ANIMAL CORE

动物核心

• 批准号: 8231924
• 负责人: TODD E MORGAN
• 金额: $ 32.98万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8231924
• 关键词: Age; Aging; Alzheimer' s Disease; Animal Model; Animals; Autopsy; Basic Science; Behavior; Bioenergetics; Biological; Biological Markers; Birth; Brain; Breeding; Clinical Research; Collection; Cytology; Development; Diet; Disease; Electrophysiology (science); Enrollment; Ensure; Fatty acid glycerol esters; Gene Expression; Genes; Human; Image; In Situ Hybridization; Inflammatory; Instruction; Irrigation; Knowledge; Lead; Link; Menopause; Metabolic; Mission; Molecular Profiling; Mus; Neurologic; Obesity; Online Systems; Ovarian; Ovarian hormone; Ovariectomy; Pap smear; Pathology; Pathway interactions; Perimenopause; Phenotype; Principal Investigator; Process; Rattus; Records; Risk; Rodent Model; Serum; Sprague-Dawley Rats; Staging; Subgroup; System; Time; Tissue Banks; Tissue Sample; Tissues; Translating; Vagina; Woman; aged; aging brain; data management; density; genetic analysis; hormone therapy; innovation; middle age; nervous system disorder; prevent; programs; reproductive; senescence; success

The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to discover the biological changes that occur in the brain during the perimenopausal transition which can result in phenotypes predictive of risk for development of Alzheimer's pathology. We seek to identify the mechanisms by which these changes occur, and translate these discoveries to determine the optimal timing and strategies for preventing conversion to the perimenopausal at-risk phenotype. To achieve our mission, we will determine the perimenopausal phenotypes associated with different cycle transition states; delineate the mechanistic pathways involved in cJevelopment of these phenotypes; and assess the impact of ovarian hormone and high-fat diet induced obesity (DIO) on expression of Alzheimer's disease biomarkers. The mission of Animal Core (Core B) is to ensure the success ofthe Perimenopause Program Project through provision of animals as neecled to Projects 1-3. To achieve its mission. Animal Core will develop rodent models of perimenopause and menopause; maintain and track animals from acquisition or birth, though determination of cycling status, study enrollment, experimental manipulation, to fissue collection across the entire Perimenopause Program Project; and obtain tissue samples for storage and genetic analyses by Analytic Core. RELEVANCE (See Instructions): The complexity of the perimenopausal process has been a major barrier to both basic and clinical research of this aging transition in women. Development of rodent models ofthe human perimenopause is critical to advancing knowledge ofthe effects ofthe perimenopause on the brain, identifying phenotypes at risk for age-associated neurological diseases, and developing strategies that promote healthy neurological aging in women to prevent age-associated diseases such as Alzheimer's.

我们的围绝经期脑老化和阿尔茨海默病项目(P3)的使命是 发现在围绝经期过渡期间大脑中发生的生物学变化 在预测阿尔茨海默氏病发病风险的表型上。我们试图找出 这些变化发生的机制，并将这些发现转化为确定最佳时机 以及防止转变为围绝经期高危表型的策略。为了完成我们的使命， 我们将确定与不同周期转换状态相关的围绝经期表型；描绘 参与这些表型发育的机制途径；并评估卵巢的影响 激素和高脂饮食诱导肥胖(DIO)对阿尔茨海默病生物标志物表达的影响。 动物核心(核心B)的使命是确保围绝经期计划项目的成功 通过按照项目1-3的要求提供动物。来完成它的使命。动物核心将会发展 围绝经期和更年期的啮齿动物模型；维护和跟踪动物从获取或出生， 通过自行车状态的确定、研究招生、实验操作，来裂解收藏 在整个围绝经期计划项目中；并获取组织样本用于存储和遗传 Analytic Core的分析。 相关性(请参阅说明)： 围绝经期过程的复杂性一直是基础和临床研究的主要障碍。 女性的这一老龄化转变。人类围绝经期啮齿动物模型的建立对 提高对围绝经期对大脑影响的知识，识别存在高血压风险的表型 与年龄相关的神经疾病，以及开发促进健康神经衰老的策略 预防老年痴呆症等与年龄相关的疾病。