Administrative Core

行政核心

• 批准号: 8195493
• 负责人: David Piwnica-Worms
• 金额: $ 66.14万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195493
• 关键词: Address; Basic Science; Biochemical Reaction; Biological Assay; Bone Marrow Transplantation; Cells; Chemistry; Clinical Research; Collaborations; Diagnostic; Discipline; Epigenetic Process; Event; Explosion; Foundations; Gene Expression; Image; Inflammation; Instruction; Interdisciplinary Study; Lead; Libraries; Life; Lymphocyte; Malignant Neoplasms; Medical Imaging; Metabolic stress; Molecular; Monitor; Mus; Organism; Patients; Pilot Projects; Positron-Emission Tomography; Postdoctoral Fellow; Process; Regulatory Pathway; Reporter; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Robotics; Signal Transduction; Signaling Protein; Small Interfering RNA; Specialized Center; Students; Techniques; Therapeutic; Training Programs; Transgenic Organisms; Translational Research; Tumorigenicity; Universities; Viral; Washington; Whole Organism; cancer therapy; chemical genetics; clinical application; fundamental research; genetically modified cells; high throughput screening; in vivo; in vivo Cellular and Molecular Imaging Centers; interdisciplinary collaboration; interest; molecular imaging; molecular oncology; multidisciplinary; notch protein; novel; prognostic; programs; trafficking

Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions, signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington University Molecular Imaging Center directs major efforts into fundamental, translational and clinical research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques and probes in combination with genetically-encoded reporters to pinpoint molecular events within target cells. The Washington University Molecular Imaging Center activities have spurred an explosion of collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded reporter strategies that allow the molecular characterization of cancer in vivo for basic research as well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study regulated signal transduction and protein processing in living organisms. The principal research projects address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow transplant. The program also includes three molecular imaging scientific resources: the molecular imaging reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics. Our Molecular Imaging Center also provides a pilot project program for new investigators and a multidisciplinary training program for students, post-docs, and fellows.

突破性的分子成像研究使基因表达、生化反应 活细胞和整个生物体内的信号转导和调节途径。华盛顿酒店 大学分子影像中心将主要精力投入到基础，转化和临床 以成像信号传导和使用新技术的癌症治疗为主题的研究 以及探针与遗传编码的报告物组合以精确定位靶内的分子事件 细胞 华盛顿大学分子影像中心的活动引发了 合作，跨学科的研究项目，已形成了令人兴奋的新方向的基础 在分子成像中。一支专门的调查团队已经展示了出色的记录， 在他们自己的学科之外的合作，导致对应用新的基因编码的兴趣不断上升。 报告策略，允许在基础研究中对癌症进行体内分子表征， 以及诊断和预后临床应用。特别是，这导致了一个重大主题的研究 调节生物体中的信号转导和蛋白质加工。主要研究项目 解决癌症中Notch信号传导的成像，研究代谢应激和检查点控制， 抗癌治疗的靶点，研究炎症和病毒诱导的致瘤性的相互作用， 双转基因报告小鼠，并监测运输的基因修饰的细胞与PET期间 在接受骨髓移植的患者的临床研究中供体淋巴细胞的表观遗传调节 移植该计划还包括三个分子成像科学资源：分子成像 报告核心、化学核心和高通量筛选机器人核心，建立在分子成像基础上 用于读取各种生物测定的平台，包括siRNA文库筛选和化学遗传学。 我们的分子影像中心还为新的研究人员提供试点项目计划， 为学生、博士后和研究员提供的多学科培训计划。