Infections in Pregnancy: PathogenicMechanisms, Experimental Advances and Clinical Strategies

摘要 要求支持一次题为“妊娠感染：病原体”的Keystone专题讨论会 机制，实验进展和临床策略，由Helen Lazear，Carolyn Coyne博士组织 和大卫·阿罗诺夫。会议将于2023年1月22日至25日在新墨西哥州圣达菲举行。 胎盘通常为胎儿隔室提供了一个坚固的屏障， 能够穿透，并与母胎界面的其他防御一起发挥作用， 对抗先天性感染尽管如此，先天性病原体，包括人类巨细胞病毒，寨卡病毒， 弓形虫和B组链球菌可导致胎儿丢失、生长受限、出生缺陷， 发育迟缓先天性病原体的名单继续增长;例如，最近出现的 病毒SARS-CoV-2，可以导致破坏性的不良妊娠结局独立于垂直传播。 除了对胎儿和新生儿的致病作用外，妊娠期间的感染可具有明显的 由于怀孕的生理和免疫影响，对产妇健康的影响。因此， 需要更好地了解先天性感染和免疫防御的致病机制， 母胎界面，以及开发改进的疫苗，治疗和诊断策略， 对抗先天性感染。但在许多情况下，这些感染可能很难研究，由于限制， 实验系统和设计人类患者研究的挑战。Keystone研讨会 会议将汇集研究人员从一系列角度调查怀孕期间的感染 包括基础生物学、发病机理模型、临床研究和病人护理。该计划旨在 突出了在了解先天性感染的致病机制方面的新进展。其他 此外，会议还将分享研究先天性感染的实验系统的最新进展， 提供有关疫苗、治疗和诊断的最新进展的详细信息。该计划将 还应考虑到怀孕期间感染对孕产妇健康以及对胎儿的影响， 婴儿和儿童健康。这次会议将为来自不同背景的研究人员提供一个机会 交流思想和发展新的合作，以促进未来对怀孕期间感染的研究。 最后，本次会议将与另一个关于母胎串扰的Keystone研讨会会议配对。 这将使与会者在两个会议的机会，网络和发展新的合作，通过 分享会议和用餐。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies, organized by Drs. Helen Lazear, Carolyn Coyne and David Aronoff. The conference will be held in Santa Fe, New Mexico from January 22-25, 2023. The placenta generally provides a robust barrier to the fetal compartment across which relatively few microbes are able to penetrate, and functions together with other defenses at the maternal-fetal interface to protect against congenital infections. Nonetheless, congenital pathogens including human cytomegalovirus, Zika virus, Toxoplasma gondii, and group B streptococcus can cause fetal loss, growth restriction, birth defects, and developmental delays. The list of congenital pathogens continues to grow; for example, the recently emergent virus SARS-CoV-2, can cause devastating adverse pregnancy outcomes independent of vertical transmission. In addition to pathogenic effects on the fetus and neonate, infections during pregnancy can have distinct impacts on maternal health, owing to the physiologic and immunologic effects of pregnancy. As such, there is a need to better understand the pathogenic mechanisms of congenital infections and immune defenses at the maternal-fetal interface, as well as to develop improved vaccine, treatment, and diagnostic strategies to combat congenital infections. But in many cases these infections can be difficult to study due to limitations in experimental systems and challenges in designing studies with human patients. This Keystone Symposia conference will bring together researchers investigating infections in pregnancy from a range of perspectives including basic biology, pathogenesis models, clinical studies, and patient care. The program is designed to highlight the new advances in understanding the pathogenic mechanisms of congenital infections. Other sessions will share recent developments in experimental systems for studying congenital infections, in addition to providing details on the latest developments in vaccines, therapeutics, and diagnostics. The program will also be designed to consider the effects of infections during pregnancy on maternal health, as well as on fetal, infant, and child health. This conference will provide an opportunity for researchers from diverse backgrounds to exchange ideas and develop new collaborations to promote future research on infections during pregnancy. Finally, this conference is being paired with another Keystone Symposia meeting on Maternal-Fetal Crosstalk. This will allow participants at both conference the chance to network and develop new collaborations through shared sessions and meals.