Administrative Core

行政核心

基本信息

  • 批准号:
    8195493
  • 负责人:
  • 金额:
    $ 66.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

Ground-breaking molecular imaging studies have visualized gene expression, biochemical reactions, signal transduction and regulatory pathways in living cells and whole organisms in vivo. The Washington University Molecular Imaging Center directs major efforts into fundamental, translational and clinical research under the theme of imaging signal transduction and therapeutics in cancer using novel techniques and probes in combination with genetically-encoded reporters to pinpoint molecular events within target cells. The Washington University Molecular Imaging Center activities have spurred an explosion of collaborative, interdisciplinary research projects that have formed the foundation for exciting new directions in molecular imaging. A dedicated team of investigators have demonstrated an exceptional record of collaboration outside their own disciplines leading to an escalating interest in applying novel geneticallyencoded reporter strategies that allow the molecular characterization of cancer in vivo for basic research as well as diagnostic and prognostic clinical applications. In particular, this has lead to a major theme to study regulated signal transduction and protein processing in living organisms. The principal research projects address imaging of Notch signaling in cancer, investigate metabolic stress and checkpoint controls as targets for anticancer therapy, investigate the interaction of inflammation and viral-induced tumorigenicity in doubly transgenic reporter mice, and monitor trafficking of genetically-modified cells with PET during epigenetic modulation of donor lymphocytes in a clinical study of patients undergoing bone marrow transplant. The program also includes three molecular imaging scientific resources: the molecular imaging reporter core, chemistry core and high throughput screening robotics core, founded on molecular imaging platforms for readout of a wide range of bio-assays, including siRNA library screens, and chemical genetics. Our Molecular Imaging Center also provides a pilot project program for new investigators and a multidisciplinary training program for students, post-docs, and fellows.
突破性的分子成像研究已经将基因表达、生化反应、

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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David Piwnica-Worms其他文献

David Piwnica-Worms的其他文献

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{{ truncateString('David Piwnica-Worms', 18)}}的其他基金

First-in-Human Imaging of Innate Immunity Activation with a Redox-Tuned PET Reporter
使用氧化还原调谐 PET 报告基因首次对人体进行先天免疫激活成像
  • 批准号:
    10577531
  • 财政年份:
    2023
  • 资助金额:
    $ 66.14万
  • 项目类别:
Molecular Imaging Core
分子成像核心
  • 批准号:
    10517142
  • 财政年份:
    2022
  • 资助金额:
    $ 66.14万
  • 项目类别:
Molecular Imaging Core
分子成像核心
  • 批准号:
    10707122
  • 财政年份:
    2022
  • 资助金额:
    $ 66.14万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    8658378
  • 财政年份:
    2014
  • 资助金额:
    $ 66.14万
  • 项目类别:
Molecular Imaging Reporter
分子影像记者
  • 批准号:
    8195499
  • 财政年份:
    2012
  • 资助金额:
    $ 66.14万
  • 项目类别:
Molecular Imaging High Throughtput Screening
分子成像高通量筛选
  • 批准号:
    8195501
  • 财政年份:
    2012
  • 资助金额:
    $ 66.14万
  • 项目类别:
Imaging and Characterizating Stress responses in vivo with p21 Reporter Mice
使用 p21 报告小鼠对体内应激反应进行成像和表征
  • 批准号:
    8195496
  • 财政年份:
    2012
  • 资助金额:
    $ 66.14万
  • 项目类别:
PET Imaging of GVHD and GVL after treatment with Azacitidine
阿扎胞苷治疗后 GVHD 和 GVL 的 PET 成像
  • 批准号:
    8195498
  • 财政年份:
    2012
  • 资助金额:
    $ 66.14万
  • 项目类别:
Core A: Molecular Imaging Reporter Core (MIRC)
核心 A:分子成像报告核心 (MIRC)
  • 批准号:
    7287034
  • 财政年份:
    2007
  • 资助金额:
    $ 66.14万
  • 项目类别:
Administration
行政
  • 批准号:
    7287029
  • 财政年份:
    2007
  • 资助金额:
    $ 66.14万
  • 项目类别:

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HNDS-R: Connectivity, Inclusiveness, and the Permeability of Basic Science
HNDS-R:基础科学的连通性、包容性和渗透性
  • 批准号:
    2318404
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    $ 66.14万
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    Standard Grant
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Computer Vision for Malaria Microscopy: Automated Detection and Classification of Plasmodium for Basic Science and Pre-Clinical Applications
用于疟疾显微镜的计算机视觉:用于基础科学和临床前应用的疟原虫自动检测和分类
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    10576701
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    2023
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    $ 66.14万
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Bringing together communities and basic science researchers to build stronger relationships
将社区和基础科学研究人员聚集在一起,建立更牢固的关系
  • 批准号:
    480914
  • 财政年份:
    2023
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    $ 66.14万
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    Miscellaneous Programs
“L-form” bacteria: basic science, antibiotics, evolution and biotechnology
L 型细菌:基础科学、抗生素、进化和生物技术
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Coordinating and Data Management Center for Translational and Basic Science Research in Early Lesions
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  • 财政年份:
    2022
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    $ 66.14万
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Developing science communication on large scale basic science represented by accelerator science
发展以加速器科学为代表的大规模基础科学科学传播
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    10588228
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    $ 66.14万
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    10431468
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