Animal and Biostatics Core

动物和生物统计学核心

• 批准号: 8036466
• 负责人: TODD E MORGAN
• 金额: $ 46.06万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8036466
• 关键词: Age; Animal Experiments; Animals; Appearance; Archives; Arts; Autopsy; Behavior; Biological; Biostatistics Core; Blocking Antibodies; Blood; Body Weight; Bone Marrow; Brain; Breast; Breeding; C57BL/6 Mouse; Cardiac; Cataloging; Catalogs; Cell Aging; Cells; Cellular Stress; Collection; DNA; Development; Disease; Doxorubicin; Ensure; Environment; Exposure to; Fasting; Fibrinogen; Freezing; GRP78 gene; Genetic; Genotype; Growth; Growth Factor; Heart; Histopathology; Housing; Inbred BALB C Mice; Incidence; Individual; Injection of therapeutic agent; Instruction; Insulin; Insulin-Like Growth Factor I; Kidney; Liver; Longevity; Lung; Malignant Epithelial Cell; Malignant Neoplasms; Microscopic; Molecular; Monitor; Mus; Noise; Organ; Outcome; Oxidants; Paraquat; Partner in relationship; Pathology; Pathway interactions; Pharmaceutical Preparations; Physical activity; Prevention; Principal Investigator; Procedures; Proteins; Protocols documentation; Publications; Records; Research; Resistance; Sampling; Security; Signal Transduction; Somatotropin; Source; Spleen; Starvation; Stress; Tissue Banks; Tissues; Work; age related; cell growth; chemotherapy; design; dietary restriction; improved; in vivo; meetings; molecular phenotype; mortality; mouse model; offspring; oxidative damage; programs; receptor; research study; tumor

The Animal and Biostatistics Core will work directly with Project Leaders to design, plan, monitor and interpret all animal experiments, as well as, provide specific mouse models and standardized experimental protocols in support of the overall program hypothesis that the understanding of the mechanisms of dietary restriction and reduced growth hormone/insulin growth factor (GH/IGF) signaling-dependent cellular protection can be applied to the prevention and treatment of age-related diseases. Mouse breeding colonies of unique genetic and molecular phenotypes which target specific tissue or cellular GH/IGF pathways are the source of offspring to be characterized for longevity, stress resistance, spontaneous cancer development and protection from oxidative damage and established chemotherapy drugs. The core provides an integrative framework for assessment of common outcomes across the individual projects needs. RELEVANCE (See instructions): The Animal and Biostatistics Core will apply the expertise of its leaders to improve the design, execution, interpretation, and publication of all animal studies proposed in this program project. The Animal and Biostatistics Core will monitor all animal experiments using specific mouse models and standardized experimental protocols to provide an integrative framework for assessment of common outcomes across the individual projects.

动物和生物统计核心将直接与项目负责人合作，设计、规划、监测和 解释所有动物实验，以及提供特定的小鼠模型和标准化的实验 协议支持总体方案假说，即对饮食机制的理解 限制和减少生长激素/胰岛素生长因子(GH/IGF)信号依赖细胞 保护可用于预防和治疗与年龄有关的疾病。小鼠繁殖群体 针对特定组织或细胞GH/IGF途径的独特遗传和分子表型是 后代的来源将以长寿、抗压、自发癌症发展为特征 以及防止氧化损伤和已有的化疗药物。该核心提供了一个 评估各个项目需要的共同成果的综合框架。 相关性(请参阅说明)： 动物和生物统计核心将应用其领导人的专业知识来改进设计、执行、 解释和出版本计划项目中提出的所有动物研究。《野兽》和 生物统计核心将监控所有使用特定小鼠模型和标准化的动物实验 实验方案，以提供一个综合框架，以评估在 个别项目。