Studying Colorectal Cancer Effectiveness of Screening Strategies (SuCCESS)

研究结直肠癌筛查策略的有效性 (SuCCESS)

• 批准号: 8221760
• 负责人: CAROLYN M RUTTER
• 金额: $ 124.35万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8221760
• 关键词: Address; Advisory Committees; Behavior; Benefits and Risks; Cancer Etiology; Cessation of life; Colorectal; Colorectal Cancer; Commit; Complex; Data; Data Collection; Data Sources; Diagnostic Procedure; Disease; Documentation; Effectiveness; Equilibrium; Evaluation; Foundations; Goals; Health; Health Personnel; Individual; Information Systems; Instruction; Integrated Delivery of Health Care; Knowledge; Link; Medical; Meta-Analysis; Methods; Modality; Modeling; Morbidity - disease rate; Outcome; Pathologic; Pathology; Patient Preferences; Patients; Pattern; Policies; Policy Maker; Preventive; Process; Provider; Public Health; Recommendation; Recording of previous events; Regimen; Relative (related person); Research; Research Activity; Research Institute; Research Personnel; Risk; Risk Factors; Screening for cancer; Screening procedure; Second Primary Cancers; Services; Source; Staging; Subgroup; System; Testing; United States; Washington; Work; adenoma; base; cancer diagnosis; cancer therapy; clinical practice; cohort; colorectal cancer screening; comparative effectiveness; compare effectiveness; cost; electronic data; evidence base; improved; information gathering; member; models and simulation; mortality; multidisciplinary; prevent; prospective

PROJECT SUMIVIARY (See Instructions): The overarching goal of our proposed project, SuCCESS: Studying Colorectal Cancer: Effectiveness of Screening Strategies, is to develop evidence to inform personalized screening recommendations that maintain most or all of the benefits of intensive screening, minimize risks and costs, and respect patient preferences. Based within Group Health Research Institute (GHRI), the SuCCESS project will draw on a wide array of rich electronic data sources available at Group Health (GH), an integrated health care delivery system in Washington State, to gather information about risk factors, screening patterns, diagnostic procedures, pathology, treatment, and cancer outcomes among GH enrollees. The SuCCESS project will use GH data to describe colorectal cancer (CRC) screening as practiced, including behaviors and effectiveness, and will build on this information to examine the potential for personalized screening regimens. We propose 3 linked projects related to this overall goal. Project 1, "Comparative effectiveness of colorectal cancer screening as practiced," will provide information about how screening is practiced, about patient decisions regarding screening modalities, and about the comparative effectiveness of different screening regimens as practiced. Project 2: "Personalizing colorectal cancer screening and surveillance," will focus on identifying effective personalized screening regimens based on screening history and other individual risk factors. Project 3, "Modeling long-term comparative effectiveness of colorectal screening," will use disease simulation models to predict the long-term effectiveness of different screening and surveillance regimens on botii overall and CRC mortality based on results from Project 1 and Project 2, and will develop a cohort model for CRC that will be freely distributed. Our proposed body of research will provide an important foundation for personalized clorectal cancer screening, and will produce results that are useful to a multidisciplinary audience, including clinicians, patients, policy makers, researchers, and professional medical organizations.

项目摘要（参见说明）： 我们提出的项目 SuCCESS：研究结直肠癌：筛查策略的有效性的总体目标是开发证据，为个性化筛查建议提供信息，以保持强化筛查的大部分或全部益处，最大限度地降低风险和成本，并尊重患者的偏好。 SuCCESS 项目以团体健康研究所 (GHRI) 为基础，将利用 Group Health (GH) 是华盛顿州的一个综合医疗保健提供系统，提供各种丰富的电子数据源，用于收集有关 GH 参与者的风险因素、筛查模式、诊断程序、病理学、治疗和癌症结果的信息。 SuCCESS 项目将使用 GH 数据来描述实践中的结直肠癌 (CRC) 筛查，包括行为和有效性，并将在此信息的基础上研究个性化筛查方案的潜力。 我们提出了与这一总体目标相关的 3 个相关项目。项目 1“结直肠癌筛查实践的比较有效性”将提供有关如何实施筛查、患者关于筛查方式的决定以及不同筛查的比较有效性的信息 实践中的治疗方案。项目 2：“个性化结直肠癌筛查和监测”将侧重于根据筛查历史和其他个人风险因素确定有效的个性化筛查方案。项目 3“结直肠筛查的长期比较有效性建模”将根据项目 1 和项目 2 的结果，使用疾病模拟模型来预测不同筛查和监测方案对 botii 总体和 CRC 死亡率的长期有效性，并将开发一个免费分发的 CRC 队列模型。我们提出的研究主体将为个性化结直肠癌筛查提供重要基础，并将产生对多学科受众有用的结果，包括临床医生、患者、政策制定者、研究人员和专业医疗组织。