Improved treatment of congenital cytomegalovirus disease through study of placental models of pathogenesis

通过研究胎盘发病机制模型改进先天性巨细胞病毒病的治疗

• 批准号: nhmrc : 1045989
• 负责人: Dr Gillian Scott
• 金额: $ 45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improved-treatment-congenital-models-pathogenesis/111805
• 关键词: Improved; treatment; congenital; cytomegalovirus; disease

Congenital CMV is the second most common cause of fetal malformation in Australia, and yet most pregnant mothers do not know about it, nor how to prevent congenital CMV in their baby. It is a viral infection that can severely damage the unborn baby. Our research aims to find more about how the virus damages the baby, and whether antiviral drugs are useful in reducing infection of the baby, and also reducing damage to the baby from such infection. If successful, these studies will be the basis for clinical trials in pregnant women.

先天性巨细胞病毒是澳大利亚胎儿畸形的第二大常见原因，但大多数孕妇不知道这一点，也不知道如何预防婴儿的先天性巨细胞病毒。这是一种病毒感染，可以严重损害未出生的婴儿。我们的研究旨在更多地了解病毒如何损害婴儿，以及抗病毒药物是否有助于减少婴儿的感染，并减少这种感染对婴儿的损害。如果成功，这些研究将成为孕妇临床试验的基础。