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Studying Colorectal Cancer Effectiveness of Screening Strategies (SuCCESS)

研究结直肠癌筛查策略的有效性 (SuCCESS)

基本信息

批准号：
8335410
负责人：
CAROLYN M RUTTER
金额：
$ 84.63万
依托单位：
KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8335410
关键词：
Address Advisory Committees Behavior Benefits and Risks Cancer Etiology Cessation of life Colorectal Colorectal Cancer Commit Complex Data Data Collection Data Sources Diagnostic Procedure Disease Documentation Effectiveness Equilibrium Evaluation Foundations Goals Health Health Personnel Individual Information Systems Instruction Integrated Delivery of Health Care Knowledge Link Medical Meta-Analysis Methods Modality Modeling Morbidity - disease rate Outcome Pathologic Pathology Patient Preferences Patients Pattern Policies Policy Maker Preventive Process Provider Public Health Recommendation Recording of previous events Regimen Relative (related person)Research Research Activity Research Institute Research Personnel Risk Risk Factors Screening for cancer Screening procedure Second Primary Cancers Services Source Staging Subgroup System Testing United States Washington Work adenoma base cancer diagnosis cancer therapy clinical practice cohort colorectal cancer screening comparative effectiveness compare effectiveness cost electronic data evidence base improved information gathering member models and simulation mortality multidisciplinary prevent prospective

项目摘要

PROJECT SUMIVIARY (See Instructions): The overarching goal of our proposed project, SuCCESS: Studying Colorectal Cancer: Effectiveness of Screening Strategies, is to develop evidence to inform personalized screening recommendations that maintain most or all of the benefits of intensive screening, minimize risks and costs, and respect patient preferences. Based within Group Health Research Institute (GHRI), the SuCCESS project will draw on a wide array of rich electronic data sources available at Group Health (GH), an integrated health care delivery system in Washington State, to gather information about risk factors, screening patterns, diagnostic procedures, pathology, treatment, and cancer outcomes among GH enrollees. The SuCCESS project will use GH data to describe colorectal cancer (CRC) screening as practiced, including behaviors and effectiveness, and will build on this information to examine the potential for personalized screening regimens. We propose 3 linked projects related to this overall goal. Project 1, "Comparative effectiveness of colorectal cancer screening as practiced," will provide information about how screening is practiced, about patient decisions regarding screening modalities, and about the comparative effectiveness of different screening regimens as practiced. Project 2: "Personalizing colorectal cancer screening and surveillance," will focus on identifying effective personalized screening regimens based on screening history and other individual risk factors. Project 3, "Modeling long-term comparative effectiveness of colorectal screening," will use disease simulation models to predict the long-term effectiveness of different screening and surveillance regimens on botii overall and CRC mortality based on results from Project 1 and Project 2, and will develop a cohort model for CRC that will be freely distributed. Our proposed body of research will provide an important foundation for personalized clorectal cancer screening, and will produce results that are useful to a multidisciplinary audience, including clinicians, patients, policy makers, researchers, and professional medical organizations.

项目概要（见说明）：