For how long is WTC exposure associated with chronic rhinosinusitis

接触世贸中心与慢性鼻窦炎的关系持续多久

• 批准号: 9275688
• 负责人: Charles B Hall
• 金额: $ 30.18万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-10 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275688
• 关键词: how; long; WTC; exposure; associated

DESCRIPTION (provided by applicant): Adverse short- and medium-term respiratory effects of work at the World Trade Center (WTC) disaster site have been widely documented in Fire Department of the City of New York (FDNY) first responders and others. Our FDNY team first reported WTC cough syndrome, demonstrated that work-related exposures to the disaster site increased the odds of aerodigestive symptoms up to nine years post-9/11, and showed that the prevalence of physician-diagnosed respiratory conditions, both self-reported and FDNY-physician diagnosed, remained elevated seven to nine years after working at the site. However, in contrast to hundreds of publications about WTC-related lower respiratory conditions, we found only 5 peer-reviewed publications that focused on upper airway disturbance, specifically chronic rhinosinusitis (CRS). In a current cooperative agreement with the National Institute of Occupational Safety and Health, we have been using innovative statistical methods - parametric survival models with change points - to examine whether the relationship between WTC-exposure and new onset obstructive airway disease was stable over the first post-9/11 decade or whether the observed association attenuated over time. Our preliminary results confirm the persistence of the exposure response/gradient for the cumulative incidence of disease for at least the first five years after exposure. We now propose to extend this methodology to address a similar question in CRS incidence, another common respiratory condition associated with exposure to the WTC rescue/recovery effort, with the goal of determining the length of time that exposure response gradients are observed among exposed FDNY firefighters.

描述（由申请人提供）：纽约市消防局（FDNY）第一反应人员和其他人员已广泛记录了在世界贸易中心（WTC）灾难现场工作对呼吸系统的短期和中期不良影响。我们的FDNY团队首次报告了WTC咳嗽综合征，证明了与灾难现场工作相关的暴露增加了9/11后9年的呼吸消化系统症状的几率，并表明医生诊断的呼吸系统疾病的患病率，无论是自我报告还是FDNY医生诊断，在现场工作7到9年后仍然升高。然而，与数百篇关于WTC相关下呼吸道疾病的出版物相比，我们发现只有5篇同行评议的出版物关注上呼吸道障碍，特别是慢性鼻窦炎（CRS）。在目前与美国国家职业安全与健康研究所的合作协议中，我们一直在使用创新的统计方法-参数生存模型与变化点-来检查WTC暴露和新发阻塞性气道疾病之间的关系是否在9/11后的第一个十年中保持稳定，或者观察到的相关性是否随着时间的推移而减弱。我们的初步结果证实了至少在暴露后的前五年内，疾病累积发病率的暴露反应/梯度的持续性。我们现在建议扩展这种方法来解决CRS发病率中的类似问题，CRS是与暴露于WTC救援/恢复工作相关的另一种常见呼吸系统疾病，其目标是确定暴露于FDNY消防员中观察到暴露反应梯度的时间长度。

项目成果

Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity.

暴露于世贸中心暴行后患者上、下呼吸道损伤内在风险的生物标志物。

• DOI: 10.1002/ajim.22643
• 发表时间: 2016
• 期刊: American journal of industrial medicine
• 影响因子: 3.5
• 作者: Zeig-Owens,Rachel;Nolan,Anna;Putman,Barbara;Singh,Ankura;Prezant,DavidJ;Weiden,MichaelD
• 通讯作者: Weiden,MichaelD

The effect of World Trade Center exposure on the latency of chronic rhinosinusitis diagnoses in New York City firefighters: 2001-2011.

世贸中心暴露对纽约市消防员慢性鼻窦炎诊断潜伏期的影响：2001-2011 年。

• DOI: 10.1136/oemed-2015-103094
• 发表时间: 2016
• 期刊: Occupational and environmental medicine
• 影响因子: 4.9
• 作者: Weakley,Jessica;Hall,CharlesB;Liu,Xiaoxue;Zeig-Owens,Rachel;Webber,MayrisP;Schwartz,Theresa;Prezant,David
• 通讯作者: Prezant,David