Administrative Core

突破性的分子成像研究可视化了基因表达，生化反应， 活体细胞和整个生物体中的信号转导和调节通路。华盛顿邮报 大学分子成像中心将主要工作引向基础、翻译和临床 新技术在癌症成像信号转导和治疗中的研究 与基因编码的记者相结合的探测器，以精确定位目标内的分子事件 细胞。 华盛顿大学分子成像中心的活动刺激了 协作的、跨学科的研究项目，形成了激动人心的新方向的基础 在分子成像方面。一支敬业的调查团队展示了一项非凡的记录 他们在自己学科之外的合作导致了人们对应用新的基因编码的兴趣不断上升 允许将体内癌症的分子特征用于基础研究的记者策略 以及诊断和预后临床应用。特别是，这导致了一个需要研究重大主题 生物体中受调控的信号转导和蛋白质处理。主要研究项目 解决癌症中Notch信号的成像，调查代谢应激和检查点控制 抗癌治疗的靶点，研究炎症和病毒诱导的致瘤性之间的相互作用 双转基因报告鼠，并监测转基因细胞与PET在 骨髓移植患者供体淋巴细胞的表观遗传调节 移植。该计划还包括三个分子成像科学资源：分子成像 记者核心、化学核心和高通量筛选机器人核心，建立在分子成像基础上 广泛的生物分析读数平台，包括siRNA文库筛选和化学遗传学。 我们的分子成像中心还为新的研究人员提供试点项目计划和 面向学生、博士后和研究员的多学科培训计划。

Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions, signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington University Molecular Imaging Center directs major efforts into fundamental, translational and clinical research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques and probes in combination with genetically-encoded reporters to pinpoint molecular events within target cells. The Washington University Molecular Imaging Center activities have spurred an explosion of collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded reporter strategies that allow the molecular characterization of cancer in vivo for basic research as well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study regulated signal transduction and protein processing in living organisms. The principal research projects address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow transplant. The program also includes three molecular imaging scientific resources: the molecular imaging reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics. Our Molecular Imaging Center also provides a pilot project program for new investigators and a multidisciplinary training program for students, post-docs, and fellows.