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Molecular Imaging Reporter

分子影像记者

基本信息

批准号：
8195499
负责人：
David Piwnica-Worms
金额：
$ 15.75万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8195499
关键词：
Adverse effects Caloric Restriction Cancer Patient Cells Cessation of life Chemoprotective Agent Clinical Trials Clinical effectiveness DNA Damage Development Dose Effectiveness Engineering Etoposide Fasting Fatigue Firefly Luciferases Food deprivation (experimental)Genotoxic Stress Growth Heart High Dose Chemotherapy Hypothalamic structure Instruction Intervention Ionizing radiation Knockout Mice Literature Malignant neoplasm of prostate Mediating Metabolic Metabolism Molecular Mus Mutation Neurons Neutropenia Normal Cell Normal tissue morphology Organ PTEN gene Pathway interactions Publishing Radiation therapy Radio Reporter Reporting Role Signal Pathway Starvation Testing Therapeutic Time Topoisomerase Toxic effect Universities Washington Xenograft procedure cancer cell cancer type chemotherapy dietary restriction effective intervention feeding gastrointestinal inhibitor/antagonist irinotecan killings molecular imaging mouse model neoplastic cell novel oncoprotein p21 preconditioning programs promoter research study response transcription factor tumor

项目摘要

The Molecular Imaging Reporter Core (IVIIRC) is a central facility (See GENERAL RESOURCES AND ENVIR0NI\/1ENT). David Piwnica-Worms, PSO PI, also serves as Reporter Core Director. Julie Prior, B.S., is the Senior Core Manager. Ms. Prior is a seasoned Medical Research Lab Manager with 15 years experience in biomedical research/molecular imaging projects, and has been a part ofthe PSO ICMIC program here at Washington University since its inception. She has extensive experience with cell biology, tracer assays, biochemistry and all aspects of bioluminescence animal and cellular imaging as well as lab management. She is the primary technical investigator and directs two FTE's engaged in active experimentation, cloning of MIRC reporter genes, engineering constructs, and managing a catalog of vector systems for general use in reporting the regulation of genes of interest for scientists involved with ICMIC activities. Julie also actively participates in discovery research projects. The MIRC not only develops and generates new reporter constructs, cell lines and geneticallyengineered animals, but also provides expertise, materials and collaborative assistance for design and execution of the biological aspects of molecular imaging. The MIRC serves investigators with a wide range of resources and experience in niolecular biology, mammalian cell culture, and small animal experimentation. One of the most important service activities of this core is dissemination of our newly developed molecular imaging reagents and geneticallyencoded reporters to investigators within our institution, to other PSO program sites and to cancer biology investigators throughout the world (Figure 1). The MIRC has been and continues to be one of our most productive and comprehensive cores, impacting a broad range of programs throughout the world through our discovery research activities.

分子成像报告核心 (IVIIRC) 是一个中央设施（参见一般资源和 ENVIR0NI\/1ENT)。 David Piwnica-Worms，PSO PI，还担任 Reporter 核心总监。朱莉·普赖尔, B.S.，是高级核心经理。 Prior 女士是一位拥有 15 年经验的医学研究实验室经理拥有生物医学研究/分子成像项目经验，并曾参与 PSO ICMIC 项目自华盛顿大学成立以来一直在这里。她在细胞生物学、示踪剂方面拥有丰富的经验分析、生物化学以及生物发光动物和细胞成像以及实验室的各个方面管理。她是主要技术调查员，并指导两名 FTE 从事积极的工作实验、MIRC 报告基因克隆、工程构建和管理载体目录一般用于报告科学家感兴趣的基因调控的系统 ICMIC活动。朱莉还积极参与发现研究项目。 MIRC 不仅开发和生成新的报告构建体、细胞系和基因工程动物，还为设计提供专业知识、材料和协作帮助和执行分子成像的生物学方面。 MIRC 为调查人员提供服务在分子生物学、哺乳动物细胞培养和小动物实验。该核心最重要的服务活动之一正在传播我们新开发的分子成像试剂和基因编码向我们机构内的研究人员、其他 PSO 项目站点以及世界各地的癌症生物学研究人员报告记者（图 1）。 MIRC 一直是并将继续成为我们最具生产力和最全面的核心之一，通过我们的发现研究活动影响世界各地的广泛项目。