Omega-3 Fatty Acids, Cardiovascular Risk and Behavior

Omega-3 脂肪酸、心血管风险和行为

基本信息

批准号：
8216010
负责人：
MATTHEW F MULDOON
金额：
$ 33.61万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-02-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8216010
关键词：
Adult Affect Affective Age-Years Aggressive behavior American American Heart Association Amygdaloid structure Anger Arachidonate 5-Lipoxygenase Atherosclerosis Attention Deficit Disorder Behavior Behavior assessment Behavioral Biological Availability Biological Markers Brain imaging Cardiovascular Diseases Carotid Arteries Cause of Death Cell physiology Chronic Coenzyme A Communities Consumption Detection Diet Eating Epidemiology Event Fatty Acids Fish Oils Fishes Forensic Medicine Genes Genetic Polymorphism Genetic Variation Goals Heart Diseases Heart Rate Homeostasis Hostility Impulsivity Individual Differences Inflammation Intake Interleukin-6 Intervention Interview Investigation Laboratories Ligase Link Lipoxygenase Literature Major Depressive Disorder Measures Medial Mental Depression Mental Health Methods Micronutrients Moods Neurophysiology - biologic function Observational Study Omega-3 Fatty Acids Participant Patients Personal Satisfaction Persons Phenotype Phospholipids Placebo Control Primary Prevention Production Program Research Project Grants Proteins Psychometrics Relative (related person)Reporting Research Rest Rewards Risk Behaviors Risk Factors Role Sampling Serum Stimulus Structure Supplementation Testing Thick Ultrasonography Variant Vascular Diseases Ventral Striatum base biobehavior cardiovascular disorder risk cardiovascular risk factor cyclooxygenase 2 cytokine depressive symptoms disability emotion regulation fatty acid metabolism heart disease risk heart rate variability heart rhythm inflammatory marker instrument mortality neuronal cell body pre-clinical promoter psychologic psychosocial relating to nervous system research study standard measure volunteer

项目摘要

Long-chain omega-3 fatty acids are available primarily via consumption of fish and are known to serve many important roles in cell function and body homeostasis. Furthermore, these micronutrients reduce cardiovascular disease (CVD) events when supplemented in the diets of patients with pre-existing heart disease. Given that Americans currently consume an average of only 120 mg of long-chain omega-3 fatty acids each day,the American Heart Association now recommends now recommends that all adults eat fish, particularly fatty fish, as least twice a week. As yet there is little direct evidence to support such an advisory since it is not clear either whether or how increasing fish consumption in the diet of the general pubic will reduce the risk of heart disease. In separate research, a relative deficiency in the omega-3 fatty acids has been associated with major depression, attention-deficit disorder and aggressive behavior in forensic samples. Once again, studies in healthy adults are lacking. Project 3 of this Program Project Grant application proposes to conduct two investigations, an observational study of 530 generally-healthy community volunteers 30-55 year of age,and,in a subset reporting low consumption of omega-3 fatty acids, a placebo-controlled supplementation experiment of 4 months duration. In both studies, markers of cardiovascular risk will be measured, as will psychological and behavioral characterises that have previously been linked to heart disease and omega-3 fatty acid availability. In addition, the observational study will include carotid ultrasound as a measure of pre-clinical atherosclerosis and functional brain imaging of regions regulating affect/threat detection and impulsivity/goal-directed behaviors. The research will test the hypotheses that high or raised EPA and DMA intake: 1) reduces CVD risk, 2) reduces depressive symptoms and antagonistic disposition, 3) reduces impulsivity and aggression, and 4) is related to activation of neural structures involved in affect and goal- directed behaviors. Finally, the effects of variation in genes regulating fatty acid metabolism will be studied.

长链omega-3脂肪酸主要是通过食用鱼类的，已知可以为许多在细胞功能和身体稳态中的重要作用。此外，这些微量营养素还原心血管疾病（CVD）事件在饮食中补充饮食疾病。鉴于美国人目前平均消耗120毫克的长链omega-3脂肪酸每天，美国心脏协会现在建议现在建议所有成年人吃鱼，特别是脂肪鱼，至少每周两次。到目前为止，几乎没有直接证据支持这种咨询由于尚不清楚一般耻骨饮食中的鱼类消耗是否会增加降低心脏病的风险。在单独的研究中，omega-3脂肪酸的相对缺乏具有与大抑郁症，注意力缺陷障碍和法医样本中的侵略性行为有关。再次缺乏对健康成年人的研究。该计划项目3的项目赠款申请提出了为了进行两项调查，一项对530个健康社区志愿者的观察性研究30-55 年龄，并且在报告欧米茄3脂肪酸消耗的子集中，安慰剂对照持续4个月的补充实验。在这两项研究中，心血管风险的标记将是经过测量，心理和行为的特征也将与心脏病联系在一起和omega-3脂肪酸的可用性。此外，观察性研究将包括颈动脉超声临床前动脉粥样硬化和调节影响/威胁检测的区域功能性脑成像的度量和冲动/目标指导的行为。该研究将检验高EPA或提高EPA的假设以及 DMA摄入量：1）降低CVD风险，2）减少抑郁症状和拮抗性，3）减少冲动性和侵略性，以及4）与激活情感和目标有关的神经结构的激活定向行为。最后，将研究调节脂肪酸代谢的基因变异的影响。