Animal Core

该项目的目标是开发安全有效的新型抗结核疫苗。 因此，涉及强毒结核菌株的动物实验是关键和必要的组成部分 动物中心，一个最先进的，配备齐全的设施，努力提供一个安全，高效， 和成本效益的环境进行实验，使用各种鼠结核 模型，将提供宝贵的服务，动物研究建议在每一个三个项目的 方案项目提案。动物核心的主要目标是为该计划的研究人员提供 成功进行动物实验所需的技术支持和培训项目 这是成功开发新型疫苗所必需的。PI和动物核心的工作人员， 在小鼠结核病模型方面有丰富的经验，也将协助实验设计。作为 作为一个服务于三个单独组成部分的中心计划，动物核心有望促进现有资源的共享（例如，特种小鼠的繁殖和维护），刺激科学交流和合作，以及培训对以下方面感兴趣的缺乏经验的年轻研究人员： 鼠结核病模型。在上一个资助期内，大量缺乏动物实验经验的研究人员接受了培训，在我们的生物安全3级动物核心中工作。此外，物理扩展使可供方案项目调查人员使用的空间增加了一倍。 最后但并非最不重要的是，已购置了许多新的设备，包括两台Baker/麦迪逊雾化机，目前已全面投入使用，大大提高了设施的效率。 根据上一个资助期取得的进展，动物核心显然已经实现了其目标。我们期望动物核心继续发挥重要作用，促进动物实验的所有研究人员谁参加了计划项目。

The goal of this Program Project is to develop novel anti-tuberculosis vaccines that are safe and effective. Therefore, animal experiments involving virulent tuberculosis strains are a critical and essential component of the POl. The Animal Core, a state-of-the-art, well-staffed facility that strives to provide a safe, efficient, and cost-effective environment for the conduction of experiments using a variety of murine tuberculosis models, will provide invaluable services for animal studies proposed in each of the three projects of the Program Project proposal. The major goal ofthe Animal Core is to provide researchers ofthe Program Project with the technical support and training necessary for successful conduction of animal experiments that are requisite to successful development of novel vaccines. The PI and the staff of the Animal Core, who have extensive experience in modeling tuberculosis in mice, will also assist in experimental design. As a central program that services three individual components, the Animal Core can be expected to foster sharing of the resources available (for example, breeding and maintenance of specialty mice), stimulate scientific exchanges and collaboration, as well as train inexperienced young investigators interested in murine tuberculosis models. A substantial number of researchers inexperienced in animal experimentation have been trained to work in our biosafety level 3 Animal Core in the last funding period. In addition, physical expansion has let to doubling of the amount of space available for use by the Program Project investigators. Last but not least, many new pieces of equipment have been acquired including two Baker/Madison aerosolization machines that are currently fully operative, have greatly enhanced the efficiency of the facility. Based on the progress made in the last funding period, the Animal Core has clearly fulfilled its goals. We anticipate the Animal Core to continue to play an important role in facilitating animal experimentation for all the researchers who participate in the Program Project.