Administrative Core
行政核心
基本信息
- 批准号:8195493
- 负责人:
- 金额:$ 66.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressBasic ScienceBiochemical ReactionBiological AssayBone Marrow TransplantationCellsChemistryClinical ResearchCollaborationsDiagnosticDisciplineEpigenetic ProcessEventExplosionFoundationsGene ExpressionImageInflammationInstructionInterdisciplinary StudyLeadLibrariesLifeLymphocyteMalignant NeoplasmsMedical ImagingMetabolic stressMolecularMonitorMusOrganismPatientsPilot ProjectsPositron-Emission TomographyPostdoctoral FellowProcessRegulatory PathwayReporterResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRoboticsSignal TransductionSignaling ProteinSmall Interfering RNASpecialized CenterStudentsTechniquesTherapeuticTraining ProgramsTransgenic OrganismsTranslational ResearchTumorigenicityUniversitiesViralWashingtonWhole Organismcancer therapychemical geneticsclinical applicationfundamental researchgenetically modified cellshigh throughput screeningin vivoin vivo Cellular and Molecular Imaging Centersinterdisciplinary collaborationinterestmolecular imagingmolecular oncologymultidisciplinarynotch proteinnovelprognosticprogramstrafficking
项目摘要
Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions,
signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington
University Molecular Imaging Center directs major efforts into fundamental, translational and clinical
research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques
and probes in combination with genetically-encoded reporters to pinpoint molecular events within target
cells.
The Washington University Molecular Imaging Center activities have spurred an explosion of
collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions
in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of
collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded
reporter strategies that allow the molecular characterization of cancer in vivo for basic research as
well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study
regulated signal transduction and protein processing in living organisms. The principal research projects
address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as
targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in
doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during
epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow
transplant. The program also includes three molecular imaging scientific resources: the molecular imaging
reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging
platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics.
Our Molecular Imaging Center also provides a pilot project program for new investigators and a
multidisciplinary training program for students, post-docs, and fellows.
突破性的分子成像研究已经将基因表达、生化反应、
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Piwnica-Worms其他文献
David Piwnica-Worms的其他文献
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{{ truncateString('David Piwnica-Worms', 18)}}的其他基金
First-in-Human Imaging of Innate Immunity Activation with a Redox-Tuned PET Reporter
使用氧化还原调谐 PET 报告基因首次对人体进行先天免疫激活成像
- 批准号:
10577531 - 财政年份:2023
- 资助金额:
$ 66.14万 - 项目类别:
Imaging and Characterizating Stress responses in vivo with p21 Reporter Mice
使用 p21 报告小鼠对体内应激反应进行成像和表征
- 批准号:
8195496 - 财政年份:2012
- 资助金额:
$ 66.14万 - 项目类别:
PET Imaging of GVHD and GVL after treatment with Azacitidine
阿扎胞苷治疗后 GVHD 和 GVL 的 PET 成像
- 批准号:
8195498 - 财政年份:2012
- 资助金额:
$ 66.14万 - 项目类别:
Core A: Molecular Imaging Reporter Core (MIRC)
核心 A:分子成像报告核心 (MIRC)
- 批准号:
7287034 - 财政年份:2007
- 资助金额:
$ 66.14万 - 项目类别:
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