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Administrative Core

行政核心

基本信息

批准号：
8195493
负责人：
David Piwnica-Worms
金额：
$ 66.14万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8195493
关键词：
Address Basic Science Biochemical Reaction Biological Assay Bone Marrow Transplantation Cells Chemistry Clinical Research Collaborations Diagnostic Discipline Epigenetic Process Event Explosion Foundations Gene Expression Image Inflammation Instruction Interdisciplinary Study Lead Libraries Life Lymphocyte Malignant Neoplasms Medical Imaging Metabolic stress Molecular Monitor Mus Organism Patients Pilot Projects Positron-Emission Tomography Postdoctoral Fellow Process Regulatory Pathway Reporter Research Infrastructure Research Personnel Research Project Grants Resources Robotics Signal Transduction Signaling Protein Small Interfering RNA Specialized Center Students Techniques Therapeutic Training Programs Transgenic Organisms Translational Research Tumorigenicity Universities Viral Washington Whole Organism cancer therapy chemical genetics clinical application fundamental research genetically modified cells high throughput screening in vivo in vivo Cellular and Molecular Imaging Centers interdisciplinary collaboration interest molecular imaging molecular oncology multidisciplinary notch protein novel prognostic programs trafficking

项目摘要

Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions, signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington University Molecular Imaging Center directs major efforts into fundamental, translational and clinical research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques and probes in combination with genetically-encoded reporters to pinpoint molecular events within target cells. The Washington University Molecular Imaging Center activities have spurred an explosion of collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded reporter strategies that allow the molecular characterization of cancer in vivo for basic research as well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study regulated signal transduction and protein processing in living organisms. The principal research projects address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow transplant. The program also includes three molecular imaging scientific resources: the molecular imaging reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics. Our Molecular Imaging Center also provides a pilot project program for new investigators and a multidisciplinary training program for students, post-docs, and fellows.

突破性的分子成像研究已经将基因表达、生化反应、