Administrative Core

行政核心

基本信息

批准号：
8195493
负责人：
David Piwnica-Worms
金额：
$ 66.14万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8195493
关键词：
Address Basic Science Biochemical Reaction Biological Assay Bone Marrow Transplantation Cells Chemistry Clinical Research Collaborations Diagnostic Discipline Epigenetic Process Event Explosion Foundations Gene Expression Image Inflammation Instruction Interdisciplinary Study Lead Libraries Life Lymphocyte Malignant Neoplasms Medical Imaging Metabolic stress Molecular Monitor Mus Organism Patients Pilot Projects Positron-Emission Tomography Postdoctoral Fellow Process Regulatory Pathway Reporter Research Infrastructure Research Personnel Research Project Grants Resources Robotics Signal Transduction Signaling Protein Small Interfering RNA Specialized Center Students Techniques Therapeutic Training Programs Transgenic Organisms Translational Research Tumorigenicity Universities Viral Washington Whole Organism cancer therapy chemical genetics clinical application fundamental research genetically modified cells high throughput screening in vivo in vivo Cellular and Molecular Imaging Centers interdisciplinary collaboration interest molecular imaging molecular oncology multidisciplinary notch protein novel prognostic programs trafficking

项目摘要

Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions, signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington University Molecular Imaging Center directs major efforts into fundamental, translational and clinical research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques and probes in combination with genetically-encoded reporters to pinpoint molecular events within target cells. The Washington University Molecular Imaging Center activities have spurred an explosion of collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded reporter strategies that allow the molecular characterization of cancer in vivo for basic research as well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study regulated signal transduction and protein processing in living organisms. The principal research projects address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow transplant. The program also includes three molecular imaging scientific resources: the molecular imaging reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics. Our Molecular Imaging Center also provides a pilot project program for new investigators and a multidisciplinary training program for students, post-docs, and fellows.

开创性的分子成像研究已可视化基因表达，生化反应，活体内活细胞和整个生物的信号转导和调节途径。华盛顿大学分子成像中心将重大努力用于基本，转化和临床使用新技术的成像信号转导和疗法的成像信号转导和疗法的研究并与遗传编码的记者结合使用探针，以查明目标内的分子事件细胞。华盛顿大学分子成像中心的活动激发了协作，跨学科研究项目为令人兴奋的新方向奠定了基础在分子成像中。一个专门的调查人员团队证明了在自己的学科之外的合作，导致对应用新颖的遗传编码的兴趣不断提高记者策略允许体内癌症的分子表征进行基础研究以及诊断和预后临床应用。特别是，这导致了研究的主要主题在生物体中调节信号转导和蛋白质加工。主要研究项目解决癌症中缺口信号的成像，研究代谢应力和检查点控制抗癌治疗的靶标，研究炎症和病毒诱导的肿瘤性的相互作用双重转基因报道小鼠，并在遗传改性细胞的运输过程中用PET进行运输在接受骨髓的患者的临床研究中，供体淋巴细胞的表观遗传调节移植。该程序还包括三个分子成像科学资源：分子成像记者核心，化学核心和高吞吐量筛选机器人核心，建立在分子成像上用于读取各种生物测定的平台，包括siRNA库屏幕和化学遗传学。我们的分子成像中心还为新研究人员提供了一个试点项目计划针对学生，毕业后和研究员的多学科培训计划。