Message Framing and HPV Vaccination Acceptance among African Americans

描述（由申请人提供）：在美国，宫颈癌的发病率和死亡率存在显着的种族差异，尽管总体人口的发病率和死亡率总体下降。特别是，非洲裔美国女性比非西班牙裔白人女性患宫颈癌和死亡的可能性明显更高。然而，非裔美国人也是对建议年轻女性预防宫颈癌的新型人乳头瘤病毒 (HPV) 疫苗持最不赞成态度的群体之一。非常需要针对符合疫苗资格的年轻非洲裔美国女性的照顾者，制定有关 HPV 疫苗接种的有效沟通干预措施。先前的研究表明，根据执行推荐行为可能获得的好处与不遵循建议可能产生的成本来构建健康信息，可能会系统地影响信息的有效性。尽管对信息框架进行了广泛的研究，但人们对信息框架对符合疫苗资格的年轻非裔美国女性的看护者 HPV 疫苗接种接受度的影响以及这些影响在多大程度上可能受到看护者与疫苗相关的信念（例如感知的疫苗安全性和有效性）的调节程度知之甚少。为了增进关于如何使用信息框架来促进非裔美国人社区接受 HPV 疫苗接种的科学知识，我们将开展一项以社区为基础的随机试验，对 150 名符合疫苗资格的 9-17 岁年轻非裔美国女性的看护者进行一项以评估增益与损失框架信息的相对功效。拟议的项目将为有针对性的信息设计提供有用的见解，以提高符合疫苗资格的年轻非洲裔美国女性的照顾者对 HPV 疫苗接种的接受度。这项研究还将为一项研究计划奠定基础，该计划旨在开发基于理论的沟通干预措施，以促进非裔美国人社区的 HPV 疫苗接种，最终目标是减少和消除宫颈癌发病率和死亡率的种族差异。 公共卫生相关性：拟议研究的主要目的是测试两种沟通策略在促进符合疫苗资格的年轻非洲裔美国女性的看护者接受 HPV 疫苗接种方面的相对功效。如果成功，该项目将有助于了解促进 HPV 疫苗接种的信息框架效应，并为有针对性的信息设计提供有用的见解，以提高符合疫苗资格的年轻非洲裔美国女性的照顾者对 HPV 疫苗接种的接受度。

DESCRIPTION (provided by applicant): Significant racial disparities exist in the incidence and mortality rates of cervical cancer in the US, despite an overall decline in these rates for the population as a whole. In particular, African American women are significantly more likely to get and die from cervical cancer than non-Hispanic White women. African Americans, however, are also among the group that holds the least favorable attitudes toward the new human papillomavirus (HPV) vaccine recommended for young women to prevent cervical cancer. There is a tremendous need for developing effective communication interventions about HPV vaccination targeting caretakers of vaccine-eligible young African American women. Previous research indicates that framing a health message in terms of the benefits that may be achieved by performing the recommended behavior versus the costs that may be incurred by not following the recommendation could systematically influence message efficacy. Despite extensive research on message framing, little is known about the effects of message framing on HPV vaccination acceptance among caretakers of vaccine-eligible young African American women and the extent to which these effects may be moderated by the caretakers' vaccine-related beliefs such as perceived vaccine safety and efficacy. To advance scientific knowledge on how message framing can be used to foster HPV vaccination acceptance in African American communities, we will conduct a community-based randomized trial with 150 caretakers of vaccine-eligible young African American women ages 9-17 to assess the relative efficacy of gain- vs. loss-framed messages. The proposed project will provide useful insights into the design of targeted messages to improve HPV vaccination acceptance among caretakers of vaccine-eligible young African American women. This study will also set the stage for a program of research aimed at developing theory-based communication interventions for promoting HPV vaccination in African American communities, with the ultimate goal of reducing and eliminating racial disparities in cervical cancer incidence and mortality rates. PUBLIC HEALTH RELEVANCE: The primary objective of the proposed study is to test the relative efficacy of two communication strategies in promoting HPV vaccination acceptance among caretakers of vaccine-eligible young African American women. If successful, this project will help understand message framing effects in the promotion of HPV vaccination and provide useful insights into the design of targeted messages to improve HPV vaccination acceptance among caretakers of vaccine-eligible young African American women.