Molecular Imaging Reporter
分子影像记者
基本信息
- 批准号:8195499
- 负责人:
- 金额:$ 15.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsCaloric RestrictionCancer PatientCellsCessation of lifeChemoprotective AgentClinical TrialsClinical effectivenessDNA DamageDevelopmentDoseEffectivenessEngineeringEtoposideFastingFatigueFirefly LuciferasesFood deprivation (experimental)Genotoxic StressGrowthHeartHigh Dose ChemotherapyHypothalamic structureInstructionInterventionIonizing radiationKnockout MiceLiteratureMalignant neoplasm of prostateMediatingMetabolicMetabolismMolecularMusMutationNeuronsNeutropeniaNormal CellNormal tissue morphologyOrganPTEN genePathway interactionsPublishingRadiation therapyRadioReporterReportingRoleSignal PathwayStarvationTestingTherapeuticTimeTopoisomeraseToxic effectUniversitiesWashingtonXenograft procedurecancer cellcancer typechemotherapydietary restrictioneffective interventionfeedinggastrointestinalinhibitor/antagonistirinotecankillingsmolecular imagingmouse modelneoplastic cellnoveloncoprotein p21preconditioningprogramspromoterresearch studyresponsetranscription factortumor
项目摘要
The Molecular Imaging Reporter Core (IVIIRC) is a central facility (See GENERAL RESOURCES AND
ENVIR0NI\/1ENT). David Piwnica-Worms, PSO PI, also serves as Reporter Core Director. Julie Prior,
B.S., is the Senior Core Manager. Ms. Prior is a seasoned Medical Research Lab Manager with 15 years
experience in biomedical research/molecular imaging projects, and has been a part ofthe PSO ICMIC program
here at Washington University since its inception. She has extensive experience with cell biology, tracer
assays, biochemistry and all aspects of bioluminescence animal and cellular imaging as well as lab
management. She is the primary technical investigator and directs two FTE's engaged in active
experimentation, cloning of MIRC reporter genes, engineering constructs, and managing a catalog of vector
systems for general use in reporting the regulation of genes of interest for scientists involved with
ICMIC activities. Julie also actively participates in discovery research projects.
The MIRC not only develops and generates new reporter constructs, cell lines and geneticallyengineered
animals, but also provides expertise, materials and collaborative assistance for design
and execution of the biological aspects of molecular imaging. The MIRC serves investigators
with a wide range of resources and experience in niolecular biology, mammalian cell culture, and
small animal experimentation. One of the most important service activities of this core
is dissemination of our newly developed molecular imaging reagents and geneticallyencoded
reporters to investigators within our institution, to other PSO program sites and to cancer biology investigators throughout the world (Figure 1). The MIRC has been and continues to be one of our most productive and comprehensive cores, impacting a broad range of programs throughout the world through our discovery research activities.
分子成像报告核心 (IVIIRC) 是一个中央设施(参见一般资源和
ENVIR0NI\/1ENT)。 David Piwnica-Worms,PSO PI,还担任 Reporter 核心总监。朱莉·普赖尔,
B.S.,是高级核心经理。 Prior 女士是一位拥有 15 年经验的医学研究实验室经理
拥有生物医学研究/分子成像项目经验,并曾参与 PSO ICMIC 项目
自华盛顿大学成立以来一直在这里。她在细胞生物学、示踪剂方面拥有丰富的经验
分析、生物化学以及生物发光动物和细胞成像以及实验室的各个方面
管理。她是主要技术调查员,并指导两名 FTE 从事积极的工作
实验、MIRC 报告基因克隆、工程构建和管理载体目录
一般用于报告科学家感兴趣的基因调控的系统
ICMIC活动。朱莉还积极参与发现研究项目。
MIRC 不仅开发和生成新的报告构建体、细胞系和基因工程
动物,还为设计提供专业知识、材料和协作帮助
和执行分子成像的生物学方面。 MIRC 为调查人员提供服务
在分子生物学、哺乳动物细胞培养和
小动物实验。该核心最重要的服务活动之一
正在传播我们新开发的分子成像试剂和基因编码
向我们机构内的研究人员、其他 PSO 项目站点以及世界各地的癌症生物学研究人员报告记者(图 1)。 MIRC 一直是并将继续成为我们最具生产力和最全面的核心之一,通过我们的发现研究活动影响世界各地的广泛项目。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Piwnica-Worms其他文献
David Piwnica-Worms的其他文献
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{{ truncateString('David Piwnica-Worms', 18)}}的其他基金
First-in-Human Imaging of Innate Immunity Activation with a Redox-Tuned PET Reporter
使用氧化还原调谐 PET 报告基因首次对人体进行先天免疫激活成像
- 批准号:
10577531 - 财政年份:2023
- 资助金额:
$ 15.75万 - 项目类别:
Imaging and Characterizating Stress responses in vivo with p21 Reporter Mice
使用 p21 报告小鼠对体内应激反应进行成像和表征
- 批准号:
8195496 - 财政年份:2012
- 资助金额:
$ 15.75万 - 项目类别:
PET Imaging of GVHD and GVL after treatment with Azacitidine
阿扎胞苷治疗后 GVHD 和 GVL 的 PET 成像
- 批准号:
8195498 - 财政年份:2012
- 资助金额:
$ 15.75万 - 项目类别:
Core A: Molecular Imaging Reporter Core (MIRC)
核心 A:分子成像报告核心 (MIRC)
- 批准号:
7287034 - 财政年份:2007
- 资助金额:
$ 15.75万 - 项目类别:
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