Air Pollution and Cognitive Function

空气污染与认知功能

• 批准号: 10598504
• 负责人: Charles B Hall
• 金额: $ 64.83万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-29 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598504
• 关键词: Acute; Address; Age; Aging; Air; Air Pollutants; Air Pollution; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Automobile Driving; Autopsy; Biological; Biological Markers; Blood Vessels; Brain Pathology; Cardiovascular system; Characteristics; Chronic; Cognition; Cognitive; Data; Data Collection; Dementia; Discrimination; Disparity; Ecological momentary assessment; Education; Ethnic Population; Event; Exposure to; Financial Hardship; Floor; Health; Heating; Heterogeneity; High Prevalence; Housing; Individual; Individual Differences; Indoor Air Quality; Inflammation; Intelligence; Life; Light; Magnetic Resonance Imaging; Measurement; Measures; Mediation; Memory; Methodology; Monitor; Neighborhoods; Nerve Degeneration; Neuropsychology; Participant; Pathology; Pathway interactions; Persons; Pollution; Predisposition; Probability; Public Health; Research; Respiratory Disease; Risk; Serum; Smoking; Source; Subgroup; Time; White Matter Hyperintensity; Woman; abeta accumulation; aged; apolipoprotein E-4; biomarker performance; cognitive change; cognitive function; cognitive performance; contextual factors; environmental stressor; ethnic difference; ethnic disparity; fine particles; frontal lobe; indexing; insight; men; mild cognitive impairment; monitoring device; neurofilament; non-verbal; perceived discrimination; racial difference; racial disparity; racial population; resilience; respiratory; sensor; social determinants; social health determinants; socioeconomic disparity; socioeconomics; study population; tau Proteins; traffic-related air pollution; verbal

ABSTRACT Fine particulate matter air pollution has been found to be associated with increased inflammation, respiratory disease, cardiovascular event risk, and cognitive changes and risk for Alzheimer’s Disease and Related Dementias (ADRD). Prior research has established that those exposed to higher levels of air pollution have higher levels of accumulated amyloid-beta (Aβ) and tau in frontal cortex at autopsy, higher error rates on cognitive function assessments, and lower scores on memory and both verbal and non-verbal intelligence assessments. In the US, exposure to high levels of air pollution is common, with substantial heterogeneity that is often associated with socioeconomic and racial/ethnic differences. Most research on the health effects of air pollution is based on outdoor ambient air quality measurements often supplemented by monitoring. This methodology cannot address contributions from indoor air quality and mobility in daily life, has limited geospatial precision, and cannot address individual differences in exposure and contextual factors (e.g., time spent indoor vs. outdoor, proximity to pollution sources, smoking, antiquated heating materials, and floor levels in buildings. This exposure misclassification likely results in significant biases towards the null in the estimation of the effects of air pollution. Commercially available, validated, wearable air quality sensors can accurately characterize person-specific air pollutant exposures to better understand how they relate to ADRD, and these will be used to assess exposure in this project. This Project, part of a renewal of the Einstein Aging Study (EAS; NIA P01 AG003949), will follow 767 diverse participants aged 60+ (dementia free at baseline) for up to 5 annual waves of data collection, collecting person-specific indices of exposure to fine particulate matter air pollution (PM1, PM2.5) to investigate the association of fine particulate matter exposure with cognition function and AD/ADRD (Specific Aim 1), biomarkers of neurodegeneration and vascular brain pathology (Specific Aim 2), and social determinants of health (Specific Aim 3). Establishing the association of person-specific air pollution exposure with momentary cognitive function, a biological pathway for that association, and how this association is modified by social determinants will yield insight into individual susceptibility and resilience to acute and chronic environmental stressors.

摘要 研究发现细颗粒物空气污染与炎症、呼吸道疾病增加有关 疾病、心血管事件风险、认知变化和阿尔茨海默病及相关疾病的风险 痴呆症（ADRD）。先前的研究已经确定，那些暴露于较高水平空气污染的人 尸检时额叶皮质中积累的淀粉样蛋白β（Aβ）和tau蛋白水平较高， 认知功能评估，记忆力以及语言和非语言智力得分较低 评估。在美国，暴露于高水平的空气污染是常见的，具有很大的异质性， 通常与社会经济和种族/民族差异有关。大多数关于空气对健康影响的研究 空气污染是以室外环境空气质量测量为基础的，通常辅之以监测。这 方法无法解决室内空气质量和日常生活中的流动性的贡献， 地理空间精度，并且不能解决暴露和背景因素中的个体差异（例如，时间 室内与室外的使用情况、与污染源的接近程度、吸烟、陈旧的供暖材料和地板高度 在建筑物中。这种暴露错误分类可能会导致估计中的零值出现显著偏差 空气污染的影响。商用的、经过验证的、可穿戴的空气质量传感器可以准确地 描述个人特定的空气污染物暴露，以更好地了解它们与ADRD的关系， 将用于评估本项目中的暴露。该项目是爱因斯坦衰老研究更新的一部分 (EAS; NIA P01 AG 003949），将随访767名年龄在60岁以上的不同参与者（基线时无痴呆）， 每年一次的数据收集浪潮，收集细颗粒物空气暴露的个人特定指数 污染（PM 1，PM2.5），探讨细颗粒物暴露与认知功能的关系 和AD/ADRD（特定目标1），神经变性和血管脑病理学的生物标志物（特定目标 2）和健康的社会决定因素（具体目标3）。建立个人专用空气协会 污染暴露与瞬时认知功能，这种关联的生物学途径，以及这是如何发生的。 社会决定因素对关联的影响将使人们深入了解个体对 急性和慢性环境应激源。