Los Angeles Basin Clinical and Translational Science Institute

这次修订后的临床和转化科学奖(CTSA)申请将支持洛杉矶盆地临床和转化科学研究所(CTSI)的持续发展。我们的愿景是改善洛杉矶市区多样化和服务不足的人口的健康。通过这样做，获得我们可以与他人分享的知识，以改善全球城市环境和特大城市的健康。为了追求这一愿景，我们在洛杉矶市中心与领先的学术、临床和社区卫生组织建立了独特的合作伙伴关系。我们正在将这种合作伙伴关系转变为一家卓越的临床和转化科学研究所，专注于为多样化的城市社区提供更好的健康。我们为CTSI确立了四个主要目标：在许多独立优势的基础上，创建一个高度重视临床和翻译科学的综合学术之家；创建新的翻译研究团队，并开展利用我们独特的人口和伙伴关系的项目，以解决我们当地最好的科学机会和最重要的健康优先事项 这项工作将有助于提高社区的健康水平；改革教育和培训，培养一支以临床和转化性研究为主要职业的队伍；通过区域和国家网络与合作，实施和传播我们学到的改善当地社区健康和推进转化性研究的知识。为了实现这些目标，我们组建了一支卓越的领导团队，通过CTSI正在创建：用于积极开发新研究项目和团队的出色资源；用于促进和支持基础、临床和社区研究的强大基础设施；用于数据获取、集成、管理和分析的尖端方法；利用远程教育对基础、临床和社区研究人员进行综合培训，并侧重于针对不同社区的研究；利用专业传播专业知识传播我们的研究成果的新颖方法；以及一个跟踪和评估我们的进展和影响的专业评估小组。利用330万美元的机构支持，我们已经在将当地环境转变为高度重视临床和转化性研究的家庭方面取得了重大进展。我们表现出强大的能力来产生和支持令人兴奋的新研究，从替补席到我们的社区。通过CTSA和承诺在五年内提供1870万美元的机构支持，我们将扩展为一个功能齐全的研究所，将对改善城市健康和推进临床和转化研究学科产生重大影响。

This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision Is to improve health of the diverse and underserved population of urban Los Angeles and. In doing so, to gain knowledge that we can share with others to Improve health In urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science; create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities; transform education and training to create a cadre of people with a major career focus on clinical and translational research; and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis; integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities; a novel approach to dissemination of our findings using professional communications expertise; and a professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.