Molecular Imaging High Throughtput Screening

分子成像高通量筛选

• 批准号: 8195501
• 负责人: David Piwnica-Worms
• 金额: $ 6.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195501
• 关键词: Cancer Center; Cellular biology; Comprehensive Cancer Center; Developmental Biology; Fees; Funding; Gifts; Grant; Institutes; Medical; Molecular Bank; Process; Radiology Specialty; Resource Development; Resources; Robotics; Screening procedure; TNFRSF5 gene; Time; United States National Institutes of Health; Universities; Washington; high throughput screening; in vivo Cellular and Molecular Imaging Centers; medical schools; molecular imaging; operation; programs; ranpirnase; response

In response to the NIH Roadmap to Molecular Libraries and Imaging, we conceived the process and now have fully established a P50 ICMIC High Throughput Screening Robotics Core. Core initiation represented a multi-departmental effort with fiscal support for establishing the Core coming from PSO funds in combination with the Department of Radiology, Department of Developmental Biology, and the Howard Hughes Medical Institute. The Dean of Washington University School of Medicine as well as the Director of the Washington University Siteman Cancer Center joined our effort with the commitment of additional funds for further development of the resource. Overall, nearly $2M was invested in the establishment of this resource, which has been in operation since late 2006. Since that time, the HTS Core has operated as a matrix core, receiving funds from the PSO ICMIC grant, the Siteman Cancer Center (through a gift of Emerson/Busch as well as funds as a Developing Core of the P30 NCI Comprehensive Cancer Center grant), and recharge fees to users. This Core serves as an outstanding on-going example of how our PSO program has leveraged university resources and continues to stimulate interdisciplinary molecular imaging activity throughout the WU campus. Functionally and symbolically, Drs. Helen Piwnica-Worms (Cell Biology), Rafi Kopan (Developmental Biology), and David Piwnica-Worms (Radiology) serve as Core Co-Directors with shared administration and scientific oversight of Core activities. The PSO funds effort for David Piwnica-Worms, while the Siteman funds effort for Helen Piwnica-Worms and Rafi Kopan.

为了响应NIH分子文库和成像路线图，我们构思了该过程， 现在已经完全建立了一个P50 ICMIC高吞吐量筛选机器人核心。核心启动代表 由多部门共同努力，在PSO基金的财政支持下， 放射学系、发育生物学系和霍华德休斯医学中心 院华盛顿大学医学院院长以及华盛顿 大学Siteman癌症中心加入了我们的努力，承诺提供额外资金， 资源的开发。总的来说，为建立这一资源投入了近200万美元， 自2006年底开始运作。从那时起，HTS核心一直作为矩阵核心运行， 来自PSO ICMIC赠款、Siteman癌症中心（通过Emerson/Busch的礼物以及基金）的资金 作为P30 NCI综合癌症中心赠款的发展核心），并向用户充值费用。这 核心作为一个杰出的持续的例子，我们的PSO计划如何利用大学 资源，并继续刺激跨学科的分子成像活动在整个华盛顿大学 校园从功能和象征意义上讲，海伦·皮温妮卡-沃姆斯博士（细胞生物学），拉菲·科潘 （发育生物学）和大卫Piwnica-Worms（放射学）担任核心联合主任， 对核心活动进行共同管理和科学监督。PSO为大卫提供资金 皮温尼卡蠕虫，而Siteman资金的努力海伦皮温尼卡蠕虫和拉菲科潘。