全球卫生、预防和疫苗开发--提供重要支持。UAB CFAR在刺激艾滋病毒/艾滋病研究方面的成功体现在：NIH为艾滋病相关研究提供的外部资金从1988年的600万美元增加到目前的2600万美元，在过去六年的赠款期间发表了2500多份研究出版物，自第二季度以来招聘了21名艾滋病毒/艾滋病调查人员，并获得了强有力的机构支持。