Animal Core

该计划项目的目标是开发安全有效的新型抗结核病疫苗。 因此，涉及强毒结核菌株的动物实验是一个关键和必要的组成部分。 波兰人。动物核心，一个最先进的，配备齐全的设施，努力提供安全，高效， 使用多种小鼠结核病进行实验的经济高效的环境 模型，将为三个项目中的每一个提出的动物研究提供宝贵的服务 计划项目建议书。动物核心的主要目标是为该计划的研究人员提供 为成功进行动物实验提供必要的技术支持和培训的项目 这是成功开发新型疫苗所必需的。少年派和动物核心的工作人员，谁 在建立小鼠结核病模型方面有丰富的经验，也将协助实验设计。作为一名 作为为三个单独部分提供服务的中央计划，动物核心有望促进现有资源的共享(例如，特殊小鼠的饲养和维护)，促进科学交流和合作，以及培训对以下问题感兴趣的缺乏经验的年轻研究人员 小鼠结核病模型。在上一次资助期间，大量在动物实验方面缺乏经验的研究人员接受了在我们的生物安全3级动物核心项目工作的培训。此外，物理扩展使可供项目调查员使用的空间量翻了一番。 最后但并非最不重要的一点是，已经购买了许多新设备，包括两台贝克/麦迪逊喷雾机，目前已完全投入使用，极大地提高了设施的效率。 基于上一个资助期取得的进展，动物核心明确实现了其目标。我们预计动物核心将继续在促进所有参与该计划项目的研究人员进行动物实验方面发挥重要作用。

The goal of this Program Project is to develop novel anti-tuberculosis vaccines that are safe and effective. Therefore, animal experiments involving virulent tuberculosis strains are a critical and essential component of the POl. The Animal Core, a state-of-the-art, well-staffed facility that strives to provide a safe, efficient, and cost-effective environment for the conduction of experiments using a variety of murine tuberculosis models, will provide invaluable services for animal studies proposed in each of the three projects of the Program Project proposal. The major goal ofthe Animal Core is to provide researchers ofthe Program Project with the technical support and training necessary for successful conduction of animal experiments that are requisite to successful development of novel vaccines. The PI and the staff of the Animal Core, who have extensive experience in modeling tuberculosis in mice, will also assist in experimental design. As a central program that services three individual components, the Animal Core can be expected to foster sharing of the resources available (for example, breeding and maintenance of specialty mice), stimulate scientific exchanges and collaboration, as well as train inexperienced young investigators interested in murine tuberculosis models. A substantial number of researchers inexperienced in animal experimentation have been trained to work in our biosafety level 3 Animal Core in the last funding period. In addition, physical expansion has let to doubling of the amount of space available for use by the Program Project investigators. Last but not least, many new pieces of equipment have been acquired including two Baker/Madison aerosolization machines that are currently fully operative, have greatly enhanced the efficiency of the facility. Based on the progress made in the last funding period, the Animal Core has clearly fulfilled its goals. We anticipate the Animal Core to continue to play an important role in facilitating animal experimentation for all the researchers who participate in the Program Project.