Statistical Core

统计核心

• 批准号: 8036474
• 负责人: Charles B Hall
• 金额: $ 24.06万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8036474
• 关键词: Aging; Biological Process; Blood Vessels; Clinical; Cognitive; Collaborations; Complex; Data; Data Analyses; Data Quality; Databases; Ensure; Generations; Image; Instruction; Manuscripts; Measurement; Measures; Methodology; Modeling; Outcome; Pain; Positioning Attribute; Principal Investigator; Procedures; Quality Control; Research; Research Design; Research Personnel; Statistical Methods; Stress; System; Testing; clinical phenotype; data exchange; design; experience; indexing; innovation; neuroimaging; neuropathology; programs; success

The Statistical Core serves two functions that are essential for the success of the Einstein Aging Study (EAS). First, the Statistical Core maximizes data quality by implementing a database system that integrates and manages the data collected from the Administrative, Clinical, Neuropathology and Neuroimaging Cores, and from each of the four projects. The Statistical Core assumes responsibility for quality control procedures and for merging data across Projects and Cores. Second, the Statistical Core provides collaborative and consultative support to Project investigators on matters of study design, data analyses and interpretation of results. The Statistical Core is responsible for developing, implementing and interpreting statistical methods appropriate to specific research questions and hypotheses, and it collaborates regulariy with Project investigators on scientific manuscripts. Specific Aims of the Statistical Core are: Aim 1. To implement and oversee data procedures to facilitate the seamless exchange of data and ideas among Cores and Projects, and to facilitate data transfer for collaborations with investigators outside the EAS. Aim 2. To provide a general analytic framework for hypothesis testing, model building and integration of results and analyses across measurement constructs (e.g., exposures, mechanisms, outcomes), and to collaborate with investigators regarding the framing and testing of hypotheses and to provide expertise in the design and conduct of analyses. Aim 3. To develop new statistical methodology and to apply existing methodology in innovative ways to help to fulfill the other aims of this Core and the Projects and to further aging research in general. RELEVANCE (See instructions): The Statistical Core's contribution to the Program Project is essential and significant because it is needed (1) To ensure a high quality of data; (2) To ensure proper analysis of data for hypothesis testing and hypothesis generation; and (3) To ensure that the data collected in each project and core are optimally utilized for both project specific and cross-project analyses.

统计核心有两个功能，这对爱因斯坦衰老研究的成功至关重要。 （EAS）。首先，统计核心通过实施一个数据库系统， 并管理从管理、临床、神经病理学和神经成像核心收集的数据， 以及四个项目中的每一个。统计核心负责质量控制程序 以及跨项目和核心合并数据。第二，统计核心提供协作和 就研究设计、数据分析和 结果统计核心负责制定、实施和解释统计方法 适合特定的研究问题和假设，并且它定期与项目合作 科学手稿的研究者。 统计核心的具体目标是： 目标1。实施和监督数据程序，以促进数据和想法的无缝交换 核心和项目之间的数据传输，并促进与外部研究人员的合作 EAS。 目标2.为假设检验、模型建立和 跨测量构造的结果和分析（例如，风险、机制、结果），并 与研究人员合作，制定和测试假设，并提供专业知识， 设计和进行分析。 目标3。开发新的统计方法，并以创新的方式应用现有方法， 实现本核心和项目的其他目标，并进一步开展总体老龄化研究。 相关性（参见说明）： 统计核心对方案项目的贡献是必不可少和重要的，因为它是必要的（1） 确保数据的高质量;（2）确保对假设检验和假设的数据进行适当分析 （3）确保在每个项目和核心中收集的数据得到最佳利用， 具体项目和跨项目分析。