Animal and Biostatics Core

动物和生物统计学核心

• 批准号: 8036466
• 负责人: TODD E MORGAN
• 金额: $ 46.06万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8036466
• 关键词: Age; Animal Experiments; Animals; Appearance; Archives; Arts; Autopsy; Behavior; Biological; Biostatistics Core; Blocking Antibodies; Blood; Body Weight; Bone Marrow; Brain; Breast; Breeding; C57BL/6 Mouse; Cardiac; Cataloging; Catalogs; Cell Aging; Cells; Cellular Stress; Collection; DNA; Development; Disease; Doxorubicin; Ensure; Environment; Exposure to; Fasting; Fibrinogen; Freezing; GRP78 gene; Genetic; Genotype; Growth; Growth Factor; Heart; Histopathology; Housing; Inbred BALB C Mice; Incidence; Individual; Injection of therapeutic agent; Instruction; Insulin; Insulin-Like Growth Factor I; Kidney; Liver; Longevity; Lung; Malignant Epithelial Cell; Malignant Neoplasms; Microscopic; Molecular; Monitor; Mus; Noise; Organ; Outcome; Oxidants; Paraquat; Partner in relationship; Pathology; Pathway interactions; Pharmaceutical Preparations; Physical activity; Prevention; Principal Investigator; Procedures; Proteins; Protocols documentation; Publications; Records; Research; Resistance; Sampling; Security; Signal Transduction; Somatotropin; Source; Spleen; Starvation; Stress; Tissue Banks; Tissues; Work; age related; cell growth; chemotherapy; design; dietary restriction; improved; in vivo; meetings; molecular phenotype; mortality; mouse model; offspring; oxidative damage; programs; receptor; research study; tumor

The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in support of the overall program hypothesis that the understanding of the mechanisms of dietary restriction and reduced growth hormone/insulin growth factor (GH/IGF) signaling-dependent cellular protection can be applied to the prevention and treatment of age-related diseases. Mouse breeding colonies of unique genetic and molecular phenotypes which target specific tissue or cellular GH/IGF pathways are the source of offspring to be characterized for longevity, stress resistance, spontaneous cancer development and protection from oxidative damage and established chemotherapy drugs. The core provides an integrative framework for assessment of common outcomes across the individual projects needs. RELEVANCE (See instructions): The Animal and Biostatistics Core will apply the expertise of its leaders to improve the design, execution, interpretation, and publication of all animal studies proposed in this program project. The Animal and Biostatistics Core will monitor all animal experiments using specific mouse models and standardized experimental protocols to provide an integrative framework for assessment of common outcomes across the individual projects.

动物和生物统计核心将直接与项目负责人合作，设计、规划、监测和 解释所有动物实验，并提供特定的小鼠模型和标准化实验 支持总体计划假设的协议，即对饮食机制的理解 限制和减少生长激素/胰岛素生长因子 (GH/IGF) 信号依赖性细胞 保护可应用于预防和治疗与年龄有关的疾病。小鼠繁殖群体 针对特定组织或细胞 GH/IGF 途径的独特遗传和分子表型是 具有长寿、抗压、自发癌症发展特征的后代来源 以及防止氧化损伤和既定化疗药物的保护。核心提供了一个 用于评估各个项目需求的共同成果的综合框架。 相关性（参见说明）： 动物和生物统计核心将运用其领导者的专业知识来改进设计、执行、 解释并出版该计划项目中提出的所有动物研究。动物和 生物统计核心将使用特定的小鼠模型和标准化来监测所有动物实验 实验方案为评估整个领域的共同结果提供综合框架 个人项目。