DYNAMIC CONTRAST ENHANCEMENT (DCE) MR IMAGING FOR NOVARTIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 总结：本方案共涵盖16只动物（4组，每组4只动物）。出于计划的目的，我们将动物分为成像组（成像组A和B），每个成像组中有4个处理组中的2只动物（每个成像组8只动物）。根据方案（A549-p100v4MRI.rt：2009年1月2日），每只动物将在4周内扫描4次（第-2、1、8和22天）。每次扫描将产生两个数据集-一个T2加权的6-12个图像集，用于计算肿瘤体积，一个DCE数据集涵盖20分钟内的造影剂摄取和洗脱-约40个图像。这将产生总共64个扫描会话，每个扫描会话产生52个图像，即总共3328个图像。该预算涵盖数据采集、分析和生成最终报告的费用。 MRI扫描方案： 安装/调试 10分钟 多层T2 30分钟 DCE 20分钟 549A 16只动物扫描4次

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Summary: This protocol covers a total of 16 animals (4 groups with 4 animals/group). For purposes of scheduling we will group the animals into Imaging groups (Image group A and B) with 2 animals from each of the 4 treatment groups in each Image group ( 8 animals per Imaging group). Each animal will be scanned 4 times (days -2,1,8, and 22) over the course of 4 weeks per the protocol (A549-p100v4MRI.rt: Jan2, 2009). Each scan will produce two datasets - a T2-weighted set of 6-12 images enabling calculation of tumor volume and a DCE dataset covering contrast uptake and washout over 20 minutes- ~ 40 images. This will yield a total of 64 scanning sessions each of which produces 52 images, i.e. a total of 3328 images. This budget covers the cost of data acquisition, analysis, and generation of a final report. MRI Scan Protocol: Setup/Locator 10 min Multislice T2 30 min DCE 20 min 549A 16 animals scanned 4 times