Molecular Imaging High Throughtput Screening

分子成像高通量筛选

• 批准号: 8195501
• 负责人: David Piwnica-Worms
• 金额: $ 6.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195501
• 关键词: Cancer Center; Cellular biology; Comprehensive Cancer Center; Developmental Biology; Fees; Funding; Gifts; Grant; Institutes; Medical; Molecular Bank; Process; Radiology Specialty; Resource Development; Resources; Robotics; Screening procedure; TNFRSF5 gene; Time; United States National Institutes of Health; Universities; Washington; high throughput screening; in vivo Cellular and Molecular Imaging Centers; medical schools; molecular imaging; operation; programs; ranpirnase; response

In response to the NIH Roadmap to Molecular Libraries and Imaging, we conceived the process and now have fully established a P50 ICMIC High Throughput Screening Robotics Core. Core initiation represented a multi-departmental effort with fiscal support for establishing the Core coming from PSO funds in combination with the Department of Radiology, Department of Developmental Biology, and the Howard Hughes Medical Institute. The Dean of Washington University School of Medicine as well as the Director of the Washington University Siteman Cancer Center joined our effort with the commitment of additional funds for further development of the resource. Overall, nearly $2M was invested in the establishment of this resource, which has been in operation since late 2006. Since that time, the HTS Core has operated as a matrix core, receiving funds from the PSO ICMIC grant, the Siteman Cancer Center (through a gift of Emerson/Busch as well as funds as a Developing Core of the P30 NCI Comprehensive Cancer Center grant), and recharge fees to users. This Core serves as an outstanding on-going example of how our PSO program has leveraged university resources and continues to stimulate interdisciplinary molecular imaging activity throughout the WU campus. Functionally and symbolically, Drs. Helen Piwnica-Worms (Cell Biology), Rafi Kopan (Developmental Biology), and David Piwnica-Worms (Radiology) serve as Core Co-Directors with shared administration and scientific oversight of Core activities. The PSO funds effort for David Piwnica-Worms, while the Siteman funds effort for Helen Piwnica-Worms and Rafi Kopan.

为了响应NIH的路线图和分子库和成像，我们构思了过程和 现在已经完全建立了P50 ICMIC高通量筛选机器人技术核心。核心启动代表 一项多部门的努力，并为建立来自PSO资金的核心的财政支持组合 与放射学系，发育生物学系和霍华德·休斯医学 研究所。华盛顿大学医学院的院长以及华盛顿的主任 大学现场癌症中心加入了我们的努力，以额外的资金承诺进一步 资源的发展。总体而言，将近200万美元用于建立此资源，该资源 自2006年底以来一直在运营。自那时以来，HTS核心已作为矩阵核心运行，接收 来自现场癌症中心PSO ICMIC Grant的资金（通过Emerson/Busch的礼物以及资金 作为P30 NCI综合癌症中心补助金的发展核心），并向用户充电。这 核心是我们的PSO计划如何利用大学的杰出持续示例 资源并继续刺激整个WU的跨学科分子成像活性 校园。在功能和象征上，Drs。 Helen Piwnica-Worms（细胞生物学），Rafi Kopan （发育生物学）和David Piwnica-Worms（放射学）作为核心联合导演 共同的管理和科学监督核心活动。 David的PSO资金努力 Piwnica-Worms，而现场人士为Helen Piwnica-Worms和Rafi Kopan提供了资金。