CHROMATIN STRUCTURE AND DNA REPAIR

描述（申请人提供）：染色质结构和DNA修复在基因组稳定性中起着至关重要的作用，这对于正常的细胞功能至关重要。因此，DNA修复机制在基因组不稳定性研究中具有突出的特点。基因组不稳定性也与疾病发病机制有关，例如癌症的发展和衰老。通过基因组不稳定性与癌症进化机制相关的基本过程包括染色质的作用。这些专业过程的最新发现不仅为诊断和预后策略提供了概念框架，而且为新的DNA修复和染色质修饰驱动的治疗提供了概念框架。创新的、有创意的和经过科学检验的想法的集合，以及它们在亲密会议环境中的传播，有望在领先的领域研究人员之间促进有意义的交流，目的是揭示基于机制的抗癌策略，并确定现实的未来方向。此外，预计互动将为最近遭受一些不幸挫折的当地科研企业提供急需的推动力。这次研讨会的一个更重要的目的是激发和培养年轻学生和博士后的创造性思维，他们将肩负着维持和推进癌症研究领域的责任。这些专题讨论会的目标是汇集来自美利坚合众国各机构的成熟和发展中的科学家以及国际调查人员，通过在圣路易斯举行的为期两天的会议上的多个会议上介绍他们的科学发现，参与高度互动的科学论述。会议的主要目的是传播与该主题相关的基础、临床和转化研究的现状，并促进参与者之间的关键合作。会议的主题是染色质结构和DNA修复，将涵盖以下领域的最新领域：(1)染色质结构和DNA损伤传感，(2)染色质结构和DNA修复机制，(3)染色质结构和基因组稳定性。研讨会的成立是为了纪念已故的L. Tolmach博士对癌症生物学领域的开创性贡献。

DESCRIPTION (provided by applicant): Chromatin structure and DNA repair play a critical role in genomic stability, which is essential for normal cellular function. Mechanisms of DNA repair therefore are prominently featured in the studies of genomic instability. Genomic instability is also related to disease pathogenesis, e.g., cancer development and ageing. Fundamental processes mechanistically linked to the evolution of cancer through genomic instability include the role of chromatin. The latest discoveries in these specialized processes provide conceptual framework for not only diagnostic and prognostic strategies but novel DNA repair and chromatin modifying driven therapeutics. A congregation of innovative, creative and scientifically tested ideas and their dissemination in an intimate meeting setting is expected to foster meaningful cross-talk amongst leading area researchers for the purpose of unraveling mechanism-based strategies for combating cancer and establishing realistic future directions. In addition, interactions are expected to provide a much-needed impetus to the local scientific research enterprise that has suffered some unfortunate set backs in the recent past. A more important purpose served by this Symposium will be inspiring and cultivating creative thoughts in fertile minds of young students and post-doctoral fellows upon whom will lie the responsibility for sustaining and advancing the field of cancer research. The goal of these Symposia is to bring together established and developing scientists from various institutions within United States of America as well as international investigators to participate in highly interactive scientific discourses through the presentation of their scientific findings in multiple sessions over a two-day meeting in St Louis. The primary purpose of the meeting is to disseminate the current state of knowledge in basic, clinical and translational research related to the topic and foster critical collaborations between the participants. The theme of the meeting will be Chromatin Structure and DNA Repair which will cover the latest areas in the fields of (1) Chromatin structure and DNA damage sensing, (2) Chromatin structure and DNA Repair Mechanisms and (3) Chromatin structure and Genome Stability. The symposium was established to commemorate the seminal contributions of late Dr. L. Tolmach to the field of Cancer Biology.