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Molecular Imaging Reporter

分子影像记者

基本信息

批准号：
8195499
负责人：
David Piwnica-Worms
金额：
$ 15.75万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8195499
关键词：
Adverse effects Caloric Restriction Cancer Patient Cells Cessation of life Chemoprotective Agent Clinical Trials Clinical effectiveness DNA Damage Development Dose Effectiveness Engineering Etoposide Fasting Fatigue Firefly Luciferases Food deprivation (experimental)Genotoxic Stress Growth Heart High Dose Chemotherapy Hypothalamic structure Instruction Intervention Ionizing radiation Knockout Mice Literature Malignant neoplasm of prostate Mediating Metabolic Metabolism Molecular Mus Mutation Neurons Neutropenia Normal Cell Normal tissue morphology Organ PTEN gene Pathway interactions Publishing Radiation therapy Radio Reporter Reporting Role Signal Pathway Starvation Testing Therapeutic Time Topoisomerase Toxic effect Universities Washington Xenograft procedure cancer cell cancer type chemotherapy dietary restriction effective intervention feeding gastrointestinal inhibitor/antagonist irinotecan killings molecular imaging mouse model neoplastic cell novel oncoprotein p21 preconditioning programs promoter research study response transcription factor tumor

项目摘要

The Molecular Imaging Reporter Core (IVIIRC) is a central facility (See GENERAL RESOURCES AND ENVIR0NI\/1ENT). David Piwnica-Worms, PSO PI, also serves as Reporter Core Director. Julie Prior, B.S., is the Senior Core Manager. Ms. Prior is a seasoned Medical Research Lab Manager with 15 years experience in biomedical research/molecular imaging projects, and has been a part ofthe PSO ICMIC program here at Washington University since its inception. She has extensive experience with cell biology, tracer assays, biochemistry and all aspects of bioluminescence animal and cellular imaging as well as lab management. She is the primary technical investigator and directs two FTE's engaged in active experimentation, cloning of MIRC reporter genes, engineering constructs, and managing a catalog of vector systems for general use in reporting the regulation of genes of interest for scientists involved with ICMIC activities. Julie also actively participates in discovery research projects. The MIRC not only develops and generates new reporter constructs, cell lines and geneticallyengineered animals, but also provides expertise, materials and collaborative assistance for design and execution of the biological aspects of molecular imaging. The MIRC serves investigators with a wide range of resources and experience in niolecular biology, mammalian cell culture, and small animal experimentation. One of the most important service activities of this core is dissemination of our newly developed molecular imaging reagents and geneticallyencoded reporters to investigators within our institution, to other PSO program sites and to cancer biology investigators throughout the world (Figure 1). The MIRC has been and continues to be one of our most productive and comprehensive cores, impacting a broad range of programs throughout the world through our discovery research activities.

分子成像报告核心（IVIIRC）是一个中心设施(参见一般资源和