Molecular Imaging High Throughtput Screening

作为对NIH分子图书馆和成像路线图的响应，我们设想了这一过程和 现已完全建立了P50 ICMIC高通量筛选机器人核心。以核心启动为代表 多部门努力，财政支持，建立核心来自PSO基金的组合 与放射科、发育生物学系和霍华德·休斯医学院 研究所。华盛顿大学医学院院长兼华盛顿医学院院长 大学西特曼癌症中心加入了我们的努力，并承诺进一步提供更多资金 资源的开发。总体而言，在建立这一资源方面投入了近200万美元，其中 自2006年底以来一直在运营。从那时起，HTS Core一直作为矩阵核心运行，接收 来自PSO ICMIC赠款、Siteman癌症中心的资金(通过Emerson/Busch的捐赠以及资金 作为P30 NCI综合癌症中心赠款的开发核心)，并向用户收取充值费用。这 CORE是我们的PSO计划如何利用大学的一个杰出的持续例子 资源，并继续在整个WU中刺激跨学科的分子成像活动 校园里。在功能和象征意义上，海伦·皮维尼卡-蠕虫博士(细胞生物学)，拉菲·科潘 (发育生物学)和David Piwnica-Worms(放射学)担任核心联席董事 共享管理和对核心活动的科学监督。PSO为大卫的努力提供资金 Siteman为海伦·Piwnica-蠕虫和Rafi Kopan的努力提供资金。

In response to the NIH Roadmap to Molecular Libraries and Imaging, we conceived the process and now have fully established a P50 ICMIC High Throughput Screening Robotics Core. Core initiation represented a multi-departmental effort with fiscal support for establishing the Core coming from PSO funds in combination with the Department of Radiology, Department of Developmental Biology, and the Howard Hughes Medical Institute. The Dean of Washington University School of Medicine as well as the Director of the Washington University Siteman Cancer Center joined our effort with the commitment of additional funds for further development of the resource. Overall, nearly $2M was invested in the establishment of this resource, which has been in operation since late 2006. Since that time, the HTS Core has operated as a matrix core, receiving funds from the PSO ICMIC grant, the Siteman Cancer Center (through a gift of Emerson/Busch as well as funds as a Developing Core of the P30 NCI Comprehensive Cancer Center grant), and recharge fees to users. This Core serves as an outstanding on-going example of how our PSO program has leveraged university resources and continues to stimulate interdisciplinary molecular imaging activity throughout the WU campus. Functionally and symbolically, Drs. Helen Piwnica-Worms (Cell Biology), Rafi Kopan (Developmental Biology), and David Piwnica-Worms (Radiology) serve as Core Co-Directors with shared administration and scientific oversight of Core activities. The PSO funds effort for David Piwnica-Worms, while the Siteman funds effort for Helen Piwnica-Worms and Rafi Kopan.